Merck Manual

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Richard J. Schwab

, MD, University of Pennsylvania, Division of Sleep Medicine

Reviewed/Revised May 2022 | Modified Sep 2022
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Narcolepsy is a sleep disorder marked by excessive sleepiness during the day or recurring, uncontrollable episodes of sleep during normal waking hours, usually with sudden, temporary episodes of muscle weakness (cataplexy). Other symptoms include sleep paralysis, vivid dreams, and hallucinations while falling asleep or waking up from sleep.

  • Testing in a sleep laboratory, with polysomnography and multiple sleep latency testing, is needed to confirm the diagnosis.

  • Drugs may be used to help keep people awake and to control other symptoms.

Narcolepsy occurs in about 1 of 2,000 people in the United States, Europe, and Japan. It is equally common among men and women.

What causes narcolepsy is unknown. Some people with narcolepsy have a similar group of genes, but the cause is not thought to be genetic. Environmental factors seem to be involved and may trigger the disorder. Some evidence suggests that narcolepsy may be caused by an autoimmune reaction that destroys nerve cells in a certain area of the brain. (An autoimmune reaction Autoimmune Disorders occurs when the immune system attacks the body's own tissues.)

People with narcolepsy sleep a lot during the day. As a result, narcolepsy can be disabling and increases the risk of motor vehicle and other accidents. Narcolepsy persists throughout life but does not affect life expectancy.

Narcolepsy reflects, in part, abnormalities in the timing and control of rapid eye movement (REM) sleep. Many symptoms resemble what happens during REM sleep. The muscle weakness, sleep paralysis, and hallucinations of narcolepsy resemble the loss of muscle tone, paralysis, and vivid dreaming that occur during REM sleep.

Idiopathic hypersomnia, like narcolepsy, results in excessive daytime sleepiness. Typically, people with this disorder have trouble waking up, and when they wake up, they feel drowsy, mentally foggy, and as if they cannot move (called sleep inertia). Polysomnography Diagnosis and a multiple sleep latency test Diagnosis are needed to help determine whether narcolepsy or idiopathic hypersomnia is causing excessive daytime sleepiness.

Symptoms of Narcolepsy

Symptoms of narcolepsy usually begin during adolescence or young adulthood and persist throughout life.

The main symptoms are

  • Severe excessive daytime sleepiness

  • Cataplexy (sudden, temporary episodes of muscle weakness)

  • Hallucinations while falling asleep or waking up

  • Sleep paralysis

  • Disturbances in nighttime sleep (such as waking up frequently and having vivid, frightening dreams)

Only about 10% of people with narcolepsy have all the symptoms. Most people have only a few. All have excessive daytime sleepiness.

Excessive daytime sleepiness

People with narcolepsy have excessive daytime sleepiness, often despite long periods of excessive sleep. Many people are overcome by sudden episodes of uncontrollable sleep that can occur at any time, often without warning (called sleep attacks). Falling asleep can be resisted only temporarily.

People may have many episodes or only a few in a single day. Each usually lasts a few minutes or less but may last hours. People can be awakened as readily as from normal sleep. They typically feel refreshed when they wake up even when the sleep episode lasts a few minutes. However, they may fall asleep again in a few minutes.

Episodes of falling asleep are most likely to occur in monotonous situations, as during boring meetings or long periods of highway driving, but may occur while eating, speaking, or writing.


While people are awake during the day, a sudden, temporary episode of muscle weakness without loss of consciousness—called cataplexy—may be triggered by a sudden emotional reaction such as anger, fear, joy, laughter, or surprise. People may become limp, drop something being held, or fall to the ground. The jaw may droop, facial muscles may twitch, eyes may close, and the head may nod. Vision may be blurred. People may slur their speech.

These episodes resemble the normal muscle paralysis that occurs during rapid eye movement (REM) sleep and, to a lesser degree, the experience of being “weak with laughter.”

Cataplexy causes significant problems in about one fifth of people with narcolepsy.

Sleep paralysis

Occasionally, when just falling asleep or immediately after awakening, people try to move but cannot. This experience, called sleep paralysis, can be terrifying. The touch of another person may relieve the paralysis. Otherwise, the paralysis disappears on its own after several minutes.

Sleep paralysis occurs in about one fourth of people with narcolepsy. It sometimes occurs in healthy children and, less often, in healthy adults.


When just falling asleep or, less often, when awakening, people may clearly see images or hear sounds that are not there. These extremely vivid hallucinations are similar to those of normal dreaming but are more intense. Hallucinations are called

  • Hypnagogic when they occur while falling asleep

  • Hypnopompic when they occur while awakening

Hypnagogic hallucinations occur in about one third of people with narcolepsy. They are common among healthy children and occasionally occur in healthy adults.

Disturbances in nighttime sleep

In people with narcolepsy, nighttime sleep may be interrupted periodically by awakenings and vivid, frightening dreams. As a result, sleep is unrefreshing, and people may be even sleepier during the day.


People with narcolepsy often have difficulty functioning and concentrating. They are more likely to injure themselves—for example, if they fall asleep while driving. Narcolepsy can cause stress. Productivity and motivation may decrease, and concentration may be poor. People may withdraw from others and thus damage personal relationships. Many become depressed.

