honeypot link

Merck Manual

Please confirm that you are not located inside the Russian Federation



Laura Shane-McWhorter

, PharmD, University of Utah College of Pharmacy

Last full review/revision Jul 2020| Content last modified Jul 2020
Click here for the Professional Version

Creatine is an amino acid made in the liver and stored in muscles. When combined with phosphate, it is a readily available source of energy in the body. In the diet, creatine is found in milk, red meat, and some fish.

Medicinal claims

People take supplements of creatine to improve physical or athletic performance and to decrease muscle fatigue. Some studies indicate that creatine can increase the amount of work performed with a short maximal effort (for example, in sprinting).

Possible side effects

Creatine supplements may cause weight gain and may elevate levels of creatine in the urine and blood and cause kidney dysfunction. Minor stomach upset, dehydration, and muscle cramps occur occasionally. People who have a history of kidney dysfunction should avoid creatine supplements.

More Information

The following is an English-language resource that may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

NOTE: This is the Consumer Version. DOCTORS: Click here for the Professional Version
Click here for the Professional Version
Others also read

Also of Interest


iOS Android
iOS Android
iOS Android