Etiology of Ischemic Stroke
The following are the modifiable risk factors that contribute the most to increased risk of ischemic stroke:
Lack of physical activity
High-risk diet (eg, high in saturated fats, trans fats, and calories)
Heart disorders (particularly disorders that predispose to emboli, such as acute myocardial infarction Acute Myocardial Infarction (MI) Acute myocardial infarction is myocardial necrosis resulting from acute obstruction of a coronary artery. Symptoms include chest discomfort with or without dyspnea, nausea, and/or diaphoresis... read more , infective endocarditis Infective Endocarditis Infective endocarditis is infection of the endocardium, usually with bacteria (commonly, streptococci or staphylococci) or fungi. It may cause fever, heart murmurs, petechiae, anemia, embolic... read more , and atrial fibrillation Atrial Fibrillation and Wolff-Parkinson-White Syndrome (WPW) In Wolff-Parkinson-White syndrome, antegrade conduction occurs over an accessory pathway. If atrial fibrillation, develops this is a medical emergency as very rapid ventricular rates can develop... read more )
Carotid artery stenosis
Use of certain drugs (eg, cocaine, amphetamines)
Use of exogenous estrogen
Unmodifiable risk factors include the following:
Family history of stroke
The most common causes of ischemic stroke can be classified as
Cryptogenic (ie, no clear cardioembolic, lacunar, or atherosclerotic source; the most common classification)
Large-vessel atherosclerosis (the 4th most common cause)
Stroke is classified as cryptogenic when one of the following occurs:
The diagnostic evaluation is incomplete.
No cause is identified despite an extensive evaluation.
There is more than one probable cause (eg, atrial fibrillation and ipsilateral carotid stenosis).
Embolic stroke of undetermined source (ESUS), a subcategory of cryptogenic stroke, is diagnosed when no source has been identified after sufficient diagnostic evaluation has excluded lacunar stroke, major cardioembolic sources, and ipsilateral steno-occlusive vessel disease (> 50% occlusion). Recent evidence suggests that symptomatic nonstenotic carotid disease with < 50% occlusion may be an important a cause of stroke (1 Etiology references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ).
Emboli may lodge anywhere in the cerebral arterial tree.
Emboli may originate as cardiac thrombi, especially in the following conditions:
Rheumatic heart disease (usually mitral stenosis)
Vegetations on heart valves in bacterial or marantic endocarditis
Prosthetic heart valves
Mechanical circulatory assist devices (eg, left ventricular assist device, or LVAD [ 2 Etiology references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ])
Other sources include clots that form after open-heart surgery and atheromas in neck arteries or in the aortic arch. Rarely, emboli consist of fat (from fractured long bones), air (in decompression sickness Decompression Sickness Decompression sickness occurs when rapid pressure reduction (eg, during ascent from a dive, exit from a caisson or hyperbaric chamber, or ascent to altitude) causes gas previously dissolved... read more ), or venous clots that pass from the right to the left side of the heart through a patent foramen ovale with shunt (paradoxical emboli). Emboli may dislodge spontaneously or after invasive cardiovascular procedures (eg, catheterization). Rarely, thrombosis of the subclavian artery results in embolic stroke in the vertebral artery or its branches.
Ischemic stroke can also result from lacunar infarcts. These small (≤ 1.5 cm) infarcts result from nonatherothrombotic obstruction of small, perforating arteries that supply deep cortical structures; the usual cause is lipohyalinosis (degeneration of the media of small arteries and replacement by lipids and collagen). Emboli may cause lacunar infarcts. Lacunar strokes >1.5 cm in patients without cardiovascular risk factors (eg, hypertension, diabetes, smoking) suggest a central embolic source.
Lacunar infarcts tend to occur in patients with diabetes or poorly controlled hypertension.
Large-vessel atherosclerosis can affect intracranial or extracranial arteries.
Atheromas, particularly if ulcerated, predispose to thrombi. Atheromas can occur in any major cerebral artery and are common at areas of turbulent flow, particularly at the carotid bifurcation. Partial or complete thrombotic occlusion occurs most often at the main trunk of the middle cerebral artery and its branches but is also common in the large arteries at the base of the brain, in deep perforating arteries, and in small cortical branches. The basilar artery and the segment of the internal carotid artery between the cavernous sinus and supraclinoid process are often occluded.
Less common causes of stroke include vascular inflammation secondary to disorders such as acute or chronic meningitis Overview of Meningitis Meningitis is inflammation of the meninges and subarachnoid space. It may result from infections, other disorders, or reactions to drugs. Severity and acuity vary. Findings typically include... read more , vasculitic disorders Overview of Vasculitis Vasculitis is inflammation of blood vessels, often with ischemia, necrosis, and organ inflammation. Vasculitis can affect any blood vessel—arteries, arterioles, veins, venules, or capillaries... read more , and syphilis Syphilis Syphilis is caused by the spirochete Treponema pallidum and is characterized by 3 sequential symptomatic stages separated by periods of asymptomatic latent infection. Common manifestations... read more ; dissection of intracranial arteries or the aorta; hypercoagulability disorders (eg, antiphospholipid syndrome Antiphospholipid Syndrome (APS) Antiphospholipid syndrome is an autoimmune disorder characterized by venous and arterial thrombosis or pregnancy complications (eg, recurrent miscarriage) and persistent autoantibodies to phospholipid-bound... read more , hyperhomocysteinemia Hyperhomocysteinemia Hyperhomocysteinemia may predispose to arterial and venous thrombosis. (See also Overview of Thrombotic Disorders.) Hyperhomocysteinemia may predispose to arterial thrombosis and venous thromboembolism... read more , underlying malignancy); hyperviscosity disorders (eg, polycythemia Polycythemia Vera Polycythemia vera is a chronic myeloproliferative neoplasm characterized by an increase in morphologically normal red cells (its hallmark), but also white cells and platelets. Ten to 15% of... read more , thrombocytosis Reactive Thrombocytosis (Secondary Thrombocythemia) Reactive thrombocytosis is an elevated platelet count (> 450,000/mcL [> 450 × 109/L]) that develops secondary to another disorder. (See also Overview of Myeloproliferative Neoplasms... read more , hemoglobinopathies Overview of Hemoglobinopathies Hemoglobinopathies are genetic disorders affecting the structure or production of the hemoglobin molecule. Hemoglobin molecules consist of polypeptide chains whose chemical structure is genetically... read more , plasma cell disorders Overview of Plasma Cell Disorders Plasma cell disorders are a diverse group of disorders of unknown etiology characterized by Disproportionate proliferation of a single clone of B cells Presence of a structurally and electrophoretically... read more ); and rare disorders (eg, fibromuscular dysplasia, moyamoya disease, Binswanger disease).
In children, sickle cell disease Sickle Cell Disease Sickle cell disease (a hemoglobinopathy) causes a chronic hemolytic anemia occurring almost exclusively in people with African ancestry. It is caused by homozygous inheritance of genes for hemoglobin... read more is a common cause of ischemic stroke.
Any factor that impairs systemic perfusion (eg, carbon monoxide toxicity, severe anemia or hypoxia, polycythemia, hypotension) increases risk of all types of ischemic strokes. A stroke may occur along the borders between territories of arteries (watershed areas); in such areas, blood supply is normally low, particularly if patients have hypotension and/or if major cerebral arteries are stenotic.
Less commonly, ischemic stroke results from vasospasm (eg, during migraine, after subarachnoid hemorrhage, after use of sympathomimetic drugs such as cocaine or amphetamines) or venous sinus thrombosis (eg, during intracranial infection, postoperatively, peripartum, secondary to a hypercoagulability disorder).
1. Ospel JM, Kappelhof M, Ganesh A, et al: Symptomatic non-stenotic carotid disease: current challenges and opportunities for diagnosis and treatment. J Neurointerv Surg jnis-2022-020005, 2023.. doi: 10.1136/jnis-2022-020005 Online ahead of print.
2. Caprio FZ, Sorond FA: Cerebrovascular disease: Primary and secondary stroke Prevention. Med Clin North Am 103 (2):295–308, 2019. doi: 10.1016/j.mcna.2018.10.001 Epub 2018 Nov 28.
Pathophysiology of Ischemic Stroke
Inadequate blood flow in a single brain artery can often be compensated for by an efficient collateral system, particularly between the carotid and vertebral arteries via anastomoses at the circle of Willis and, to a lesser extent, between major arteries supplying the cerebral hemispheres. However, normal variations in the circle of Willis and in the caliber of various collateral vessels, atherosclerosis, and other acquired arterial lesions can interfere with collateral flow, increasing the chance that blockage of one artery will cause brain ischemia.
Some neurons die when perfusion is < 5% of normal for > 5 minutes; however, the extent of damage depends on the severity of ischemia. If it is mild, damage proceeds slowly; thus, even if perfusion is 40% of normal, 3 to 6 hours may elapse before brain tissue is completely lost. However, if severe ischemia persists > 15 to 30 minutes, all of the affected tissue dies (infarction). Damage occurs more rapidly during hyperthermia and more slowly during hypothermia. If tissues are ischemic but not yet irreversibly damaged, promptly restoring blood flow may reduce or reverse injury. For example, intervention may be able to salvage the moderately ischemic areas (penumbras) that often surround areas of severe ischemia; penumbras exist because of collateral flow.
Mechanisms of ischemic injury include
Programmed cell death (apoptosis)
Infarction with cell necrosis
Inflammatory mediators (eg, interleukin1-beta, tumor necrosis factor-alpha) contribute to edema and microvascular thrombosis. Edema, if severe or extensive, can increase intracranial pressure.
Many factors may contribute to necrotic cell death; they include loss of adenosine triphosphate (ATP) stores, loss of ionic homeostasis (including intracellular calcium accumulation), lipid peroxidative damage to cell membranes by free radicals (an iron-mediated process), excitatory neurotoxins (eg, glutamate), and intracellular acidosis due to accumulation of lactate.
Symptoms and Signs of Ischemic Stroke
Symptoms and signs of ischemic stroke depend on the part of brain affected. Patterns of neurologic deficits often suggest the affected artery (see table ), but correlation is often inexact.
Deficits may become maximal within several minutes of onset, typically in embolic stroke. Less often, deficits evolve slowly, usually over 24 to 48 hours (called evolving stroke or stroke in evolution), typically in atherothrombotic stroke.
In most evolving strokes, unilateral neurologic dysfunction (often beginning in one arm, then spreading ipsilaterally) extends without causing headache, pain, or fever. Progression is usually stepwise, interrupted by periods of stability.
A stroke is considered submaximal when after it is complete, there is residual function in the affected area, suggesting viable tissue at risk of damage.
Embolic strokes often occur during the day; headache may precede neurologic deficits. Thrombi tend to occur during the night and thus are first noticed on awakening.
