Merck Manual

Please confirm that you are not located inside the Russian Federation

honeypot link

Testicular Cancer


J. Ryan Mark

, MD, Sidney Kimmel Cancer Center at Thomas Jefferson University

Last full review/revision Aug 2019| Content last modified Jan 2020
Topic Resources
  • Testicular cancer is most common among young men but usually curable.

  • Usually a painless lump is present.

  • Ultrasonography and blood tests are done.

  • The testis is removed and radiation or chemotherapy may be given or additional surgery may be done.

Most testicular cancers develop in men younger than age 40. It is one of the most common cancers in young men, developing in about 9,600 men each year and causing about 410 deaths. Among the types of cancer that commonly develop in the testes are seminoma, teratoma, embryonal carcinoma, and choriocarcinoma.

The cause of testicular cancer is not known, but men whose testes did not descend into the scrotum (cryptorchidism Undescended Testes and Retractile Testes Undescended testes (cryptorchidism) are testes that remain in the abdomen or the groin instead of descending into the scrotum. Retractile testes (hypermobile testes) have descended into the... read more Undescended Testes and Retractile Testes ) by age 3 have a greater chance of developing testicular cancer than do men whose testes descended by that age. Cryptorchidism is best corrected surgically in childhood. Correcting cryptorchidism decreases the risk of testicular cancer. However, even if cryptorchidism is corrected, the risk of cancer is still higher than for men who never had cryptorchidism. Cancer can also occur in the other testis even if it descended normally. Sometimes in adults, doctors recommend removal of a single undescended testis to reduce the risk of cancer.

Symptoms of Testicular Cancer

Testicular cancer may cause an enlarged testis or a lump. A testis normally feels like a smooth oval, with the epididymis attached behind and on top. Testicular cancer causes a firm, growing lump in or attached to the testis. With cancer, the testis loses its normal shape, becoming large, irregular, or bumpy. Although testicular cancer is usually painless, the testis or lump may hurt when lightly touched and may even hurt without being touched. A firm lump on the testis requires prompt medical attention. Occasionally, blood vessels rupture within the tumor, yielding a suddenly enlarged, severely painful swelling.

Diagnosis of Testicular Cancer

  • Ultrasonography

  • Blood tests (alpha-fetoprotein, human chorionic gonadotropin)

Physical examination and ultrasonography Ultrasonography There are a variety of tests that can be used in the evaluation of a suspected kidney or urinary tract disorder. (See also Overview of the Urinary Tract.) X-rays are usually not helpful in evaluating... read more may indicate whether a lump is part of the testis and whether it is solid (and thus more likely to be cancer) or filled with fluid (cystic). Determining the blood levels of two proteins, alpha-fetoprotein and human chorionic gonadotropin, may help in making the diagnosis but is not definitive. The levels of these proteins often increase in men with testicular cancer. Additional testing, including a chest x-ray and computed tomography, may be done to determine whether the cancer has spread. Most doctors recommend that young men check their own testes for lumps about once per month.

Did You Know...

  • Loss of one testis does not impair sex drive or the ability to have children or erections.

Treatment of Testicular Cancer

  • Surgery

The initial treatment for testicular cancer is surgical removal of the entire affected testis (radical orchiectomy). An artificial testis (prosthesis) can be placed if the man desires. The other testis is not removed, so men retain adequate levels of male hormones and can remain fertile. Infertility sometimes occurs in men with testicular cancer, but fertility may return after treatment. Sperm banking may be possible before treatment.

With cancers other than seminomas, lymph nodes in the abdomen are also removed (retroperitoneal lymph node dissection) because the cancer often spreads there first. Radiation therapy may be curative for a seminoma.

A combination of surgery and chemotherapy often cures testicular cancer that has spread. Blood levels of alpha-fetoprotein and human chorionic gonadotropin that were elevated at diagnosis decline after successful treatment. If levels rise after treatment, the cancer may have recurred.

The prognosis for men with testicular cancer depends on the type and extent of the cancer but is usually excellent if the cancer has not spread. Even if the cancer has spread, cure is often possible.

Others also read
Test your knowledge
Kidney Infection
Pyelonephritis is an infection that affects one or both kidneys. Which of the following is the most likely cause of this infection?
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID

Also of Interest

Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID