Noncancerous thyroid enlargement can occur because of lack of iodine in the diet or ingestion of certain substances or medications.
People often have no symptoms.
Doctors do blood tests to determine how well the thyroid is working.
Doctors may treat the cause of the enlargement, and sometimes people need surgery to remove part of the enlarged thyroid.
(See also Overview of the Thyroid Gland Overview of the Thyroid Gland The thyroid is a small gland, measuring about 2 inches (5 centimeters) across, that lies just under the skin below the Adam’s apple in the neck. The two halves (lobes) of the gland are connected... read more .)
The word goiter is sometimes used to describe any form of thyroid gland enlargement (for example, enlargement caused by inflammation or cancer). Simple, nontoxic goiter is a specific form of noncancerous enlargement.
The most common cause of simple nontoxic goiter in most of the world is
The thyroid gland uses iodine to make thyroid hormone. When there is not enough iodine, the thyroid gland grows larger in an attempt to compensate. However, in the United States, most salt is fortified with iodine, so lack of iodine is not a common cause of goiter.
Other causes of simple nontoxic goiter include
Using certain medications (such as amiodarone or lithium)
Eating certain foods in unusually large amounts (such as cassava, broccoli, cauliflower, and cabbage)
Sometimes a goiter forms temporarily during puberty, pregnancy, or menopause.
In people with simple, nontoxic goiter, the thyroid gland produces normal amounts of thyroid hormones, so people do not have an underactive thyroid (hypothyroidism Hypothyroidism Hypothyroidism is underactivity of the thyroid gland that leads to inadequate production of thyroid hormones and a slowing of vital body functions. Facial expressions become dull, the voice... read more 
) or an overactive thyroid (hyperthyroidism Hyperthyroidism Hyperthyroidism is overactivity of the thyroid gland that leads to high levels of thyroid hormones and speeding up of vital body functions. Graves disease is the most common cause of hyperthyroidism... read more 
).
Symptoms of Simple Nontoxic Goiter
People typically notice a swelling at the base of the neck but have no other symptoms. Sometimes the goiter presses on nearby tissue and causes cough, hoarseness, or difficulty breathing or swallowing. In people with subacute thyroiditis Subacute Thyroiditis Subacute thyroiditis is acute inflammation of the thyroid, probably caused by a virus. (See also Overview of the Thyroid Gland.) Subacute thyroiditis usually begins suddenly. In this disorder... read more , the gland usually is painful and tender to the touch.
Diagnosis of Simple Nontoxic Goiter
Thyroid function tests
Ultrasonography and a thyroid scan
Doctors usually do blood tests to determine how the gland is functioning (thyroid function tests Thyroid function tests The thyroid is a small gland, measuring about 2 inches (5 centimeters) across, that lies just under the skin below the Adam’s apple in the neck. The two halves (lobes) of the gland are connected... read more ). They measure blood levels of the thyroid hormones thyroxine (T4, or tetraiodothyronine) and triiodothyronine (T3) and thyroid-stimulating hormone (TSH). Sometimes doctors also look for antibodies that attack the thyroid gland (antithyroid antibodies) in the blood, which are a sign of an immune reaction to the thyroid, which causes inflammation.
Doctors do a radioactive iodine uptake test and a thyroid scan Thyroid ultrasound The thyroid is a small gland, measuring about 2 inches (5 centimeters) across, that lies just under the skin below the Adam’s apple in the neck. The two halves (lobes) of the gland are connected... read more . For these tests, the person ingests (or is injected with) a small amount of radioactive iodine. The radioactive iodine concentrates in the thyroid gland. A scanner can detect how much iodine is taken up by the gland and a gamma camera (which detects radiation) produces a picture of the thyroid gland. These scans show any physical abnormalities in the gland that might suggest Graves disease Causes , thyroid nodules, or thyroiditis.
Doctors do ultrasonography, which uses sound waves to create an image of the thyroid gland, to identify any nodules that could be cancerous.
Treatment of Simple Nontoxic Goiter
Sometimes iodine supplements
Sometimes thyroid hormone replacement
Sometimes surgery
Treatment depends on the size and cause of goiter.
In iodine-deficient areas, people are given iodine supplements. Iodine may be added to salt, water, or crops to eliminate iodine deficiency in the area. People should stop eating foods that inhibit thyroid hormone production, for example, cassava, broccoli, cauliflower, and cabbage.
When diet is not a cause, some people may be given thyroid hormone replacement with levothyroxine. This medication blocks production of thyroid-stimulating hormone and may shrink the goiter.
People with very large goiters may need surgery to remove part of the thyroid or may be given radioactive iodine to shrink the gland enough to prevent interference with breathing or swallowing or to correct cosmetic problems.
Drugs Mentioned In This Article
| Generic Name | Select Brand Names |
|---|---|
amiodarone |
Cordarone, Nexterone, Pacerone |
lithium |
Eskalith, Eskalith CR, Lithobid |
levothyroxine |
Ermeza, Estre , Euthyrox, Levo-T, Levothroid, Levoxyl, Synthroid, Thyquidity, Thyro-Tabs, TIROSINT, TIROSINT-SOL, Unithroid |
