(See also Overview of Drugs Overview of Drugs A drug is defined by U.S. law as any substance (other than a food or device) intended for use in the diagnosis, cure, relief, treatment, or prevention of disease or intended to affect the structure... read more .)
A placebo is made to look exactly like a real drug but is made of an inactive substance, such as a starch or sugar. Placebos are now used only in research studies (see The Science of Medicine The Science of Medicine Doctors have been treating people for many thousands of years. The earliest written description of medical treatment is from ancient Egypt and is over 3,500 years old. Even before that, healers... read more ).
Despite there being no active ingredients, some people who take a placebo feel better. Some others develop "side effects." This phenomenon, called the placebo effect, appears to occur for two reasons. The first reason is coincidental change. Many medical conditions and symptoms come and go without treatment, so a person taking a placebo may just coincidentally feel better or worse. When this change occurs, the placebo may incorrectly be credited with or blamed for the result. The second reason is anticipation (sometimes called suggestibility). Anticipating that a drug will work often actually makes people feel better.
The placebo effect is mainly on symptoms rather than the actual disease. For example, a placebo will never make a broken bone heal faster, but it may make the pain seem less. Some people seem more susceptible to the placebo effect than others. People who have a positive opinion of drugs, doctors, nurses, and hospitals are more likely to respond favorably to placebos than are people who have a negative opinion.
When a new drug is being developed, investigators conduct studies to compare the effect of the drug with that of a placebo because any drug can have a placebo effect, unrelated to its action. The true drug effect must be distinguished from a placebo effect. Typically, half the study's participants are given the drug, and half are given an identical-looking placebo. Ideally, neither the participants nor the investigators know who received the drug and who received the placebo (this type of study is called a double-blind study).
When the study is completed, all changes observed in participants taking the active drug are compared with those in participants taking the placebo. The drug must perform significantly better than the placebo to justify its use. In some studies, as many as 50% of participants taking the placebo improve (an example of the placebo effect), making it difficult to show the effectiveness of the drug being tested.
The following are some English-language resources that may be useful. Please note that THE MANUAL is not responsible for the content of these resources.
The Center for Information and Study on Clinical Research Participation (CISCRP): A nonprofit organization that educates and informs patients, medical researchers, the media, and policy makers about the roles they all play in clinical research
ClinicalTrials.gov: A database of privately and publicly funded clinical studies conducted around the world