Gaze palsies most commonly affect horizontal gaze; some affect upward gaze, and fewer affect downward gaze.
The underlying disorder is treated.
(See also Overview of Neuro-ophthalmologic and Cranial Nerve Disorders Overview of Neuro-ophthalmologic and Cranial Nerve Disorders Dysfunction of certain cranial nerves may affect the eye, pupil, optic nerve, or extraocular muscles and their nerves; thus, they can be considered cranial nerve disorders, neuro-ophthalmologic... read more .)
Horizontal gaze palsies
Conjugate horizontal gaze is controlled by neural input from the cerebral hemispheres, cerebellum, vestibular nuclei, and neck. Neural input from these sites converges at the horizontal gaze center (paramedian pontine reticular formation) and is integrated into a final command to the adjacent 6th cranial nerve (abducens) nucleus. The 6th cranial nucleus controls the lateral rectus on the same side and projects to the contralateral 3rd cranial nerve nucleus via the medial longitudinal fasciculus (MLF) to activate the medial rectus. Inhibitory signals to opposing eye muscles occur simultaneously.
The most common and devastating impairment of horizontal gaze results from pontine lesions that affect the horizontal gaze center and the 6th cranial nerve nucleus. Strokes Ischemic Stroke Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more are a common cause, resulting in loss of horizontal gaze ipsilateral to the lesion. In palsies due to stroke, the eyes may not move in response to any stimulus (eg, voluntary or vestibular). Milder palsies may cause only nystagmus or inability to maintain fixation.
Another common cause is a lesion in the contralateral cerebral hemisphere rostral to the precentral gyrus (called the frontal eye fields). These lesions are typically caused by a stroke. The resulting palsy usually abates with time. Horizontal conjugate gaze mediated by brain stem reflexes (eg, in response to cold-water caloric stimulation) is preserved.
Vertical gaze palsies
Upward and downward gaze depends on input from fiber pathways that ascend from the vestibular system through the MLF on both sides to the 3rd and 4th cranial nerve nuclei, the interstitial nucleus of Cajal, and the rostral interstitial nucleus of the MLF. A separate system descends, presumably from the cerebral hemispheres, through the midbrain pretectum to the 3rd and 4th cranial nerve nuclei. The rostral interstitial nucleus of the MLF integrates the neural input into a final command for vertical gaze, similar to the horizontal gaze center for horizontal gaze.
Vertical gaze becomes more limited with aging.
Vertical gaze palsies commonly result from midbrain lesions, usually infarcts and tumors. In upward vertical gaze palsies, the pupils may be dilated, and vertical nystagmus occurs during upward gaze.
Parinaud syndrome (dorsal midbrain syndrome), a conjugate upward vertical gaze palsy, may result from a pineal tumor that compresses the midbrain or, less commonly, a tumor or infarct of the midbrain pretectum. Parinaud syndrome is characterized by
Impaired upward gaze
Lid retraction (Collier sign)
Downward gaze preference (setting-sun sign)
Dilated pupils (about 6 mm) that respond poorly to light but better to accommodation (light-near dissociation)
Downward gaze palsies
Impaired voluntary vertical gaze, especially downward, with preservation of reflex vertical movements (doll's-eye maneuver) usually indicates progressive supranuclear palsy Progressive Supranuclear Palsy (PSP) Progressive supranuclear palsy is a rare, degenerative central nervous system disorder that progressively impairs voluntary eye movements and causes bradykinesia, muscular rigidity with progressive... read more ; other causes are rare.
Conjugate gaze palsies most commonly affect horizontal gaze; downward gaze is affected least often.
Common causes include strokes for horizontal gaze palsies, midbrain lesions (usually infarcts and tumors) for vertical gaze palsies, and progressive supranuclear palsy for downward gaze palsies.
Treat the underlying disorder.