Merck Manual

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Purulent Labyrinthitis


Lawrence R. Lustig

, MD, Columbia University Medical Center and New York Presbyterian Hospital

Last full review/revision Apr 2020| Content last modified Apr 2020
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Purulent (suppurative) labyrinthitis is bacterial infection of the inner ear, often causing deafness and loss of vestibular function.

Purulent labyrinthitis usually occurs when bacteria spread to the inner ear during the course of severe acute otitis media, purulent meningitis, trauma causing a labyrinthine fracture with a subsequent infection, or an enlarging cholesteatoma.

Symptoms and Signs

Symptoms of purulent labyrinthitis include

  • Severe vertigo and nystagmus

  • Nausea and vomiting

  • Tinnitus

  • Varying degrees of hearing loss

Pain and fever are common.


  • Temporal bone CT

  • Possibly MRI

Purulent labyrinthitis is suspected if vertigo, nystagmus, sensorineural hearing loss, or a combination occurs during an episode of acute otitis media. CT of the temporal bone is done to identify erosion of the otic capsule bone or other complications of acute otitis media, such as coalescent mastoiditis. MRI may be indicated if symptoms of meningitis or brain abscess, such as altered mental status, meningismus, or high fever, are present; in such cases, a lumbar puncture and blood cultures also are done.


  • IV antibiotics

  • Myringotomy

  • Sometimes tympanostomy

Treatment of purulent labyrinthitis is with IV antibiotics appropriate for meningitis (eg, ceftriaxone 50 to 100 mg/kg IV once/day to maximum 2 g). Ceftazidime is often substituted for ceftriaxone in nosocomial infections to cover P. aeruginosa. The antibiotics are later adjusted according to results of culture and sensitivity testing. A myringotomy (and sometimes tympanostomy tube placement) is done to drain the middle ear. Mastoidectomy may be required.

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