Pressure on a nerve for a long time is the most common cause of mononeuropathy.
The affected area may tingle, feel prickly, or be numb, and the affected muscle may be weak.
Usually, mononeuropathy is diagnosed based on symptoms and results of a physical examination.
Modifying or stopping the activity that caused the problem and taking pain relievers usually help, but sometimes corticosteroid injections, physical therapy, or surgery is needed.
(See also Overview of the Peripheral Nervous System Overview of the Peripheral Nervous System The peripheral nervous system refers to the parts of the nervous system that are outside the central nervous system, that is, those outside the brain and spinal cord. Thus, the peripheral nervous... read more .)
Physical injury is the most common cause of a mononeuropathy. Injury is commonly caused by pressure on a nerve, such as the following:
Prolonged pressure on a nerve that runs close to the surface of the body near a prominent bone, such as a nerve in an elbow, a shoulder, a wrist, or a knee (as may occur during a long, deep sleep, especially in alcoholics)
Pressure from a misfitting cast or from crutches that fit poorly or that are used incorrectly
Pressure from staying in a cramped position for a long time, as when gardening or when playing cards with the elbows resting on a table
Pressure may also injure nerves when people cannot move for long periods, as when they are under anesthesia for surgery, are confined to bed (particularly older people), are paralyzed, or have lost consciousness.
Less commonly, nerve injury results from the following:
Prolonged exposure to cold or heat
Radiation therapy for cancer
Repeated injuries, such as those due to tight gripping of small tools or to excessive vibration from an air hammer
Infections, such as leprosy Leprosy Leprosy is a chronic infection caused by the bacteria Mycobacterium leprae or Mycobacterium lepromatosis. It results in damage primarily to the peripheral nerves (the nerves outside the brain... read more or Lyme disease Lyme Disease Lyme disease is a tick-transmitted infection caused by Borrelia species, primarily by Borrelia burgdorferi and sometimes by Borrelia mayonii in the United States. These spiral-shaped bacteria... read more
A pocket of blood (hematoma)
Cancer, which may directly invade a nerve
If the pressure on the nerve is mild, people may feel only pins-and-needles sensations without any weakness. For example, people may hit their elbow (funny bone), or a foot may fall asleep. These episodes can be considered temporary mononeuropathies.
Nerves that run close to the body’s surface near a bone are more vulnerable to injury. For example, the following nerves may be damaged:
Ulnar nerve in the elbow (resulting in ulnar nerve palsy, usually cubital tunnel syndrome Cubital Tunnel Syndrome Cubital tunnel syndrome is a disorder caused by compression (pinching) of the ulnar nerve at the elbow. Repetitive use of the elbow can cause cubital tunnel syndrome. Symptoms include numbness... read more )
Mononeuropathies cause abnormal sensations, including pins-and-needles or loss of sensation, in the area supplied by the injured nerve. Pain and weakness may or may not be present. Occasionally, weakness results in paralysis, which can lead to permanent shortening and stiffening of muscles (contractures).
Carpal tunnel syndrome Carpal Tunnel Syndrome Carpal tunnel syndrome is a painful compression (pinching) of the median nerve as it passes through the carpal tunnel in the wrist. The cause of most cases of carpal tunnel syndrome is unknown... read more is the most common mononeuropathy. It results from pressure on the median nerve, which passes through a narrow passageway at the wrist (called the carpal tunnel).
Pregnant women and people who have diabetes Diabetes Mellitus (DM) Diabetes mellitus is a disorder in which the body does not produce enough or respond normally to insulin, causing blood sugar (glucose) levels to be abnormally high. Urination and thirst are... read more , an underactive thyroid gland (hypothyroidism Hypothyroidism Hypothyroidism is underactivity of the thyroid gland that leads to inadequate production of thyroid hormones and a slowing of vital body functions. Facial expressions become dull, the voice... read more ), certain forms of amyloidosis Amyloidosis read more , or rheumatoid arthritis Rheumatoid Arthritis (RA) Rheumatoid arthritis is an inflammatory arthritis in which joints, usually including those of the hands and feet, are inflamed, resulting in swelling, pain, and often destruction of joints.... read more are at increased risk of developing carpal tunnel syndrome. Also at risk are people whose work requires repeated forceful movements with the wrist extended, such as using a screwdriver. Another possible (but controversial) risk factor is use of a computer keyboard that is not positioned correctly. However, most cases develop for unknown reasons.
Pressure on the median nerve causes pain and abnormal sensations (such as numbness, tingling, or burning) in the following:
Chronic carpal tunnel syndrome can cause muscles in the hand on the thumb side to weaken and waste away (atrophy).
The peroneal nerve passes close to the surface of the skin just below the knee, on the outer side of the leg. Pressure on this nerve results in peroneal nerve palsy.
Peroneal nerve palsy weakens the muscles that lift the foot, so that people cannot flex their ankle to lift the front part of their foot (a condition called footdrop). As a result, they may drag the front part of the foot along the ground as they walk.
Peroneal nerve palsy is most common among thin people who are confined to bed, people who are incorrectly strapped into a wheelchair, and people (especially thin people) who habitually cross their legs for long periods of time.
Avoiding pressure on the nerve—for example, by not crossing the legs—usually relieves the symptoms.
The radial nerve passes along the underside of the bone in the upper arm. Prolonged pressure on this nerve results in radial nerve palsy Radial Tunnel Syndrome Radial tunnel syndrome is a disorder resulting from compression (pinching) of a branch of the radial nerve in the forearm or back of the arm or at the elbow. (See also Overview of Hand Disorders... read more . This disorder is sometimes called Saturday night palsy because it occurs in people who drink heavily (often during weekends) and then sleep soundly with an arm resting against a bar counter, draped over the back of a chair, or under their partner’s head. If crutches fit incorrectly and press on the inside of the arm near the armpit, they can cause this disorder.
The nerve damage weakens the wrist and fingers so that the wrist may flop into a bent position with the fingers curved (a condition called wristdrop). Occasionally, the back of the hand may lose feeling.
Usually, radial nerve palsy resolves once the pressure is relieved.
The ulnar nerve passes close to the surface of the skin at the elbow. The nerve is easily damaged by repeatedly leaning on the elbow or by hitting the elbow (funny bone). Sometimes the nerve is damaged by an abnormal bone growth in the area. The ulnar nerve, if damaged and swollen, may be squeezed (compressed) as it passes through a narrow passageway at the elbow (the cubital tunnel). The resulting disorder is called cubital tunnel syndrome Cubital Tunnel Syndrome Cubital tunnel syndrome is a disorder caused by compression (pinching) of the ulnar nerve at the elbow. Repetitive use of the elbow can cause cubital tunnel syndrome. Symptoms include numbness... read more . (The ulnar nerve passes through the cubital tunnel as it runs from the upper arm to the wrist and hand.)
Usually, people feel a tingling, pins-and-needles sensation in the little and ring fingers. Ulnar nerve palsy that results from more severe injury makes the muscles in the hand weak. Severe, chronic ulnar nerve palsy can cause muscles to waste away (atrophy), resulting in a clawhand deformity (the fingers are frozen in a bent position because the muscles become tight).
Avoiding pressure on the elbow is recommended.
Usually, doctors can diagnose mononeuropathies based on symptoms and results of a physical examination.
Electromyography and nerve conduction studies Electromyography and Nerve Conduction Studies Diagnostic procedures may be needed to confirm a diagnosis suggested by the medical history and neurologic examination. Electroencephalography (EEG) is a simple, painless procedure in which... read more are usually done to do the following:
If the cause of a mononeuropathy is a disorder, it is treated. For example, a tumor may be surgically removed.
Usually, when temporary pressure is the cause, the following can help relieve symptoms:
Some people with carpal tunnel syndrome benefit from corticosteroid Corticosteroids Rheumatoid arthritis is an inflammatory arthritis in which joints, usually including those of the hands and feet, are inflamed, resulting in swelling, pain, and often destruction of joints.... read more injections into the carpal tunnel.
Wrist splints, usually worn at night, are often used to treat carpal tunnel syndrome until the symptoms resolve. These devices reduce wrist movements, which cause inflammation and swelling in the carpal tunnel. Thus, the splints reduce pressure on the nerve, and symptoms of carpal tunnel syndrome lessen. Wrist splints should not be worn all day because when movement of the wrist is reduced for a long time, the wrist may become stiff and the muscles may waste away. Splints or braces are less helpful for cubital tunnel syndrome.
Surgery may be done to relieve pressure on a nerve if the disorder progresses despite other treatments. In such cases, surgery for carpal tunnel syndrome is usually effective.
For severe, chronic ulnar nerve palsy, physical therapy helps prevent tightening of muscles.
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