(Gilchrist Disease; North American Blastomycosis)
People have a fever, chills, and drenching sweats and sometimes chest pain, difficulty breathing, and a cough.
The infection may spread to the skin, bones, reproductive and urinary tracts, and tissues covering the brain, causing swelling, pain, and other symptoms.
A sample of infected sputum or tissues is removed and sent for culture, and a chest x-ray is taken.
Antifungal drugs must be taken for months.
(See also Overview of Fungal Infections.)
Spores of Blastomyces enter the body through the airways when the spores are inhaled. Thus, blastomycosis affects primarily the lungs, but the fungi occasionally spread through the bloodstream to other areas of the body, most commonly the skin.
Blastomycosis may be more common among and more severe in some people with a weakened immune system. Unlike most fungal infections, blastomycosis is not more common among people with AIDS. However, it tends to be more severe in people with AIDS.
Most cases of blastomycosis occur in areas of North America where the fungus lives in the soil near river beds:
Rarely, the infection occurs in the Middle East and Africa.
Sometimes blastomycosis of the lungs causes no symptoms or causes symptoms that disappear quickly and are not recognized.
When symptoms do occur, they can begin abruptly or gradually. They include a fever, chills, and drenching sweats. Chest pain, difficulty breathing, and a hacking cough that may or may not bring up sputum may also develop. The lung infection usually progresses slowly, but people sometimes get better without treatment. In some people, infection progresses rapidly.
When blastomycosis spreads, it can affect many areas of the body, but the most common sites are the following:
Skin infection begins as very small, raised bumps (papules), which may contain pus. Raised, warty patches then develop, surrounded by tiny, painless collections of pus (abscesses).
Tissues over infected bones may become swollen, warm, and painful.
In men, the coiled tube on top of testes (epididymis) may swell, causing pain, or infection of the prostate gland (prostatitis) may cause discomfort.
Fungi can spread to the tissues that cover the brain and spinal cord (meninges), causing fungal meningitis. Abscesses may develop in the brain. This infection can cause headache and confusion.
A doctor diagnoses blastomycosis by sending a sample of sputum or infected tissue to a laboratory to be examined under a microscope and cultured. A chest x-ray is taken to check for signs of infection in the lungs.
Doctors may also test a urine sample for proteins (antigens) released by the fungus.
Tests that detect genetic material in microorganisms, such as polymerase chain reaction (PCR), may be done. The PCR test is used to produce many copies of a gene from a microorganism, making the microorganism much easier to identify.
Blastomycosis, if severe, is treated with amphotericin B, given intravenously. If blastomycosis is mild to moderate, itraconazole is given by mouth.
With treatment, people begin to feel better fairly quickly, but the drugs must be continued for 6 to 12 months. Without treatment, blastomycosis slowly worsens and, rarely, leads to death.
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