Merck Manual

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Pelvic Inflammatory Disease (PID)


Oluwatosin Goje

, MD, MSCR, Cleveland Clinic, Lerner College of Medicine of Case Western Reserve University

Last full review/revision Sep 2019| Content last modified Sep 2019
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Pelvic inflammatory disease is an infection of the upper female reproductive organs (the cervix, uterus, fallopian tubes, and ovaries).

  • Pelvic inflammatory disease is usually transmitted during sexual intercourse with an infected partner.

  • Typically, women have pain in the lower abdomen, a vaginal discharge, and irregular vaginal bleeding.

  • The diagnosis is based on symptoms, analysis of secretions from the cervix and vagina, and sometimes ultrasonography.

  • Having sexual intercourse with only one partner and using condoms reduce the risk of infection.

  • Antibiotics can eliminate the infection.

Pelvic inflammatory disease may be an infection of

  • The cervix, which is the lower, narrow part of the uterus that opens into the vagina (cervicitis)

  • The lining of the uterus (endometritis)

  • The fallopian tubes (salpingitis)

  • A combination of the above

If the infection is severe, it can

  • Spread to the ovaries (oophoritis)

  • Produce a collection of pus in the fallopian tubes (tubo-ovarian abscess)

Pelvic inflammatory disease is the most common preventable cause of infertility in the United States. Infertility occurs in about one of five women with pelvic inflammatory disease.

About one third of women who have had pelvic inflammatory disease develop the infection again.

Pelvic inflammatory disease usually occurs in sexually active women. It rarely affects girls before their first menstrual period (menarche) or women during pregnancy or after menopause. Risk is increased for the following women:

  • Those who are sexually active and younger than 35

  • Those whose partner does not use a condom

  • Those who have many or new sex partners

  • Those who have had pelvic inflammatory disease before

  • Those of lower socioeconomic status (who usually have less access to health care)


Pelvic inflammatory disease is usually caused by bacteria from the vagina. Most commonly, the bacteria are transmitted during sexual intercourse with a partner who has a sexually transmitted disease. The most common sexually transmitted bacteria are

These bacteria typically spread from the vagina to the cervix (the lower part of the uterus that opens into the vagina), where they cause infection (cervicitis). These infections may remain in the cervix or spread upward, causing pelvic inflammatory disease.

Pelvic inflammatory disease also commonly occurs in women who have bacterial vaginosis. The bacteria that cause bacterial vaginosis normally reside in the vagina. They cause symptoms and spread to other organs only if they increase in number (overgrow). Whether bacterial vaginosis is sexually transmitted is unknown.

Less commonly, women are infected during a vaginal delivery, an abortion, or a medical procedure, such as dilation and curettage (D and C) or gynecologic surgery—when bacteria are introduced into the vagina or when bacteria that normally reside in the vagina are moved into the uterus.

Douching increases the risk of infection.

Did You Know...

  • The most common preventable cause of infertility is pelvic inflammatory disease.


Symptoms of pelvic inflammatory disease commonly occur toward the end of the menstrual period or during the few days after it. For many women, the first symptom is mild to moderate pain (often aching) in the lower abdomen, which may be worse on one side. Other symptoms include irregular vaginal bleeding and a vaginal discharge, sometimes with a bad odor.

As the infection spreads, pain in the lower abdomen becomes increasingly severe and may be accompanied by a low-grade fever (usually below 102° F [38.9° C]) and nausea or vomiting. Later, the fever may become higher, and the discharge often becomes puslike and yellow-green. Women may have pain during sexual intercourse or urination.

The infection may be severe but cause mild or no symptoms. Symptoms due to gonorrhea tend to be more severe than those of a chlamydial infection or infection due to Mycoplasma genitalium, which may not cause a discharge or any other noticeable symptoms.


Pelvic inflammatory disease can cause other problems, including the following:

  • Blocked fallopian tubes

  • Peritonitis (a serious abdominal infection)

  • Fitz-Hugh-Curtis syndrome (a serious infection of tissues around the liver)

  • An abscess (a collection of pus)

  • Adhesions (bands of scar tissue)

  • A pregnancy in a fallopian tube (tubal pregnancy)

Sometimes infected fallopian tubes become blocked. Blocked tubes may swell because fluid is trapped. Women may feel pressure or have chronic pain in the lower abdomen.

Peritonitis develops if the infection spreads to the membrane that lines the abdominal cavity and covers the abdominal organs. Peritonitis can cause sudden or gradual severe pain in the entire abdomen.