Lacunar infarcts may produce one of the classic lacunar syndromes (eg, pure motor hemiparesis, pure sensory hemianesthesia, combined hemiparesis and hemianesthesia, ataxic hemiparesis, dysarthria–clumsy hand syndrome); signs of cortical dysfunction (eg, aphasia) are absent. Multiple lacunar infarcts may result in multi-infarct dementia Vascular Cognitive Impairment and Dementia Vascular cognitive impairment and dementia is acute or chronic cognitive deterioration due to diffuse or focal cerebral infarction that is most often related to cerebrovascular disease. (See... read more .
A seizure may occur at stroke onset, more often with embolic than thrombotic stroke. Seizures may also occur months to years later; late seizures result from scarring or hemosiderin deposition at the site of ischemia.
Occasionally, fever develops.
Deterioration during the first 48 to 72 hours after onset of symptoms, particularly progressively impaired consciousness, results more often from cerebral edema than from extension of the infarct. Unless the infarct is large or extensive, function commonly improves within the first few days; further improvement occurs gradually for up to 1 year.
Diagnosis of Ischemic Stroke
Primarily clinical evaluation
Neuroimaging and bedside glucose testing
Evaluation to identify the cause
Diagnosis of ischemic stroke is suggested by sudden neurologic deficits referable to a specific arterial territory. Ischemic stroke must be distinguished from other causes of similar focal deficits (sometimes called stroke mimics, which are non-cerebrovascular disorders that cause focal neurologic signs (eg, hypoglycemia Hypoglycemia Hypoglycemia, or low plasma glucose level can result in sympathetic nervous system stimulation and central nervous system dysfunction. In patients with diabetes who take insulin or antihyperglycemic... read more ), such as
Seizures (eg, with postictal paralysis)
Functional neurologic disorders (generally a diagnosis of exclusion)
Headache, coma or stupor, and vomiting are more likely with hemorrhagic stroke than with an ischemic stroke.
When stroke is suspected, clinicians may use standardized criteria to grade severity and follow changes over time. This approach can be particularly useful as an outcome measure in efficacy studies. The National Institutes of Health Stroke Scale (NIHSS) is a 15-item scale to evaluate the patient's level of consciousness and language function and to identify motor and sensory deficits by asking the patient to answer questions and to perform physical and mental tasks. It is also useful for choosing appropriate treatment and predicting outcome.
Evaluation of ischemic stroke requires assessment of the brain parenchyma, vascular system (including the heart and large arteries), and blood.
Differentiating clinically between the types of stroke is imprecise; however, some clues based on symptom progression, time of onset, and type of deficit can help.
Although diagnosis is clinical, neuroimaging and bedside glucose testing are mandatory.
Distinction between lacunar, embolic, and thrombotic stroke based on history, examination, and neuroimaging is not always reliable, so tests to identify common or treatable causes and risk factors for all of these types of strokes are routinely done. Patients should be evaluated for the following categories of causes and risk factors:
Cardiac (eg, atrial fibrillation, potential structural sources of emboli)
Vascular (eg, critical arterial stenosis detected by vascular imaging)
Blood (eg, diabetes, dyslipidemia, hypercoagulability)
A cause cannot be identified for cryptogenic strokes.
Neuroimaging with CT or MRI is done first to exclude intracerebral hemorrhage, subdural or epidural hematoma, and a rapidly growing, bleeding, or suddenly symptomatic tumor. CT evidence of even a large anterior circulation ischemic stroke may be subtle during the first few hours; changes may include effacement of sulci or the insular cortical ribbon, loss of the gray-white junction between cortex and white matter, and a dense middle cerebral artery sign. Within 6 to 12 hours of ischemia, medium-sized to large infarcts start to become visible as hypodensities; small infarcts (eg, lacunar infarcts) may be visible only with MRI.
Diffusion-weighted MRI (highly sensitive for early ischemia) can be done immediately after initial CT neuroimaging.
For cardiac causes, testing typically includes ECG, telemetry or Holter monitoring, serum troponin, and transthoracic or transesophageal echocardiography. Implantable cardiac monitors are useful for detecting underlying atrial arrhythmias in patients with cryptogenic stroke (1 Diagnosis reference Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ).
For vascular causes, testing may include magnetic resonance angiography (MRA), CT angiography (CTA), carotid and transcranial duplex ultrasonography, and conventional angiography. The choice and sequence of testing is individualized, based on clinical findings. MRA, CTA, and carotid ultrasonography all show the anterior circulation; however, MRA and CTA provide better images of the posterior circulation than carotid ultrasonography. In general, CTA is preferred to MRA because motion artifacts are avoided. Usually, CTA or MRA should be done urgently but should not delay treatment with IV tPA if it is indicated.
For blood-related causes (eg, t hrombotic disorders Overview of Thrombotic Disorders In healthy people, homeostatic balance exists between procoagulant (clotting) forces and anticoagulant and fibrinolytic forces. Numerous genetic, acquired, and environmental factors can tip... read more ), blood tests are done to assess their contribution and that of other causes. Routine testing typically includes complete blood count (CBC), metabolic panel, prothrombin time/partial thromboplastin time (PT/PTT), fasting blood glucose, hemoglobin A1C, and lipid profile.
Depending on which causes are clinically suspected, additional tests may include measurement of homocysteine, testing for thrombotic disorders (antiphospholipid antibodies, protein S, protein C, antithrombin III, factor V Leiden), testing for rheumatic disorders (eg, antinuclear antibodies, rheumatoid factor, erythrocyte sedimentation rate), syphilis serologic testing, hemoglobin electrophoresis, and a urine drug screen for cocaine and amphetamines.
