Benign tumors include leiomyomas, lipomas, neurofibromas, and fibromas. All may cause abdominal distention, pain, bleeding, diarrhea, and, if obstruction develops, vomiting. Polyps are not as common as in the colon.
Adenocarcinoma, a malignant tumor, is uncommon. Usually it arises in the duodenum or proximal jejunum and causes minimal symptoms. In patients with Crohn disease involving the small-bowel, the tumors tend to occur distally and in bypassed or inflamed loops of bowel.
Primary malignant lymphoma Overview of Lymphoma Lymphomas are a heterogeneous group of tumors arising in the reticuloendothelial and lymphatic systems. The major types are Hodgkin lymphoma Non-Hodgkin lymphoma See table Comparison of Hodgkin... read more arising in the ileum may cause a long, rigid segment. Small-bowel lymphomas can arise in long-standing untreated celiac disease Celiac Disease Celiac disease is an immunologically mediated disease in genetically susceptible people caused by intolerance to gluten, resulting in mucosal inflammation and villous atrophy, which causes malabsorption... read more .
Carcinoid tumors Overview of Carcinoid Tumors Carcinoid tumors develop from neuroendocrine cells in the gastrointestinal tract (90%), pancreas, pulmonary bronchi, and rarely the genitourinary tract. More than 95% of all gastrointestinal... read more (also called gastrointestinal neuroendocrine tumors) occur most often in the small bowel, particularly the ileum, and in the appendix; in these locations, larger lesions can become malignant. Multiple tumors occur in 50% of cases. Of those > 2 cm in diameter, 80% have metastasized locally or to the liver by the time of operation. About 30% of small-bowel carcinoids cause obstruction, pain, bleeding, or carcinoid syndrome. Treatment of carcinoid tumors is surgical resection; repeat operations may be required. For metastatic carcinoid tumors, long-acting somatostatin analog therapy with dose escalation, peptide receptor radioligand therapy (PRRT) using a radiolabeled somatostatin analog, or everolimus can be used to effectively control the disease.
Kaposi sarcoma Kaposi Sarcoma Kaposi sarcoma is a multicentric vascular tumor caused by herpesvirus type 8. It can occur in classic, AIDS-associated, endemic (in Africa), and iatrogenic (eg, after organ transplantation)... read more , first described as a disease of elderly Jewish and Italian men, occurs in an aggressive form in Africans, transplant recipients, and AIDS patients, who have gastrointestinal (GI) tract involvement 40 to 60% of the time. Lesions may occur anywhere in the GI tract but usually in the stomach, small bowel, or distal colon. GI lesions usually are asymptomatic, but bleeding, diarrhea, protein-losing enteropathy, and intussusception may occur. Treatment of Kaposi sarcoma Treatment Kaposi sarcoma is a multicentric vascular tumor caused by herpesvirus type 8. It can occur in classic, AIDS-associated, endemic (in Africa), and iatrogenic (eg, after organ transplantation)... read more depends on the cell type and location and extent of the lesions.
1. Siegel RL, Miller KD, Jemal A: Cancer statistics, 2020. CA Cancer J Clin 70(1):7–30, 2020. doi: 10.3322/caac.21590
Diagnosis of Small-Bowel Tumors
Sometimes push endoscopy or capsule video endoscopy
Enteroclysis Enteroclysis X-ray and other imaging contrast studies visualize the entire gastrointestinal tract from pharynx to rectum and are most useful for detecting mass lesions and structural abnormalities (eg, tumors... read more (sometimes CT enteroclysis) is probably the most common study for mass lesions of the small bowel.
Push endoscopy of the small bowel with an enteroscope may be used to visualize and biopsy tumors.
Video capsule endoscopy Video Capsule Endoscopy Flexible endoscopes equipped with video cameras can be used to view the upper gastrointestinal tract from pharynx to proximal duodenum and the lower gastrointestinal tract from anus to cecum... read more can help identify small-bowel lesions, particularly bleeding sites; a swallowed capsule transmits 2 images/second to an external recorder. The original capsule is not useful in the stomach or colon because it tumbles in these larger organs; a colon capsule camera with better optics and illumination is under development for use in these larger-diameter organs.
Treatment of Small-Bowel Tumors
Treatment of small-bowel tumors is surgical resection.
Electrocautery, thermal obliteration, or laser phototherapy at the time of enteroscopy or surgery may be an alternative to resection.
Drugs Mentioned In This Article
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|Afinitor , Afinitor DISPERZ, Zortress|