The Fitz-Hugh-Curtis syndrome develops if infection of the fallopian tubes is due to gonorrhea or a chlamydial infection and it spreads to the tissues around the liver. Such an infection may cause pain in the upper right side of the abdomen. The pain resembles that of a gallbladder disorder or gallstones.

An abscess forms in the fallopian tubes or ovaries of about 15% of women who have infected fallopian tubes, particularly if they have had the infection a long time. An abscess sometimes ruptures, and pus spills into the pelvic cavity (causing peritonitis). A rupture causes severe pain in the lower abdomen, quickly followed by nausea, vomiting, and very low blood pressure (shock). The infection may spread to the bloodstream (a condition called sepsis) and can be fatal. It is a medical emergency.

Adhesions are abnormal bands of scar tissue. They can develop when pelvic inflammatory disease produces a puslike fluid. This fluid irritates tissues and causes bands of scar tissue to form in the reproductive organs or between organs in the abdomen. Infertility and chronic pelvic pain may result. The longer and more severe the inflammation and the more often it recurs, the higher the risk of infertility and other complications. The risk increases each time a woman develops the infection.

A tubal pregnancy (a type of ectopic pregnancy) is 6 to 10 times more likely to occur in women who have had pelvic inflammatory disease. In a tubal pregnancy, the fetus grows in a fallopian tube rather than in the uterus. This type of pregnancy threatens the life of the woman, and the fetus cannot survive.


  • A doctor's evaluation

  • Tests on a sample taken from the cervix

  • A pregnancy test

  • Sometimes ultrasonography or laparoscopy

Doctors suspect pelvic inflammatory disease if women have pain in the lower abdomen or if they have an unexplained discharge from the vagina, particularly if they are of childbearing age. A physical examination, including a pelvic examination, is done. Pain felt in the pelvic area during the pelvic examination supports the diagnosis.

A sample is usually taken from the cervix with a swab and tested to determine whether the woman has gonorrhea or a chlamydial infection. Even if these tests do not detect gonorrhea or a chlamydial infection, women may still have pelvic inflammatory disease.

A pregnancy test is done to see whether the woman may have a tubal pregnancy, which could be the cause of the symptoms. Other symptoms and laboratory test results help confirm the diagnosis.

Ultrasonography of the pelvis is done if pain prevents an adequate physical examination or if more information is needed. It can detect abscesses in the fallopian tubes or ovaries and a tubal pregnancy.

If the diagnosis is still uncertain or if the woman does not respond to treatment, the doctor may insert a viewing tube (laparoscope) through a small incision near the navel to view the inside of the abdomen and to obtain a sample of fluids for testing. This procedure can usually confirm or rule out pelvic inflammatory disease.


Prevention of pelvic inflammatory disease is essential to the health and fertility of a woman.

Abstaining from sex is a foolproof way to avoid sexually transmitted pelvic inflammatory disease. However, if a woman has sexual intercourse with only one partner, the risk of pelvic inflammatory disease is very low, as long as neither person is infected with the bacteria that cause sexually transmitted diseases.

If used correctly, condoms can help prevent pelvic inflammatory disease. To be effective, condoms must be used correctly each time a person has sex.


  • Antibiotics

  • If needed, drainage of an abscess

As soon as possible, antibiotics for gonorrhea and chlamydial infection are usually given by mouth or by injection into a muscle. If needed, the antibiotics are changed after test results are available.

Most women are treated at home with antibiotics taken by mouth. However, hospitalization is usually necessary in the following situations:

  • The infection does not lessen within 72 hours.

  • The woman has severe symptoms or a high fever.

  • The woman may be pregnant.

  • An abscess is suspected.

  • The woman is vomiting and thus cannot take antibiotics by mouth at home.

  • Doctors cannot confirm the diagnosis of pelvic inflammatory disease and cannot rule out disorders that require surgery (such as appendicitis) as possible causes.

In the hospital, antibiotics are given intravenously.

Abscesses that persist despite treatment with antibiotics may be drained. Often, a needle can be used. It is inserted through a small incision in the skin, and an imaging test, such as ultrasonography or computed tomography (CT), is used to guide the needle into the abscess. A ruptured abscess requires emergency surgery.

Women should refrain from sexual intercourse until antibiotic therapy is completed and a doctor confirms that the infection is completely eliminated, even if symptoms disappear.

All recent sex partners should be tested for gonorrhea and chlamydial infection and, if needed, treated. If pelvic inflammatory disease is diagnosed and treated promptly, a full recovery is more likely.

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