Treatment of Ischemic Stroke
General stroke treatments
Acute antihypertensive therapy only in certain circumstances
For acute treatment, sometimes reperfusion with recombinant tissue plasminogen activator or tenecteplase and/or mechanical thrombectomy
Sometimes carotid endarterectomy or stenting
Long-term control of risk factors
For long-term treatment, rehabilitation
Acute stroke treatment
Guidelines for early management of stroke are available from the American Heart Association and American Stroke Association. Patients with acute ischemic strokes are usually hospitalized.
Supportive measures Treatment Strokes are a heterogeneous group of disorders involving sudden, focal interruption of cerebral blood flow that causes neurologic deficit. Strokes can be Ischemic (80%), typically resulting... read more such as the following may be needed during initial evaluation and stabilization.
Airway support and ventilatory assistance if decreased consciousness or bulbar dysfunction compromises the airway
Supplemental oxygen only if needed to maintain oxygen saturation > 94%
Correction of hyperthermia (temperature > 38° C) by using an antipyretic medication and identifying and treating the cause of hypothermia
Treatment of hypoglycemia (blood glucose < 60 mg/dL)
Treatment of hyperglycemia to lower blood glucose to 140 to 180 mg/dL while closely monitoring for hypoglycemia
Perfusion of an ischemic brain area may require a high blood pressure (BP) because autoregulation is lost; thus, BP should not be decreased except in the following cases:
There are signs of other end-organ damage (eg, aortic dissection Aortic Dissection Aortic dissection is the surging of blood through a tear in the aortic intima with separation of the intima and media and creation of a false lumen (channel). The intimal tear may be a primary... read more , acute myocardial infarction Acute Myocardial Infarction (MI) Acute myocardial infarction is myocardial necrosis resulting from acute obstruction of a coronary artery. Symptoms include chest discomfort with or without dyspnea, nausea, and/or diaphoresis... read more , pulmonary edema, hypertensive encephalopathy, retinal hemorrhages, acute renal failure Acute Kidney Injury (AKI) Acute kidney injury is a rapid decrease in renal function over days to weeks, causing an accumulation of nitrogenous products in the blood (azotemia) with or without reduction in amount of urine... read more ).
Use of recombinant tissue plasminogen activator (tPA) and/or mechanical thrombectomy is likely.
If BP is ≥ 220 mm Hg systolic or ≥ 120 mm Hg diastolic on 2 successive readings 15 minutes apart, lowering BP by 15% in the 24 hours after stroke onset is reasonable.
For patients who are eligible for acute reperfusion therapy, BP is treated to decrease it to < 180/105 mm Hg before starting IV thrombolysis with one of the following:
Labetalol 10 to 20 mg IV bolus over 1 to 2 minutes (may repeat 1 time)
Nicardipine 5 mg/hour IV infusion initially (dose is increased by 2.5 mg/hour every 5 to 15 minutes to a maximum of 15 mg/hour)
Clevidipine 1 to 2 mg/hour IV infusion (titrate by doubling the dose every 2 to 5 minutes until desired BP is reached to a maximum of 21 mg/hour)
Patients with presumed thrombi or emboli may be treated with one or a combination of the following:
tPA, thrombolysis-in-situ, and/or mechanical thrombectomy
Most patients are not candidates for thrombolytic therapy; they should be given an antiplatelet medication (usually aspirin 325 mg orally) when they are admitted to the hospital. Contraindications to antiplatelet medications include aspirin-induced or nonsteroidal anti-inflammatory drug (NSAID)-induced asthma or urticaria, other hypersensitivity to aspirin or to tartrazine, acute gastrointestinal bleeding, glucose-6-phosphate dehydrogenase (G6PD) deficiency, and use of warfarin.
Recombinant tPA (alteplase) can be used for patients with acute ischemic stroke up to 3 hours after symptom onset if they have no contraindications to tPA (see table ). Some experts recommend using tPA up to 4.5 hours after symptom onset (see Expansion of the Time Window for Treatment of Acute Ischemic Stroke With Intravenous Tissue Plasminogen Activator); however, between 3 hours and 4.5 hours after symptom onset, additional exclusion criteria apply (see table ). Thus, tPA must be given within 4.5 hours of symptom onset—a difficult requirement. Because the precise time of symptom onset may not be known, clinicians must start timing from the moment the patient was last observed to be well.
Although tPA can cause fatal or other symptomatic brain hemorrhage, patients treated with tPA strictly according to protocols still have a higher likelihood of functional neurologic recovery. Only clinicians experienced in stroke management should use tPA to treat patients with acute stroke; inexperienced physicians are more likely to violate protocols, resulting in more brain hemorrhages and deaths. When tPA is given incorrectly (eg, when given despite the presence of exclusion criteria), risk of hemorrhage due to tPA is high mainly for patients who have had stroke; risk of brain hemorrhage is very low (about 0.5%; 95% confidence interval of 0 to 2.0% [ 1 Treatment references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ]) for patients who have had a stroke mimic (eg, hemiplegic migraine, certain CNS infections, postictal paralysis, functional neurologic disorders). If experienced clinicians are not available on site, consultation with an expert at a stroke center (including video evaluation of the patient [telemedicine]), if possible, may enable these clinicians to use tPA. Because most poor outcomes result from failure to strictly adhere to the protocol, a checklist of inclusion and exclusion criteria should be used.
