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Erosive Gastritis

By

Nimish Vakil

, MD, University of Wisconsin School of Medicine and Public Health

Last full review/revision Jun 2021| Content last modified Jun 2021
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Erosive gastritis is gastric mucosal erosion caused by damage to mucosal defenses. It is typically acute, manifesting with bleeding, but may be subacute or chronic with few or no symptoms. Diagnosis is by endoscopy. Treatment is supportive, with removal of the inciting cause and initiation of acid-suppressant therapy. Certain intensive care unit patients (eg, ventilator-bound, head trauma, burn, multisystem trauma) benefit from prophylaxis with acid suppressants.

Common causes of erosive gastritis include

  • Nonsteroidal anti-inflammatory drugs (NSAIDs)

  • Alcohol

  • Stress

Less common causes include

Superficial erosions and punctate mucosal lesions occur. These may develop as soon as 12 hours after the initial insult. Deep erosions, ulcers, and sometimes perforation may occur in severe or untreated cases. Lesions typically occur in the body, but the antrum may also be involved.

Acute stress gastritis, a form of erosive gastritis, occurs in about 5% of critically ill patients. The incidence increases with duration of intensive care unit stay and length of time the patient is not receiving enteral feeding. Pathogenesis likely involves hypoperfusion of the gastrointestinal mucosa, resulting in impaired mucosal defenses. Patients with head injury or burns may also have increased secretion of acid.

Symptoms and Signs of Erosive Gastritis

Patients with mild erosive gastritis are often asymptomatic, although some complain of dyspepsia, nausea, or vomiting. Often, the first sign is hematemesis, melena, or blood in the nasogastric aspirate, usually within 2 to 5 days of the inciting event. Bleeding is usually mild to moderate, although it can be massive if deep ulceration is present, particularly in acute stress gastritis.

Diagnosis of Erosive Gastritis

  • Endoscopy

Acute and chronic erosive gastritis are diagnosed endoscopically.

Treatment of Erosive Gastritis

  • For bleeding: Endoscopic hemostasis

  • For acid suppression: A proton pump inhibitor or H2 blocker

In severe gastritis, bleeding is managed with IV fluids and blood transfusion as needed. Endoscopic hemostasis should be attempted, with surgery a fallback procedure if bleeding cannot be controlled endoscopically. Angiography is unlikely to stop severe gastric bleeding because of the many collateral vessels supplying the stomach. Acid-suppressing drugs Drug Treatment of Gastric Acidity Drugs for decreasing acidity are used for peptic ulcer, gastroesophageal reflux disease (GERD), and many forms of gastritis. Some drugs are used in regimens for treating Helicobacter pylori... read more should be started if the patient is not already receiving it.

Prevention of Erosive Gastritis

Prophylaxis with acid-suppressive drugs can reduce the incidence of acute stress gastritis. However, it mainly benefits certain high-risk intensive care unit patients, including those with severe burns, central nervous system trauma, coagulopathy, sepsis, shock, multiple trauma, mechanical ventilation for > 48 hours, chronic liver disease, acute kidney injury, hepatic or renal failure, multiorgan dysfunction, and history of peptic ulcer or gastrointestinal bleeding. A 2020 guideline for gastrointestinal bleeding prophylaxis for critically ill patients recommends that in most critically ill patients the benefit of acid suppression must be weighed against the risk of pneumonia. The guideline includes a calculator to help assess the risk of gastrointestinal bleeding. There is a possible increased risk of nosocomial pneumonia in critically ill patients receiving acid suppression. A recent meta-analysis concluded that proton pump inhibitors (PPIs) and histamine-2 receptor antagonists may increase the risk of pneumonia (absolute increases 5% for PPIs and 3.4% for histamine-2 receptor antagonists; 1 Treatment references Erosive gastritis is gastric mucosal erosion caused by damage to mucosal defenses. It is typically acute, manifesting with bleeding, but may be subacute or chronic with few or no symptoms. Diagnosis... read more Treatment references ). However, a previous large clinical study of a PPI for patients at risk of gastrointestinal bleeding in the intensive care unit found no increased incidence of pneumonia (2 Treatment references Erosive gastritis is gastric mucosal erosion caused by damage to mucosal defenses. It is typically acute, manifesting with bleeding, but may be subacute or chronic with few or no symptoms. Diagnosis... read more Treatment references ). The guideline further recommends using a PPI rather than a histamine-2 receptor antagonist (weak recommendation) and recommends against using sucralfate.

Early enteral feeding also can decrease the incidence of bleeding.

Acid suppression is not recommended for patients simply taking nonsteroidal anti-inflammatory drugs unless they have previously had an ulcer.

Treatment references

  • 1. Wang Y, Ye Z, Ge L, et al: Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: Systematic review and network meta-analysis. BMJ 368:l6744, 2020. doi: 10.1136/bmj.l6744PMCID

  • 2. Krag M, Marker S, Perner A, et al: Pantoprazole in patients at risk for gastrointestinal bleeding in the ICU. N Engl J Med 379(23):2199–2208, 2018. doi: 10.1056/NEJMoa1714919

More Information

The following is an English-language resource that may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

Drugs Mentioned In This Article

Drug Name Select Trade
PROTONIX
CARAFATE
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