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Retinopathy of Prematurity (ROP)

By

Leila M. Khazaeni

, MD, Loma Linda University School of Medicine

Last full review/revision Jul 2020| Content last modified Jul 2020
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Retinopathy of prematurity is a disorder of premature infants in which the small blood vessels in the back of the eye (retina) grow abnormally.

  • Retinopathy of prematurity is strongly associated with premature birth, with most cases occurring in infants who are born before 30 weeks of development in the uterus.

  • In the most severe cases, the rapid abnormal growth of the small blood vessels can lead to detachment of the retina and loss of vision.

  • Because affected newborns have no symptoms, diagnosis depends on a careful examination by an eye specialist (ophthalmologist).

  • This disorder is usually mild and resolves without treatment, but the eyes need to be monitored by an ophthalmologist until blood vessel growth is mature.

  • If the disorder is severe, newborns require laser treatment, injections of bevacizumab, or surgery to prevent vision loss.

The blood vessels in the retina start growing in a fetus at about 18 to 20 weeks of development in the uterus and continue growing until the fetus is full term. When infants are born very prematurely, the blood vessels supplying the retina may stop growing for a time. When growth resumes, it occurs in a disorganized fashion. During disorganized rapid growth, the small blood vessels may bleed. In the most severe cases, this process may ultimately result in detachment of the retina from the back of the eye and severe loss of vision.

Viewing the Retina

Viewing the Retina

Premature infants are at increased risk of retinopathy of prematurity if they have serious disorders such as infections, bleeding in the brain, or lung disorders (such as bronchopulmonary dysplasia). Premature infants who receive oxygen for a long time (for example, because their lungs are immature) are also at increased risk.

Diagnosis

  • Eye examinations

Retinopathy of prematurity does not cause symptoms, so diagnosis depends on careful examination of the back of the eyes by an ophthalmologist (a medical doctor who specializes in the evaluation and treatment of all types of eye disorders). Routinely, therefore, an ophthalmologist examines the eyes of all premature newborns who weigh less than 3 pounds (about 1,500 grams) at birth or who were in the uterus for less then 30 weeks. Eye examinations are repeated every 1 to 3 weeks as needed, until growth of the blood vessels in the retina is complete.

Newborns with severe retinopathy must have eye examinations, at least yearly, for the rest of their life. If detected early, detachment of the retina can be treated with surgery in an attempt to avoid loss of vision in the affected eye.

Prognosis

Retinopathy of prematurity is usually mild and resolves spontaneously. However, in about 20 to 40% of affected infants weighing less than 2.2 pounds (about 1 kilogram) at birth, the disorder is severe and in about 4% progresses to cause detachment of the retina and vision loss within 2 to 12 months after delivery.

Children whose retinopathy of prematurity has healed are at greater risk of developing other eye problems such as nearsightedness (myopia), strabismus, and amblyopia. A few children with moderate, healed retinopathy of prematurity are left with scars on the retina and are at risk of detachment of the retina later in life. Rarely, glaucoma and cataracts can also occur.

Prevention

When premature newborns need oxygen, oxygen levels are monitored carefully so that the lowest amount of oxygen necessary can be used. Oxygen levels can be indirectly monitored using a pulse oximeter (an external sensor that measures the level of oxygen in the blood going through a finger or toe).

Treatment

  • Laser photocoagulation

  • Bevacizumab

  • Sometimes surgery

For very severe retinopathy of prematurity, laser photocoagulation treatment is done on the outermost portions of the retina. In this treatment, a laser beam is used to stop the abnormal growth of blood vessels and decrease the risk of detachment of the retina and loss of vision.

A drug called bevacizumab may also be injected to stop the abnormal growth of blood vessels in the retina.

If retinopathy of prematurity leads to a partial or complete detachment of the retina, sometimes surgery is done to reattach the retina and prevent further vision loss.

More Information

The following is an English-language resource that may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

Drugs Mentioned In This Article

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AVASTIN
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