Merck Manual

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Wolf-Hirschhorn Syndrome

(4p Minus Syndrome)

By

Nina N. Powell-Hamilton

, MD, Sidney Kimmel Medical College at Thomas Jefferson University

Reviewed/Revised Nov 2023
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In Wolf-Hirschhorn syndrome, part of chromosome 4 is missing.

Children who survive into their 20s typically have severe disabilities. Many affected children die during infancy.

Symptoms of Wolf-Hirschhorn Syndrome

Some children have an immune deficiency, which means their body is less able to fight off infections.

Diagnosis of Wolf-Hirschhorn Syndrome

  • Chromosomal testing

The diagnosis of Wolf-Hirschhorn syndrome may be suspected by chromosomal testing before birth or by the child's physical characteristics after birth.

Treatment of Wolf-Hirschhorn Syndrome

  • Supportive care

Treatment of Wolf-Hirschhorn syndrome is supportive.

NOTE: This is the Consumer Version. DOCTORS: VIEW PROFESSIONAL VERSION
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