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Gastrinoma

(Zollinger-Ellison Syndrome; Z-E Syndrome)

By

Minhhuyen Nguyen

, MD, Fox Chase Cancer Center, Temple University

Last full review/revision Mar 2021| Content last modified Mar 2021
Click here for the Professional Version
Topic Resources
  • These tumors arise from cells in the pancreas that produce gastrin.

  • Symptoms are similar to those caused by peptic ulcers, including pain and bleeding.

  • Diagnosis includes blood and imaging tests.

  • The survival rate is high if the tumor is completely removed.

  • Treatment includes drugs to reduce acid in the stomach and sometimes surgery and chemotherapy.

Symptoms of Gastrinoma

The excess gastrin secreted by the gastrinoma causes the stomach to produce far too much acid. This overproduction of acid can results in Zollinger-Ellison syndrome. In Zollinger-Ellison syndrome, a person has symptoms of aggressive peptic ulcers Peptic Ulcer Disease A peptic ulcer is a round or oval sore where the lining of the stomach or duodenum has been eaten away by stomach acid and digestive juices. Peptic ulcers can result from Helicobacter pylori... read more Peptic Ulcer Disease (such as pain or bleeding) in the stomach, duodenum, and elsewhere in the intestine. However, as many as 25% of people with Zollinger-Ellison syndrome may not have an ulcer when the diagnosis is made. Rupture, bleeding, and obstruction of the intestine can occur and can be life threatening. For more than half of the people with a gastrinoma, symptoms are no worse than those experienced by people with ordinary peptic ulcer disease. In 25 to 40% of people, diarrhea resulting from the excess acid production is the first symptom.

Diagnosis of Gastrinoma

  • Blood tests

  • Imaging tests

A doctor suspects a gastrinoma when a person has frequent peptic ulcers or several peptic ulcers that do not respond to the usual ulcer treatments. Blood tests to detect abnormally high levels of gastrin are the most reliable diagnostic tests.

Prognosis of Gastrinoma

If the tumor is completely surgically removed, people have a greater than 90% chance of surviving 5 to 10 years. If the tumor is not completely removed, people have a 43% chance of surviving 5 years and a 25% chance of surviving 10 years.

Treatment of Gastrinoma

  • Methods to reduce levels of stomach acid

  • Sometimes surgical removal

  • Sometimes chemotherapy

High doses of proton pump inhibitors, which are acid-reducing drugs Drug Treatment of Stomach Acid Stomach acid plays a role in a number of disorders of the stomach, including peptic ulcer, gastritis, and gastroesophageal reflux disease (GERD). Although the amount of acid present in the stomach... read more (see Table: Drug Treatment of Stomach Acid Drug Treatment of Stomach Acid Stomach acid plays a role in a number of disorders of the stomach, including peptic ulcer, gastritis, and gastroesophageal reflux disease (GERD). Although the amount of acid present in the stomach... read more ) may be effective for reducing acid levels and relieving symptoms temporarily. If these drugs are not effective enough, injections of octreotide may help. If there is only one tumor and the person does not have multiple endocrine neoplasia, doctors usually do surgery to remove the gastrinoma. In such cases, surgical removal cures about 20% of people.

If these treatments do not work, an operation to remove the stomach completely (total gastrectomy) may be necessary. This operation does not remove the tumor, but the gastrin can no longer create ulcers after the acid-producing stomach is removed. If the stomach is removed, daily iron and calcium supplements taken by mouth and monthly injections of vitamin B12 are needed, because absorption of these nutrients is impaired when stomach juices that prepare these nutrients for absorption are no longer available.

If cancerous tumors have spread to other parts of the body, chemotherapy may help reduce the number of tumor cells and the levels of gastrin in the blood. However, such therapy does not cure the cancer, which is ultimately fatal.

Drugs Mentioned In This Article

Generic Name Select Brand Names
SANDOSTATIN
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