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HACEK Infections

By

Larry M. Bush

, MD, FACP, Charles E. Schmidt College of Medicine, Florida Atlantic University;


Maria T. Vazquez-Pertejo

, MD, FACP, Wellington Regional Medical Center

Last full review/revision Feb 2020| Content last modified Feb 2020
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The HACEK group includes weakly virulent, gram-negative organisms that primarily cause endocarditis. Treatment is with antibiotics.

The HACEK group of nonmotile, gram-negative bacilli or coccobacilli contains a number of minimally pathogenic, slow-growing, fastidious genera. Their primary pathology is endocarditis Infective Endocarditis Infective endocarditis is infection of the endocardium, usually with bacteria (commonly, streptococci or staphylococci) or fungi. It may cause fever, heart murmurs, petechiae, anemia, embolic... read more Infective Endocarditis in susceptible people; about 5% of endocarditis cases are due to this group, making them the most common causes of gram-negative bacilli endocarditis. The group consists of

Antibiotic sensitivities differ among species, so treatment should be directed by susceptibility testing. However, increasing beta-lactam resistance has made ceftriaxone and ampicillin/sulbactam the current antibiotics of choice.

Drugs Mentioned In This Article

Drug Name Select Trade
ZITHROMAX
VIBRAMYCIN
FORTAZ, TAZICEF
CILOXAN, CIPRO
BACTRIM, SEPTRA
GENOPTIC
No US brand name
RIFADIN, RIMACTANE
No US brand name
ERY-TAB, ERYTHROCIN
No US brand name
UNASYN
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