Merck Manual

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Overview of Osteochondroses


Frank Pessler

, MD, PhD, Hannover, Germany

Last full review/revision Oct 2020| Content last modified Oct 2020
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Osteochondroses are noninflammatory, noninfectious derangements of bony growth at various ossification centers. These derangements occur during the period of greatest developmental activity and affect the epiphyses.

Etiology of osteochondroses is typically unknown; some of the disorders have a familial component, but inheritance is complex. Osteochondroses differ in their anatomic distribution, course, and prognosis; they typically cause pain and have important orthopedic implications. Common examples include

Rare osteochondroses and the involved bones include Freiberg disease (head of 2nd metatarsal), Panner disease (capitulum), and Blount disease (proximal tibia). Sever disease (calcaneal apophysitis) is a more common osteochondrosis.

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