Merck Manual

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Chromium Deficiency

By

Larry E. Johnson

, MD, PhD, University of Arkansas for Medical Sciences

Reviewed/Revised Jul 2023
View PATIENT EDUCATION

Only 1 to 3% of biologically active trivalent chromium (Cr) is absorbed. Normal plasma levels are 0.05 to 0.50 mcg/L (1.0 to 9.6 nmol/L). However, it is not clear whether chromium should be considered an essential (required) trace element (1 Reference Only 1 to 3% of biologically active trivalent chromium (Cr) is absorbed. Normal plasma levels are 0.05 to 0.50 mcg/L (1.0 to 9.6 nmol/L). However, it is not clear whether chromium should be... read more ).

Chromium potentiates insulin activity; however, it is not known whether chromium picolinate supplementation is beneficial in diabetes mellitus Diabetes Mellitus (DM) Diabetes mellitus is impaired insulin secretion and variable degrees of peripheral insulin resistance leading to hyperglycemia. Early symptoms are related to hyperglycemia and include polydipsia... read more . Patients with diabetes should not take chromium supplements unless use is supervised by a diabetes specialist. Chromium supplements do not enhance muscle size or strength.

Patients receiving long-term total parenteral nutrition rarely develop chromium deficiency.

Symptoms of chromium deficiency may include weight loss, confusion, impaired coordination, and impaired glucose tolerance, increasing the risk of diabetes.

Treatment of chromium deficiency is with trivalent chromium.

Reference

  • 1. Vincent JB: New evidence against chromium as an essential trace element. J Nutr 147 (12):2212–2219, 2017. doi:10.3945/jn.117.255901

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