Merck Manual

Please confirm that you are a health care professional

honeypot link

Overview of Osteopetroses

(Marble Bones)


Frank Pessler

, MD, PhD, Hannover, Germany

Last full review/revision Oct 2020| Content last modified Oct 2020
Click here for Patient Education

Osteopetroses are familial disorders characterized by increased bone density and skeletal modeling abnormalities.

Osteopetroses can be categorized based on whether sclerosis or defective skeletal modeling predominates. There are a number of different types, including

They are all familial but have different inheritance patterns. Some types are comparatively benign; others are progressive and fatal.

Surgical decompression may be required to relieve elevated intracranial pressure or to release a trapped facial or auditory nerve.

Click here for Patient Education
NOTE: This is the Professional Version. CONSUMERS: Click here for the Consumer Version
Professionals also read

Test your knowledge

Neonatal Herpes Simplex Virus (HSV) Infection
Neonatal herpes simplex virus (HSV) infection has a high morbidity and mortality rate. The usual presenting symptom in neonates is a vesicular eruption that appears between the 1st and 3rd week of life. There are several ways in which this disease is transmitted to the neonate. Of these modes of transmission, which of the following is the most common? 
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID

Also of Interest