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Spleen Disorders and Immunodeficiency

By

James Fernandez

, MD, PhD, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University

Last full review/revision Apr 2021| Content last modified Apr 2021
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For people whose spleen is absent at birth or has been damaged or removed because of disease, the risk of developing severe bacterial infections is increased.

People who have a spleen disorder or no spleen are given antibiotics at the first sign of infection. Children who do not have a spleen should take antibiotics, usually penicillin or ampicillin, continuously until at least age 5 to prevent an infection in the bloodstream. If they also have an immunodeficiency disorder, they may take these antibiotics indefinitely.

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Selective Immunoglobulin Deficiency
Immunoglobulins are proteins that protect the body from infections. There are several types of immunoglobulins, and any one of them may be deficient in people with “selective immunoglobulin deficiency.” Which of the following is the most common immunoglobulin deficiency? 
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