Before treatment with tPA, the following are required:
Brain hemorrhage must be excluded by CT
Systolic BP must be < 185 mm Hg
Diastolic BP must be < 105 mm Hg
Blood glucose must be > 50 mg/dL
Antihypertensives (IV nicardipine, IV labetalol, IV clevidipine) may be given as above. BP should be kept < 180/105 mm Hg for at least 24 hours after treatment with tPA.
Dose of tPA is 0.9 mg/kg IV (maximum dose 90 mg); 10% is given by rapid IV injection over 1 minute, and the remainder by constant infusion over 60 minutes. Vital signs are closely monitored for 24 hours after treatment. Any bleeding complications are aggressively managed. Anticoagulants and antiplatelet medications are not used within 24 hours of treatment with tPA.
Recent evidence supports tenecteplase as a reasonable alternative to alteplase (2 Acute stroke treatment ). Tenecteplase differs from alteplase by three amino acids in its glycoprotein structure. Although there is no significant difference in outcomes or adverse events, rates of reperfusion are higher in patients treated with tenecteplase. Compared with alteplase, tenecteplase has greater fibrin binding, increased conversion of plasminogen to plasmin, greater resistance to plasminogen activator inhibitor, and easier administration as a single bolus.
Retrospective analyses have led to narrowing the list of absolute contraindications to using alteplase in the therapeutic window after onset of stroke symptoms (3 Treatment references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ). Nevertheless, if patients have any of the following conditions, the risk of bleeding with alteplase (tPA) is increased and should be weighed against the anticipated benefits [ 4 Treatment references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ]):
Recent major surgery or procedure (eg, coronary artery bypass graft, obstetrical delivery, organ biopsy, previous puncture of noncompressible vessels)
Recent intracranial hemorrhage
Recent gastrointestinal or genitourinary bleeding
Hypertension (systolic BP > 175 mm Hg or diastolic BP > 110 mm Hg
Subacute bacterial endocarditis
Hemostatic defects including those due to severe hepatic or renal disease
Significant hepatic dysfunction
Hemorrhagic diabetic retinopathy or other hemorrhagic ophthalmic conditions
Septic thrombophlebitis or occluded arteriovenous cannula at an infected site
Advanced age (> 77 years)
Current use of anticoagulants (eg, warfarin)
Thrombolysis-in-situ (angiographically directed intra-arterial thrombolysis) of a thrombus or embolus is almost obsolete except when a clot is too distal to be accessed by catheters (eg, distal A2 [anterior cerebral artery distal to the anterior communicating artery]).
Mechanical thrombectomy (angiographically directed intra-arterial removal of a thrombus or embolus by a stent retriever device) is standard of care in large stroke centers for patients with recent large-vessel occlusion in the anterior circulation.
Mechanical thrombectomy had previously been restricted to use within 6 hours of symptom onset in patients with internal carotid artery or middle cerebral artery occlusion. However, at comprehensive stroke centers, clinical and/or imaging findings that suggest a substantial amount of tissue at risk of infarction (penumbra) may justify later treatment. For example, the volume of infarcted tissue and at-risk underperfused tissue (ischemic penumbra) can be identified using perfusion CT or perfusion MRI. A sizeable mismatch between the infarct and at-risk volume identified by diffusion-weighted or perfusion-weighted imaging suggests that substantial penumbra is still potentially salvageable. In the DEFUSE 3 trial, benefit was evident up to 16 hours after symptom onset in patients with a small infarct and a larger penumbra; both findings are based on imaging criteria (5 Treatment references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ). In the DAWN trial, benefit was evident up to 24 hours after symptom onset in patients with a large mismatch between infarct volume based on imaging and severity of the clinical deficit based on clinical criteria (6 Treatment references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ); this finding suggests that salvageable penumbra is present.
Recently, evidence for the efficacy of mechanical thrombectomy in patients with posterior circulation strokes has been growing (7 Treatment references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ).
In the past, clinical trials restricted mechanical thrombectomy to patients with an NIHSS score > 6; however, recent evidence supports the usefulness of mechanical thrombectomy in patients with an NIHSS < 6 (8 Treatment references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ).
Current evidence supports the use of mechanical thrombectomy with IV thrombolysis (bridging therapy) for all patients who are otherwise eligible for thrombolysis (9 Treatment references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ). It should not be used as an alternative to IV recombinant tPA for patients with acute ischemic stroke if they are eligible for tPA. Devices used to remove thrombi are being improved, and recent models reestablish perfusion in 90 to 100% of patients.
Oral antiplatelet medications are used in acute stroke treatment to reduce the risk of recurrent disabling stroke. The following may be used:
Aspirin 81 to 325 mg within 48 hours of stroke onset
Dual antiplatelet therapy with aspirin plus clopidogrel: Aspirin plus clopidogrel (eg, 300 to 600 mg orally once, then 75 mg orally once a day) within 24 hours of stroke onset for patients with minor stroke or at high risk of a transient ischemic attack (TIA; ABCD2 score ≥ 4)
Dual antiplatelet therapy with aspirin 81 mg and ticagrelor with a loading dose of 180 mg on day 1 followed by 90 mg twice a day (possibly beneficial for patients with clopidogrel resistance CYP2C19 loss of function allele, especially if an extracranial or intracranial stent is used)
Aspirin given within 48 hours reduces the risk of early recurrent stroke and death (10 Treatment references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ).
