Merck Manual

Please confirm that you are not located inside the Russian Federation

honeypot link

Atypical Fibroxanthoma


Gregory L. Wells

, MD, Idaho College of Osteopathic Medicine

Last full review/revision Jan 2021| Content last modified Jan 2021
Click here for the Professional Version

Atypical fibroxanthoma is a skin sarcoma (a type of cancer) that tends to grow slowly.

Atypical fibroxanthomas are uncommon but usually occur on the head and neck of older people. They may look like other skin cancers (other than melanoma) and often appear as pink-red raised areas or bumps that do not heal and may be tender.

Diagnosis of Atypical Fibroxanthoma

  • Biopsy

Doctors base the diagnosis of atypical fibroxanthoma on the results of a biopsy. During this procedure, a small piece of the tumor is removed and examined under a microscope.

Prevention of Atypical Fibroxanthoma

Because atypical fibroxanthoma cancers seem to be related to exposure to ultraviolet (UV) light (see Overview of Sunlight and Skin Damage), doctors recommend a number of measures to limit UV exposure, starting in early childhood.

  • Avoiding the sun: For example, seeking shade, minimizing outdoor activities between 10 AM and 4 PM (when the sun’s rays are strongest), and avoiding sunbathing and the use of tanning beds

  • Wearing protective clothing: For example, long-sleeved shirts, pants, and broad-brimmed hats

  • Using sunscreen: At least sun protection factor (SPF) 30 with UVA and UVB protection used as directed and reapplied every 2 hours and after swimming or sweating but not used to prolong sun exposure

Treatment of Atypical Fibroxanthoma

  • Removal of the tumor

Atypical fibroxanthomas do not typically spread (metastasize) to other organs. Tumors are surgically removed, or Mohs microscopically controlled surgery is done.

NOTE: This is the Consumer Version. DOCTORS: Click here for the Professional Version
Click here for the Professional Version
Others also read

Test your knowledge

Dermatitis Herpetiformis
Dermatitis herpetiformis is an autoimmune disease that causes clusters of intensely itchy small blisters and hive-like swellings on the skin of people who have celiac disease. Which of the following foods can trigger an attack of dermatitis herpetiformis? 
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID

Also of Interest

Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID