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Ventricular Tachycardia (VT)

By

L. Brent Mitchell

, MD, Libin Cardiovascular Institute of Alberta, University of Calgary

Last review/revision Jan 2023
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Ventricular tachycardia is 3 consecutive ventricular beats at a rate 120 beats/minute. Symptoms depend on duration and vary from none to palpitations to hemodynamic collapse and death. Diagnosis is by electrocardiography. Treatment of more than brief episodes is with cardioversion or antiarrhythmics, depending on symptoms. If necessary, long-term treatment is with an implantable cardioverter defibrillator.

Some experts use a cutoff rate of 100 beats/minute for ventricular tachycardia (VT). Repetitive ventricular rhythms at slower rates are called accelerated idioventricular rhythms or slow VT; they are usually benign and are not treated unless patients have hemodynamic symptoms.

Most patients with VT have a significant heart disorder, particularly prior myocardial infarction Acute Myocardial Infarction (MI) Acute myocardial infarction is myocardial necrosis resulting from acute obstruction of a coronary artery. Symptoms include chest discomfort with or without dyspnea, nausea, and/or diaphoresis... read more Acute Myocardial Infarction (MI) or a cardiomyopathy Overview of Cardiomyopathies A cardiomyopathy is a primary disorder of the heart muscle. It is distinct from structural cardiac disorders such as coronary artery disease, valvular disorders, and congenital heart disorders... read more . Electrolyte abnormalities (particularly hypokalemia Hypokalemia Hypokalemia is serum potassium concentration < 3.5 mEq/L (< 3.5 mmol/L) caused by a deficit in total body potassium stores or abnormal movement of potassium into cells. The most common... read more or hypomagnesemia Hypomagnesemia Hypomagnesemia is serum magnesium concentration < 1.8 mg/dL (< 0.70 mmol/L). Causes include inadequate magnesium intake and absorption or increased excretion due to hypercalcemia or drugs... read more ), acidemia, hypoxemia, and adverse drug effects contribute. The long QT syndrome Long QT Interval Syndromes The long QT interval syndromes (LQTS) result from any congenital or acquired disorder of cardiac ion channel function or regulation (channelopathy) that prolongs ventricular myocyte action potential... read more (congenital or acquired) is associated with a particular form of VT, torsades de pointes Torsades de Pointes Ventricular Tachycardia Torsades de pointes ventricular tachycardia is a specific form of polymorphic ventricular tachycardia in patients with a long QT interval. It is characterized by rapid, irregular QRS complexes... read more .

Ventricular tachycardia may be monomorphic or polymorphic and nonsustained or sustained.

  • Monomorphic VT: Single abnormal focus or reentrant pathway and thus regular, identical-appearing QRS complexes

  • Polymorphic VT: Several different foci or pathways and thus irregular, varying QRS complexes

  • Nonsustained VT: Lasts < 30 seconds

  • Sustained VT: Lasts 30 seconds or is terminated sooner because of hemodynamic collapse

Catecholaminergic polymorphic ventricular tachycardia Catecholaminergic Polymorphic Ventricular Tachycardia Catecholaminergic polymorphic ventricular tachycardia is a genetic disorder affecting intracellular calcium regulation in cardiac tissue. Patients are predisposed to ventricular tachyarrhythmias... read more is a genetic disorder affecting intracellular calcium regulation in cardiac tissue. Patients are predisposed to atrial and/or ventricular tachyarrhythmias and sudden cardiac death, particularly during increased adrenergic activity.

Symptoms and Signs of Ventricular Tachycardia

Ventricular tachycardia of short duration or slow rate may be asymptomatic. Sustained VT is almost always symptomatic, causing palpitations, symptoms of hemodynamic compromise, or sudden cardiac death.

Diagnosis of Ventricular Tachycardia

  • Electrocardiography (ECG)

Diagnosis of ventricular tachycardia is by ECG (see figure Broad QRS ventricular tachycardia Broad QRS ventricular tachycardia Broad QRS ventricular tachycardia ). Any wide QRS complex tachycardia (QRS 0.12 second) should be considered VT until proved otherwise.

Pearls & Pitfalls

  • Any wide QRS complex tachycardia (QRS 0.12 second) should be considered VT until proved otherwise.

Diagnosis is supported by ECG findings of dissociated P-wave activity, fusion or capture beats, uniformity of QRS vectors in the V leads (concordance) with discordant T-wave vector (opposite QRS vectors), and a frontal-plane QRS axis in the northwest quadrant. Differential diagnosis includes supraventricular tachycardia Reentrant Supraventricular Tachycardias (SVT) Including Wolff-Parkinson-White Syndrome Reentrant supraventricular tachycardias (SVT) involve reentrant pathways with a component above the bifurcation of the His bundle. Patients have sudden episodes of palpitations that begin and... read more conducted with bundle branch block or via an accessory pathway (see figure ). However, because some patients tolerate VT surprisingly well, concluding that a well-tolerated wide QRS complex tachycardia must be of supraventricular origin is a mistake. Using medications appropriate for supraventricular tachycardia (eg, verapamil, diltiazem) in patients with VT may cause hemodynamic collapse and death.

Pearls & Pitfalls

  • Because some patients tolerate ventricular tachycardia surprisingly well, it is a mistake to conclude that a well-tolerated wide QRS complex tachycardia must be of supraventricular origin.

Broad QRS ventricular tachycardia

The QRS duration is 160 millisecond. An independent P wave can be seen in II (arrows). There is a leftward mean frontal axis shift.

Broad QRS ventricular tachycardia

Treatment of Ventricular Tachycardia

  • Acute: Sometimes synchronized direct current cardioversion, sometimes class I or class III antiarrhythmics

  • Long-term: Usually an implantable cardioverter-defibrillator

Acute

Treatment of acute ventricular tachycardia depends on symptoms and duration of VT.

Stable sustained VT can also be treated with intravenous class I or class III antiarrhythmic drugs (see table ). Lidocaine acts quickly but is frequently ineffective. If lidocaine is ineffective, IV procainamide may be given, but it may take up to 1 hour to work. IV amiodarone is frequently used but does not usually work quickly. Failure of IV procainamide or IV amiodarone is an indication for cardioversion.

Nonsustained VT does not require immediate treatment unless the runs are frequent or long enough to cause symptoms. In such cases, antiarrhythmics are used as for sustained VT.

Long-term

The primary goal is preventing sudden death, rather than simply suppressing the arrhythmia. It is best accomplished by use of an implantable cardioverter-defibrillator Implantable Cardioverter-Defibrillators (ICD) The need for treatment of arrhythmias depends on the symptoms and the seriousness of the arrhythmia. Treatment is directed at causes. If necessary, direct antiarrhythmic therapy, including antiarrhythmic... read more Implantable Cardioverter-Defibrillators (ICD) (ICD). However, the decision about whom to treat is complex and depends on the estimated probability of life-threatening VTs and the severity of underlying heart disorders (see table ).

Long-term treatment is not required when the index episode of ventricular tachycardia resulted from a transient cause (eg, during the 48 hours after onset of myocardial infarction) or a reversible cause (acid-base disturbances, electrolyte abnormalities, proarrhythmic drug effect).

In the absence of a transient or reversible cause, patients who have had an episode of sustained VT typically require an ICD. Most patients with sustained VT and a significant structural heart disorder should also receive a beta-blocker. If an ICD cannot be used, amiodarone may be the preferred antiarrhythmic for prevention of sudden death.

Because nonsustained VT is a marker for increased risk of sudden death in patients with a structural heart disorder, such patients (particularly those with an ejection fraction < 0.35) require further evaluation. Such patients should receive an ICD.

When prevention of VTs is important (usually in patients who have an ICD and are having frequent episodes of VT), antiarrhythmics or transcatheter or surgical ablation Ablation for Cardiac Arrhythmia The need for treatment of arrhythmias depends on the symptoms and the seriousness of the arrhythmia. Treatment is directed at causes. If necessary, direct antiarrhythmic therapy, including antiarrhythmic... read more of the arrhythmogenic substrate is required. Any class Ia, Ib, Ic, II, or III antiarrhythmic drug Medications for Arrhythmias The need for treatment of arrhythmias depends on the symptoms and the seriousness of the arrhythmia. Treatment is directed at causes. If necessary, direct antiarrhythmic therapy, including antiarrhythmic... read more can be used. Because beta-blockers are safe, they are the first choice unless contraindicated. If an additional drug is required, sotalol is commonly used, then amiodarone.

Transcatheter ablation Ablation for Cardiac Arrhythmia The need for treatment of arrhythmias depends on the symptoms and the seriousness of the arrhythmia. Treatment is directed at causes. If necessary, direct antiarrhythmic therapy, including antiarrhythmic... read more is used most commonly in patients who have VT with well-defined syndromes (eg, right ventricular outflow tract VT or left septal VT [Belhassen VT, verapamil-sensitive VT]) and otherwise healthy hearts.

Overview of Ventricular Tachycardia
VIDEO

Key Points

  • Any wide-complex (QRS ≥ 0.12 second) tachycardia should be considered ventricular tachycardia (VT) until proved otherwise.

  • Patients who do not have a pulse should be cardioverted.

  • Synchronized cardioversion or antiarrhythmic drugs may be tried if the patient is stable.

  • Patients who had an episode of sustained VT without a transient or reversible cause typically require an implantable cardioverter-defibrillator (ICD).

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