If patients have had a TIA or minor stroke, clopidogrel plus aspirin given within 24 hours of symptom onset and continued for 21 days appears more effective than aspirin alone for reducing risk of stroke in the first 90 days and does not increase risk of hemorrhage (11 Treatment references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ). However, prolonged (eg, > 3 months) use of clopidogrel plus aspirin is avoided because it has no advantage over aspirin alone in long-term secondary stroke prevention and results in more bleeding complications. Dual antiplatelet therapy with aspirin and ticagrelor can be used in patients with clopidogrel resistance due to the presence of the CYP2C19 loss of function allele.
Anticoagulation with heparin or low molecular weight heparin is used for stroke caused by cerebral venous thrombosis and sometimes for stroke caused by cervical artery dissection. Anticoagulation can also be used in patients at high risk of recurrent cardiac emboli (eg, those with cardiac thrombi or mechanical valves).
Usually, anticoagulation is avoided in the acute stage because risk of hemorrhage (hemorrhagic transformation) is higher, especially with large infarcts.
Long-term stroke treatment
Supportive care is continued during convalescence:
Controlling hyperglycemia and fever can limit brain damage after stroke, leading to better functional outcomes.
Screening for dysphagia before patients begin eating, drinking, or receiving oral medications can help identify patients at increased risk of aspiration; it should be done by a speech-language pathologist or other trained health care practitioner.
Enteral nutrition if needed should be started within 7 days of admission after an acute stoke.
Intermittent pneumatic compression (IPC) for deep venous thrombosis prophylaxis Prevention Deep venous thrombosis (DVT) is clotting of blood in a deep vein of an extremity (usually calf or thigh) or the pelvis. DVT is the primary cause of pulmonary embolism. DVT results from conditions... read more is recommended for immobile stroke patients without contraindications.
Low molecular weight heparin may be given to immobile stroke patients without contraindications.
Physical therapy to help maximize function and prevent sarcopenia and joint contractures
Long-term management also focuses on prevention of recurrent stroke (secondary prevention). Modifiable risk factors (eg, hypertension Hypertension Hypertension is sustained elevation of resting systolic blood pressure (≥ 130 mm Hg), diastolic blood pressure (≥ 80 mm Hg), or both. Hypertension with no known cause (primary; formerly, essential... read more , diabetes Diabetes Mellitus (DM) Diabetes mellitus is impaired insulin secretion and variable degrees of peripheral insulin resistance leading to hyperglycemia. Early symptoms are related to hyperglycemia and include polydipsia... read more , smoking Smoking Cessation Most people who smoke want to quit and have tried doing so with limited success. Effective interventions include cessation counseling and pharmacologic treatment, such as varenicline, bupropion... read more , alcohol use disorder Alcohol Use Disorder and Rehabilitation Alcohol use disorder involves a pattern of alcohol use that typically includes craving and manifestations of tolerance and/or withdrawal along with adverse psychosocial consequences. Alcoholism... read more , dyslipidemia Dyslipidemia Dyslipidemia is elevation of plasma cholesterol, triglycerides (TGs), or both, or a low high-density lipoprotein cholesterol (HDL-C) level that contributes to the development of atherosclerosis... read more , obesity Obesity Obesity is a chronic, multifactorial, relapsing disorder characterized by excess body weight and defined as a body mass index (BMI) of ≥ 30 kg/m2. Complications include cardiovascular disorders... read more ) are treated. Reducing systolic BP may be more effective when the target BP is < 120 mm Hg rather than the typical level (< 140 mm Hg). The timeline for reducing BP to these levels should be determined based on the each patient's health status and risk of recurrent stroke or other cardiovascular events.
Depression Diagnosis Depressive disorders are characterized by sadness severe enough or persistent enough to interfere with function and often by decreased interest or pleasure in activities. Exact cause is unknown... read more often occurs after a stroke and may interfere with recovery. Treatment of depression may aid in recovery, Clinicians should ask patients whether they are feeling sad or have lost interest or pleasure in doing formerly enjoyable activities. Clinicians should also ask family members whether they have noticed any signs of depression in the patient.
Extracranial carotid endarterectomy or stenting is indicated for patients with recent nondisabling, submaximal stroke attributed to an ipsilateral carotid obstruction of 70 to 99% of the arterial lumen or to an ulcerated plaque if life expectancy is at least 5 years. In other symptomatic patients (eg, patients with TIAs), endarterectomy or stenting with antiplatelet therapy is indicated for carotid obstruction of ≥ 60% with or without ulceration if life expectancy is at least 5 years. These procedures should be done by surgeons and interventionists who have a successful record with the procedure (ie, morbidity and mortality rate of < 3%) in the hospital where it will be done. If carotid stenosis is asymptomatic, endarterectomy or stenting is beneficial only when done by very experienced surgeons or interventionists, and that benefit is likely to be small. For many patients, carotid stenting with an emboli-protection device (a type of filter) is preferred to endarterectomy, particularly if patients are ≥ 70 years and have a high surgical risk. Carotid endarterectomy and stenting are equally effective for stroke prevention. In the periprocedural period, myocardial infarction is more likely after endarterectomy, and recurrent stroke is more likely after stenting.
Extracranial vertebral angioplasty and/or stenting can be used in certain patients with recurrent symptoms of vertebrobasilar ischemia despite optimal medical treatment and a vertebral artery obstruction of 50 to 99%.
