Functions of T Cells
Type | Substances Produced | Primary Function |
|---|---|---|
Th1 | IFN-gamma IL-2 Lymphotoxin | Facilitate macrophage and cytotoxic T-cell responses |
Th2 | IL-4 IL-5 IL-6 IL-10 IL-13 | Stimulate antibody production by B cells |
Th17 | IL-17 IL-21 IL-22 | Promote inflammatory responses |
Tfh | IL-4 IL-10 IL-21 | Help germinal center B cells |
Tc | Perforin Granzymes FasL Cytokines* | Kill infected cells |
Regulatory | TGF-beta IL-10 IL-35 | Suppress immune responses |
Activated NKT cells | IL-4 IFN-gamma | May help regulate immune responses |
* Tc can be subdivided into Tc1, Tc2, and Tc17 based upon analogous cytokine production to Th1, Th2, and Th17 cells. | ||
FasL = Fas ligand; IFN = interferon; IL = interleukin; NK = natural killer; Tc = cytotoxic T cell; TGF = transforming growth factor; Th = helper T cell. | ||
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