Hereditary periodic fever syndromes are hereditary disorders characterized by recurrent fever and other symptoms that are not explained by other causes.
Most patients develop symptoms during childhood; < 10% develop symptoms after age 18. Disorders best characterized are
Other disorders include
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The hereditary cryopyrin-associated periodic syndromes (cryopyrinopathies): Familial cold autoinflammatory syndrome, Muckle-Wells syndrome, and neonatal-onset multisystem inflammatory disease (NOMID)
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PAPA (pyogenic arthritis, pyoderma gangrenosum, and acne) syndrome
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PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis) syndrome, which may not be hereditary