Intracranial major artery angioplasty and/or stenting may be effective in patients when optimal treatment with medications has been ineffective. Key factors to consider are patient characteristics (eg, control of risk factors, adherence to the medication regimen), timing of the procedure (> 3 weeks after the stroke), and the interventionist's experience. Recent evidence indicates that the rate of periprocedural adverse events can be acceptably low after percutaneous transluminal angioplasty and stenting when these factors are considered (12 Treatment references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ).
Endovascular closure of a patent foramen ovale plus use of antiplatelet therapy is recommended for patients < 60 years with an embolic stroke of undetermined cause despite extensive evaluation (13 Treatment references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more , 14 Treatment references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ).
Oral antiplatelet medications are used to prevent subsequent noncardioembolic (atherothrombotic, lacunar, cryptogenic) strokes (secondary prevention). The following may be used:
Aspirin 81 or 325 mg once a day
Clopidogrel 75 mg once a day
Ticagrelor 90 mg twice a day
The combination product aspirin 25 mg/extended-release dipyridamole 200 mg 2 times a day
In patients taking warfarin, antiplatelet medications additively increase risk of bleeding and are thus usually avoided; however, aspirin is occasionally used simultaneously with warfarin in certain high-risk patients. Clopidogrel is indicated for patients who are allergic to aspirin. If ischemic stroke recurs or if a coronary artery stent becomes blocked while patients are taking clopidogrel, clinicians should suspect impaired metabolism of clopidogrel (ineffective conversion of clopidogrel to its active form because cytochrome P-450 2C19 [CYP2C19] activity is reduced); a test to determine CYP2C19 status (eg, genetic testing for CYP450 polymorphisms) is recommended. If impaired metabolism is confirmed, aspirin or combination aspirin and ticagrelor is a reasonable alternative.
Clopidogrel plus aspirin, if started during acute treatment, is given for only a short time (eg, < 3 weeks) because it has no advantage over aspirin alone in long-term secondary stroke prevention and results in more bleeding complications. Clopidogrel plus aspirin before and for ≥ 30 days after stenting is indicated, usually for ≤ 6 months; if patients cannot tolerate clopidogrel or have clopidogrel resistance due to CYP2C19 loss of allele, ticagrelor 90 mg twice a day can be substituted.
Oral anticoagulants are indicated for secondary prevention of cardioembolic strokes (as well as primary prevention). Adjusted-dose warfarin (a vitamin K antagonist) with a target international normalized ratio (INR) of 2 to 3 is used for certain patients with nonvalvular or valvular atrial fibrillation. A target INR of 2.5 to 3.5 is used if patients have a mechanical prosthetic cardiac valve. Efficacious alternatives to warfarin for patients with nonvalvular atrial fibrillation include the following new anticoagulants:
Dabigatran (a direct thrombin inhibitor) 150 mg twice a day in patients without severe renal failure (creatinine clearance < 15 mL/minute) and/or liver failure (elevated INR)
Apixaban (a direct factor Xa inhibitor) 5 mg twice a day; 2.5 mg if patients have ≥ 2 of the following: age > 80 years, weight < 60 kg, serum creatinine ≥ 1.5mg/dL
Rivaroxaban (a direct factor Xa inhibitor) 20 mg once a day for patients without severe renal failure (creatinine clearance < 15 mL/minute)
The main advantage of these newer anticoagulants is ease of use (eg, no need to check anticoagulation level with a blood test after the initial dose or to use a parenteral anticoagulant such as unfractionated heparin given by continuous infusion when transitioning from parenteral to oral anticoagulants). Their main disadvantage is cost. In case a hemorrhagic complication occurs, the antidote for dabigatran is idarucizumab (13 Treatment references Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes... read more ), and the antidote for apixaban or rivaroxaban is andexanet alfa. Efficacy and safety of combining any of these new anticoagulants with an antiplatelet medication have not been established.
Statins are used to prevent recurrent strokes; lipid levels must be decreased by substantial amounts. Atorvastatin 80 mg or rosuvastatin 40 mg once a day is recommended for patients with evidence of atherosclerotic stroke and LDL (low-density lipoprotein) cholesterol ≥ 100 mg/dL. A reasonable LDL cholesterol target is a 50% reduction or a level of < 70 mg/dL. Other statins (eg, simvastatin, pravastatin) may be also used.
1. Tsivgoulis G, Zand R, Katsanos AH, et al: Safety of intravenous thrombolysis in stroke mimics: prospective 5-year study and comprehensive meta-analysis. Stroke 46 (5):1281–1287, 2015. doi: 10.1161/STROKEAHA.115.009012
2. Menon BK, Singh N, Sylaja, PN: Tenecteplase use in patients with acute ischaemic stroke. Lancet 25;401(10377):618–619, 2023. doi: 10.1016/S0140-6736(22)02633-2 Epub 2023 Feb 9.
3. Frank B, Grotta JC,.Alexandrov AV, et al: Thrombolysis in stroke despite contraindications or warnings? Stroke 44 (3):727–733, 2013. doi: 10.1161/STROKEAHA.112.674622 Epub 2013 Feb 6.
4. Highlights of prescribing information for alteplase. Accessed 6/17/23.
5. Albers GW, Marks MP, Kemp S, et al: Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med 378 (8):708–718, 2018. doi: 10.1056/NEJMoa1713973 Epub 2018 Jan 24.
6. Nogueira RG, Jadhav AP, Haussen DC, et al: Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med 378 (1):11–21, 2018. doi: 10.1056/NEJMoa1706442 Epub 2017 Nov 11.
