Drug Treatment of Human Immunodeficiency Virus (HIV) Infection
Antiretroviral drugs used to treat human immunodeficiency virus (HIV) infection aim to do the following:
Several classes of antiretroviral drugs are used together to treat HIV infection. These drugs block HIV from entering human cells or block the activity of one of the enzymes HIV needs to replicate inside human cells and/or integrate its genetic material into human DNA.
The drugs are grouped into classes based on how they act against HIV:
Reverse transcriptase inhibitors prevent HIV reverse transcriptase from converting HIV RNA into DNA. There are three types of these drugs: nucleoside, nucleotide, and non-nucleoside.
Protease inhibitors prevent protease from activating certain proteins inside newly produced viruses. The result is immature, defective HIV that does not infect new cells.
Entry (fusion) inhibitors prevent HIV from entering cells. To enter a human cell, HIV must bind to a CD4 receptor and one other receptor, such as the CCR-5 receptor. One type of entry inhibitor, CCR-5 inhibitors, blocks the CCR-5 receptor, preventing HIV from entering human cells.
Post-attachment inhibitors also prevent HIV from entering cells but in a different way from fusion inhibitors. These are used mainly for HIV infection that is resistant to several other drugs.
Integrase inhibitors prevent HIV DNA from being integrated into human DNA.
These drugs prevent HIV from replicating in cells and dramatically reduce the amount of HIV in the blood over a few days to weeks. If replication is sufficiently slowed, the destruction of CD4+ lymphocytes by HIV is decreased and the CD4 count begins to increase. As a result, much of the damage to the immune system caused by HIV can be reversed. Doctors can detect this reversal by measuring the CD4 count, which begins to return toward normal levels over weeks to months. The CD4 count continues to increase for several years but at a slower rate.
Early diagnosis of HIV infection is important because it enables doctors to identify people with HIV infection before their CD4 cell count decreases too much. The sooner people start taking antiretroviral drugs, the more quickly their CD4 count is likely to increase and the higher the count is likely to become.
HIV invariably develops resistance to any of these drugs if they are used alone. Resistance develops after a few days to several months of use, depending on the drug and the virus. HIV becomes resistant to drugs because of mutations that occur when it replicates.
Treatment is most effective when two or more drugs are given in combination. These combinations of drugs are often referred to as combination antiretroviral therapy (cART). cART is used because
Combinations are more powerful than single drugs in reducing the amount of HIV in the blood.
Combinations help prevent the development of drug resistance.
Some HIV drugs (such as ritonavir) boost the blood levels of other HIV drugs (including most protease inhibitors) by slowing their removal from the body and thus increase their effectiveness.
cART can increase the CD4 count in HIV-infected people, thus strengthening their immune system and extending their life.
Side effects of combinations of antiretroviral drugs may be unpleasant and serious. However, doctors can prevent many serious problems (such as anemia, hepatitis, kidney problems, and pancreatitis) by regularly examining the person and doing blood tests. The blood tests can detect side effects before they become serious and enable doctors to change antiretroviral drugs when needed. For most people, doctors can find a combination of drugs with minimal side effects.
Metabolism of fats may be disturbed, probably primarily by protease inhibitors. The following may result:
This combination of problems (called metabolic syndrome) increases the risk of heart attacks, strokes, and dementia.
Rashes (skin reactions) are a side effect of many drugs. Some skin reactions can be very dangerous, especially if the drug causing the reaction is nevirapine or abacavir.
Mitochondria (structures within cells that generate energy) can be damaged when certain nucleoside reverse transcriptase inhibitors are used. Side effects include anemia, foot pain caused by nerve damage (neuropathy), liver damage that occasionally progresses to severe liver failure, and heart damage that can result in heart failure. Individual drugs differ in their tendency to cause these problems.
Bone density may decrease when cART is used, resulting in osteopenia or osteoporosis. Most people with these disorders do not have any symptoms, but they are at higher risk of fracturing a bone.
The immune reconstitution inflammatory syndrome (IRIS) sometimes occurs when cART is successful.
In IRIS, symptoms of various infections worsen or appear for the first time because immune responses improve (are reconstituted), increasing inflammation at sites of infection. Symptoms sometimes worsen because parts of dead viruses persist, triggering immune responses.
