Liver tests are blood tests that represent a noninvasive way to screen for the presence of liver disease (for example, hepatitis Overview of Hepatitis Hepatitis is inflammation of the liver. (See also Overview of Acute Viral Hepatitis and Overview of Chronic Hepatitis.) Hepatitis is common throughout the world. Hepatitis can be Acute (short-lived) read more in donated blood) and to measure the severity and progress of liver disease as well as the response to treatment.
Laboratory tests are generally effective for the following:
Detecting liver inflammation, damage, or dysfunction
Monitoring the course of liver diseases and a person's response to treatment
Refining the diagnosis
Liver tests are done on blood samples and measure the levels of enzymes and other substances produced by the liver. These substances include
Alanine aminotransferase (ALT)
Alkaline phosphatase (ALP)
Aspartate aminotransferase (AST)
Gamma-glutamyl transpeptidase (GGT)
Lactate dehydrogenase (LDH)
Levels of some of these substances measure the presence and degree of liver inflammation (for example, ALT, AST). Levels of other substances measure how well the liver performs its normal functions of making proteins and secreting bile (for example, albumin, bilirubin). What constitutes a normal value for many of these tests can be found in the table Blood Tests Blood Tests* . However, some of these values can be higher than normal in people with disorders not related to the liver.
One test of liver function is the prothrombin time (PT), which is used to calculate the international normalized ratio (INR). Both the PT and the INR are measures of the time needed for blood to clot (the liver synthesizes some proteins necessary for blood clotting, called blood clotting factors). An abnormal PT or INR result can indicate an acute or chronic liver disorder. In both acute and chronic liver disorders, an increasing PT or INR typically indicates progression to liver failure Liver Failure Liver failure is severe deterioration in liver function. Liver failure is caused by a disorder or substance that damages the liver. Most people have jaundice (yellow skin and eyes), feel tired... read more .
The following are some English-language resources that may be useful. Please note that THE MANUAL is not responsible for the content of these resources.
American Liver Foundation, Diagnosing Liver Disease—Liver Biopsy and Liver Function Tests: General information on how liver biopsy and liver function tests are used to check the health of the liver and detect liver damage and disease.
Lab Tests Online: A variety of laboratory tests used to screen for and diagnose disorders.