7. Jovin TG, Li C, Wu L, et al: Trial of thrombectomy 6 to 24 hours after stroke due to basilar-artery occlusion. N Engl J Med 2022; 387:1373-1384, 2022. doi: 10.1056/NEJMoa2207576
8. Abecassis IJ, Almallouhi E, Chalhoub R, et al: Outcomes after endovascular mechanical thrombectomy for low compared to high National Institutes of Health Stroke Scale (NIHSS): A multicenter study. Clin Neurol Neurosurg 225:107592, 2023. doi: 10.1016/j.clineuro.2023.107592 Epub 2023 Jan 13.
9. Masoud HE, de Havenon A, Castonguay AC, et al: 2022 Brief practice update on intravenous thrombolysis before thrombectomy in patients with large vessel occlusion acute ischemic stroke: A statement from Society of Vascular and Interventional Neurology Guidelines and Practice Standards (GAPS) Committee. Stroke. Vasc Interv Neurol 2 (4) 2022. doi: 10.1161/SVIN.121.000276
10. Zheng-Ming C, CAST (Chinese Acute Stroke Trial) Collaborative Group: CAST: Randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. Lancet 349 (9065):1641–1649, 1997.
11. Hao Q, Tampi M, O'Donnell M, et al: Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke or high risk transient ischaemic attack: Systematic review and meta-analysis. BMJ 363:k5108, 2018. doi: 10.1136/bmj.k5108
12. Alexander MJ, Zauner A, Chaloupka JC, et al: WEAVE Trial: Final results in 152 on-label patients. Stroke 50 (4):889–894, 2019. doi: 10.1161/STROKEAHA.118.023996
13. Powers WJ, Rabinstein AA, Ackerson T, et al:Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 50 (12):3331–3332, 2019. doi: 10.1161/STROKEAHA.119.027708 Epub 2019 Oct 30.
14. Kavinsky CJ, Szerlip M, Goldsweig AM, et al: SCAI guidelines for the management of patent foramen ovale. Standards and guidelines 1 (4), 100039, 2022. doi: 10.1016/j.jscai.2022.100039
Prognosis for Ischemic Stroke
Stroke severity and progression are often assessed using standardized measures such as the National Institutes of Health (NIH) Stroke Scale (see table ); the score on this scale correlates with extent of functional impairment and prognosis. During the first days, progression and outcome can be difficult to predict. Older age, impaired consciousness, aphasia, and brain stem signs suggest a poor prognosis. Early improvement and younger age suggest a favorable prognosis.
About 50% of patients with moderate or severe hemiplegia and most with milder deficits have a clear sensorium and eventually can take care of their basic needs and walk adequately. Complete neurologic recovery occurs in about 10%. Use of the affected limb is usually limited, and most deficits that remain after 12 months are permanent. Patients who have had a stroke are at high risk of subsequent strokes and each tends to worsen neurologic function. About 25% of patients who recover from a first stroke have another stroke within 5 years.
After an ischemic stroke, about 20% of patients die in the hospital; mortality rate increases with age.
Differentiate ischemic stroke from mimics (eg, postictal paralysis, hemiplegic migraine, CNS infections, functional neurologic disorders).
Although clinical differentiation is imprecise, some clues to help differentiate between common types of stroke include symptom progression (maximal deficits within minutes of onset with embolic versus sometimes stepwise or slow onset with thrombotic), time of onset (day with embolic versus night with thrombotic), and type of deficits (eg, specific syndromes and absence of cortical signs with lacunar infarcts).
Test patients for cardiac causes (including atrial fibrillation) and arterial stenosis (with vascular imaging), and do blood tests (eg, for thrombotic, rheumatic, and other disorders) as indicated.
In general, do not aggressively reduce BP soon after acute ischemic stroke.
To determine eligibility for tPA, use a checklist and, when available, consult an expert, either in person or via telemedicine.
To optimize the salvage of penumbral tissue, begin indicated thrombolytic therapy or mechanical thrombectomy as soon as possible ("time is brain").
To prevent future ischemic strokes, control modifiable risk factors and treat, when appropriate, with antiplatelet therapy, statin therapy, and/or endarterectomy or stenting.
Drugs Mentioned In This Article
|Drug Name||Select Trade|
|ATryn, Thrombate III|
|Cardene, Cardene IV, Cardene SR|
|Anacin Adult Low Strength, Aspergum, Aspir-Low, Aspirtab , Aspir-Trin , Bayer Advanced Aspirin, Bayer Aspirin, Bayer Aspirin Extra Strength, Bayer Aspirin Plus, Bayer Aspirin Regimen, Bayer Children's Aspirin, Bayer Extra Strength, Bayer Extra Strength Plus, Bayer Genuine Aspirin, Bayer Low Dose Aspirin Regimen, Bayer Womens Aspirin , BeneHealth Aspirin, Bufferin, Bufferin Extra Strength, Bufferin Low Dose, DURLAZA, Easprin , Ecotrin, Ecotrin Low Strength, Genacote, Halfprin, MiniPrin, St. Joseph Adult Low Strength, St. Joseph Aspirin, VAZALORE, Zero Order Release Aspirin, ZORprin|
|Activase, Cathflo Activase|
|Hepflush-10 , Hep-Lock, Hep-Lock U/P, Monoject Prefill Advanced Heparin Lock Flush, SASH Normal Saline and Heparin|
|Recothrom, Thrombi-Gel , Thrombin-JMI, Thrombin-JMI Epistaxis, Thrombi-Pad, Thrombogen|
|Xarelto, Xarelto Granules, Xarelto Starter Pack|