There are two forms of this syndrome:
Paradoxical IRIS typically occurs during the first few months of treatment and usually resolves on its own. If it does not, corticosteroids, given for a short time, are often effective. Paradoxical IRIS is more likely to cause symptoms and symptoms are more likely to be severe when cART is started soon after treatment of an opportunistic infection is started. Thus, for some (but not all) opportunistic infections, cART is delayed until treatment of the opportunistic infection has reduced or eliminated the infection.
In people with unmasked IRIS, doctors treat the newly identified opportunistic infection with antimicrobial drugs. Occasionally, when the symptoms are severe, corticosteroids are also used. Usually, when unmasked IRIS occurs, cART is continued. An exception is when a cryptococcal infection affects the brain. Then cART is temporarily interrupted until the infection is controlled.
Drug interactions between antiretroviral drugs and other drugs or between two antiretroviral drugs can occur. Thus, people should make sure their doctor knows all the drugs they are taking.
Interactions between antiretroviral drugs may increase or decrease the effectiveness of the drugs.
Also, other substances affect how the body uses some HIV drugs. These substances include the following:
Grapefruit juice increases the levels of saquinavir, increasing the risk of side effects.
St. John's wort (a medicinal herb) causes the body to process protease inhibitors and non-nucleoside reverse transcriptase inhibitors more quickly and thus makes them less effective.
Antiretroviral treatment is beneficial only if the drugs are taken on schedule. Missing doses allows the virus to replicate and develop resistance.
Treatment cannot eliminate the virus from the body, although the HIV level often decreases so much that it cannot be detected in blood or other fluids or tissues. An undetectable level is the goal of treatment. If treatment is stopped, the HIV level increases, and the CD4 count begins to fall.
The best time to start drug treatment is as soon as possible, even if people are not sick and their CD4 count is still above 500 (normal is 500 to 1,000). Doctors used to wait until the CD4 count was below 500 to start drug treatment. However, research has shown that people who are promptly treated with antiretroviral drugs are less likely to develop AIDS-related complications and to die of them.
Before starting a treatment regimen, people are taught about the necessity of the following:
Taking the drugs as directed for a life time is demanding. Some people skip doses or stop taking the drugs for a time (called a drug holiday). These practices are dangerous because they enable HIV to develop resistance to the drugs.
Because taking HIV drugs irregularly often leads to drug resistance, health care practitioners try to make sure that people are both willing and able to adhere to the treatment regimen. To simplify the drug schedule and to help people take the drugs as directed, doctors often prescribe treatment that combines two or more drugs in one tablet that can be taken only once a day.
Doctors may stop treatment temporarily if people develop another disorder that requires treatment or if side effects are severe and doctors must determine which drug is causing them. Stopping treatment is usually safe if all drugs are stopped at the same time. Drugs are restarted once the dose of the drug causing problems has been modified or another drug is substituted for it and doctors determine that it is safe to restart treatment. An exception is abacavir. If people have had a fever or rash when they were taking abacavir, the drug should be permanently stopped. Such people may have a severe, potentially fatal reaction to abacavir if they take it again.
Drugs for HIV Infection
If the CD4 count is low, drugs to prevent opportunistic infections are routinely prescribed, as in the following cases:
If the CD4 count drops below 50 cells per microliter of blood, azithromycin taken weekly or clarithromycin taken daily may prevent Mycobacterium avium complex infections. If people cannot take either of these drugs, they are given rifabutin.
If herpes simplex infections of the mouth, lips, genitals, or rectum recur, people may require prolonged treatment with an antiviral drug (such as acyclovir).
Other drugs may help with the weakness, weight loss, and central obesity that may result from HIV infection:
Megestrol and dronabinol (a marijuana derivative) stimulate appetite. Many people find that natural marijuana is even more effective, and its use for this purpose has been legalized in a few states.
If men have low testosterone levels plus fatigue, anemia, and/or muscle loss, they may be given testosterone by injection or through patches placed on the skin. Testosterone treatments can increase testosterone levels and lessen symptoms.
Growth hormone and tesamorelin (an injectable drug that releases growth hormone) reduce the central obesity that may result from HIV and its treatment.
If insulin resistance develops, drugs to increase sensitivity to insulin may help. If blood levels of cholesterol and triglycerides increase, lipid-lowering drugs (statins) can be used to lower them.