The prevalence of prescription drug use increases substantially with age. Survey data from 2010–2011 indicated that almost 90% of ambulatory older adults regularly take at least 1 prescription medication, almost 80% regularly take at least 2 prescription medications, and 36% take at least 5 prescription medications (polypharmacy) ( 1 ). Subsequent survey data from 2020 indicated that the mean number of prescription medications taken by older adults had increased to approximately 4 prescription medications ( 2 ). Polypharmacy in older adults also increased to 43% from 2017 to 2020 and hyperpolypharmacy (taking at least 10 prescription medications) increased to 6.1%. When over-the-counter and dietary supplements are included, these prevalence rates increase substantially. Medication use is greatest among frail older adults, hospitalized patients, and nursing home residents.