Diagnosis of Narcolepsy

  • Polysomnography

  • Multiple sleep latency testing

Doctors suspect narcolepsy when people with excessive daytime sleepiness have had episodes of muscle weakness. However, doctors cannot base the diagnosis on symptoms alone because other disorders can cause some of the same symptoms. Sleep paralysis and similar hallucinations occasionally occur in otherwise healthy adults, in people who have been sleep deprived, and in people with sleep apnea or depression. These symptoms may also occur when certain drugs are taken. Therefore, testing in a sleep laboratory is necessary.

Sleep testing in a sleep laboratory consists of

  • Polysomnography, done overnight

  • Multiple sleep latency testing, done the next day

Polysomnography is usually done in a sleep laboratory, which may be located in a hospital, clinic, hotel room, or other facility that is equipped with a bed, bathroom, and monitoring equipment. Electrodes are pasted to the scalp and face to record the brain's electrical activity (electroencephalography Electroencephalography Diagnostic procedures may be needed to confirm a diagnosis suggested by the medical history and neurologic examination. Imaging tests commonly used to diagnose nervous system (neurologic) disorders... read more Electroencephalography , or EEG) as well as eye movements. Applying these electrodes is painless. The recordings help provide doctors with information about sleep stages. Electrodes are also attached to other areas of the body to record heart rate (electrocardiography Electrocardiography Electrocardiography (ECG) is a quick, simple, painless medical test that measures the heart’s electrical impulses. During an ECG, the heart's electrical impulses are measured, amplified, and... read more Electrocardiography , or ECG), muscle activity (electromyography Electromyography and Nerve Conduction Studies Diagnostic procedures may be needed to confirm a diagnosis suggested by the medical history and neurologic examination. Imaging tests commonly used to diagnose nervous system (neurologic) disorders... read more Electromyography and Nerve Conduction Studies ), and breathing. A painless clip is attached to a finger or an ear to record oxygen levels in the blood. Polysomnography can detect breathing disorders (such as obstructive sleep apnea), seizure disorders, narcolepsy, periodic limb movement disorder, and unusual movements and behaviors during sleep (parasomnias).

A multiple sleep latency test is done to distinguish between physical fatigue and excessive daytime sleepiness and to check for narcolepsy. People spend the day in a sleep laboratory. They are given the opportunity to take five naps at 2-hour intervals. They lie in a darkened room and are asked to take a nap. Polysomnography is used as part of this test to assess how quickly people fall asleep. It detects when people fall asleep and is used to monitor the stages of sleep during the naps and to determine whether REM (dreaming) sleep occurs. During multiple sleep latency testing, people with narcolepsy typically fall asleep quickly and have at least two REM naps.

These tests involve monitoring and recording the activity of the brain, heart, breathing, muscles, and eyes. Various other body functions, including movement of the limbs, are also monitored and recorded.

Usually, narcolepsy does not result from abnormalities that can be detected by brain imaging procedures, such as computed tomography (CT) or magnetic resonance imaging (MRI). However, doctors may use brain imaging and blood and urine tests to rule out other disorders that can cause excessive daytime sleepiness.

Treatment of Narcolepsy

  • General measures

  • Drugs that help keep people awake

There is no cure for narcolepsy. However, for many people, continued treatment results in normal lives.

People should also try to get enough sleep at night and take brief naps (less than 30 minutes) at the same time every day (typically afternoon). If symptoms are mild, these measures may be all that is needed. People with cataplexy should try to avoid anything that triggers cataplexy, such as laughter, anger, and fear.

For others, drugs that help keep people awake, such as modafinil, armodafinil, solriamfetol, pitolisant, sodium oxybate, or a combination drug that contains calcium, magnesium, potassium, and sodium oxybates are used to help reduce the sleepiness. Doctors monitor people closely during drug treatment.

Modafinil, armodafinil, solriamfetol, and pitolisant keep people awake by interacting with different receptors in the brain. The drugs are taken once a day in the morning or can be taken by shift workers an hour before they begin work. These four drugs are the preferred treatment for people who have narcolepsy without cataplexy. Generally, all of these drugs are safe, but they may cause headache, nausea, vomiting, and a rash. Pregnant women should not take modafinil because it may cause severe birth defects, including heart defects.

Sodium oxybate and the combination oxybate drug can usually lessen excessive daytime sleepiness and cataplexy. These drugs are taken while in bed and again during the night. These drugs are the preferred treatment for people with narcolepsy and cataplexy. Side effects include nausea, vomiting, dizziness, urinary incontinence (involuntary urination), sleepiness, and sometimes sleepwalking.

Dextroamphetamine and methylphenidate, which are stimulants, are used only if other narcolepsy drugs are ineffective or cause intolerable problems. These stimulants can cause agitation, high blood pressure, a fast heart rate, and moodiness. They may also be habit-forming. Before doctors prescribe dextroamphetamine or methylphenidate for people who are over 40, an exercise stress test is done to check for heart disease.

Treatment of idiopathic hypersomnia Narcolepsy is similar to that of narcolepsy—with drugs that help keep people awake.

Drugs Mentioned In This Article

Generic Name Select Brand Names
Dexedrine, Dexedrine Spansule, DextroStat, Liquadd , ProCentra , XELSTRYM, Zenzedi
Adhansia XR, Aptensio XR, Concerta, Cotempla XR, Daytrana, Jornay, Metadate CD, Metadate ER, Methylin, QuilliChew ER, Quillivant XR, RELEXXII, Ritalin, Ritalin LA, Ritalin SR
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