Bipolar disorders usually begin in the teens, 20s, or 30s (see also Bipolar Disorder in Children and Adolescents Bipolar Disorder in Children and Adolescents Bipolar disorder is characterized by alternating periods of mania, depression, and normal mood, each lasting for weeks to months at a time. Diagnosis is based on clinical criteria. Treatment... read more ). Lifetime prevalence is about 4%.
Bipolar disorders are classified as
Bipolar I disorder: Defined by the presence of at least one full-fledged (ie, disrupting normal social and occupational function) manic episode and usually depressive episodes. Incidence is about equal in men and women.
Bipolar II disorder: Defined by the presence of major depressive episodes with at least one hypomanic episode but no full-fledged manic episodes. Incidence is somewhat higher for females.
Unspecified bipolar disorder: Disorders with clear bipolar features that do not meet the specific criteria for other bipolar disorders
In cyclothymic disorder Cyclothymic Disorder Cyclothymic disorder is characterized by hypomanic and mini-depressive periods that last a few days, follow an irregular course, and are less severe than those in bipolar disorder; these symptom... read more , patients have prolonged (> 2-year) periods that include both hypomanic and depressive episodes; however, these episodes do not meet the specific criteria for a bipolar or major depressive disorder.
(See also Overview of Mood Disorders Overview of Mood Disorders Mood disorders are emotional disturbances consisting of prolonged periods of excessive sadness, excessive joyousness, or both. Mood disorders can occur in children and adolescents (see Depressive... read more .)
Etiology of Bipolar Disorders
The exact cause of bipolar disorder is unknown. Heredity plays a significant role. There is also evidence of dysregulation of the neurotransmitters serotonin, norepinephrine, and dopamine.
Psychosocial factors may be involved. Stressful life events are often associated with initial development of symptoms and later exacerbations, although cause and effect have not been established.
Certain drugs can trigger exacerbations in some patients with bipolar disorder; these drugs include
Sympathomimetics (eg, cocaine Cocaine Cocaine is a sympathomimetic drug with central nervous system stimulant and euphoriant properties. High doses can cause panic, schizophrenic-like symptoms, seizures, hyperthermia, hypertension... read more , amphetamines Amphetamines Amphetamines are sympathomimetic drugs with central nervous system stimulant and euphoriant properties whose toxic adverse effects include delirium, hypertension, seizures, and hyperthermia... read more )
Certain antidepressants Drug Treatment of Depression Several drug classes and drugs can be used to treat depression: Selective serotonin reuptake inhibitors (SSRIs) Serotonin modulators (5-HT2 blockers) Serotonin-norepinephrine reuptake inhibitors... read more (eg, tricyclics, noradrenergic reuptake inhibitors)
Symptoms and Signs of Bipolar Disorders
Bipolar disorder begins with an acute phase of symptoms, followed by a repeating course of remission and relapse. Remissions are often complete, but many patients have residual symptoms, and for some, the ability to function at work is severely impaired. Relapses are discrete episodes of more intense symptoms that are manic, depressive, hypomanic, or a mixture of depressive and manic features.
Episodes last anywhere from a few weeks to 3 to 6 months; depressive episodes typically last longer than manic or hypomanic ones.
Cycles—time from onset of one episode to that of the next—vary in length among patients. Some patients have infrequent episodes, perhaps only a few over a lifetime, whereas others have rapid-cycling forms (usually defined as ≥ 4 episodes/year). Only a minority alternate back and forth between mania and depression with each cycle; in most, one or the other predominates.
Patients may attempt or complete suicide Suicidal Behavior Suicide is death caused by an intentional act of self-harm that is designed to be lethal. Suicidal behavior encompasses a spectrum of behavior from suicide attempt and preparatory behaviors... read more . Lifetime incidence of suicide in patients with bipolar disorder is estimated to be at least 15 times that of the general population.
A manic episode is defined as ≥ 1 week of a persistently elevated, expansive, or irritable mood and persistently increased goal-directed activity or a noticeable increase of energy plus ≥ 3 additional symptoms:
Inflated self-esteem or grandiosity
Decreased need for sleep
Greater talkativeness than usual
Flight of ideas or racing of thoughts
Increased goal-directed activity
Excessive involvement in activities with high potential for painful consequences (eg, buying sprees, foolish business investments)
Manic patients may be inexhaustibly, excessively, and impulsively involved in various pleasurable, high-risk activities (eg, gambling, dangerous sports, promiscuous sexual activity) without insight into possible harm. Symptoms are so severe that they cannot function in their primary role (occupation, school, housekeeping). Unwise investments, spending sprees, and other personal choices may have irreparable consequences.
Patients in a manic episode may be exuberant and flamboyantly or colorfully dressed and often have an authoritative manner with a rapid, unstoppable flow of speech. Patients may make clang associations (new thoughts that are triggered by word sounds rather than meaning). Easily distracted, patients may constantly shift from one theme or endeavor to another. However, they tend to believe they are in their best mental state.
Lack of insight and an increased capacity for activity often lead to intrusive behavior and can be a dangerous combination. Interpersonal friction results and may cause patients to feel that they are being unjustly treated or persecuted. As a result, patients may become a danger to themselves or to other people. Accelerated mental activity is experienced as racing thoughts by patients and is observed as flights of ideas by the physician.
Manic psychosis is a more extreme manifestation, with psychotic symptoms that may be difficult to distinguish from schizophrenia Schizophrenia Schizophrenia is characterized by psychosis (loss of contact with reality), hallucinations (false perceptions), delusions (false beliefs), disorganized speech and behavior, flattened affect... read more . Patients may have extreme grandiose or persecutory delusions (eg, of being Jesus or being pursued by the FBI), occasionally with hallucinations. Activity level increases markedly; patients may race about and scream, swear, or sing. Mood lability increases, often with increasing irritability. Full-blown delirium (delirious mania) may appear, with complete loss of coherent thinking and behavior.
A hypomanic episode is a less extreme variant of mania involving a distinct episode that lasts ≥ 4 days with behavior that is distinctly different from the patient’s usual nondepressed self and that includes ≥ 3 of the additional symptoms listed above under mania.
During the hypomanic period, mood brightens, the need for sleep decreases as energy noticeably increases, and psychomotor activity accelerates. For some patients, hypomanic periods are adaptive because they produce high energy, creativity, confidence, and supernormal social functioning. Many do not wish to leave the pleasurable, euphoric state. Some function quite well, and functioning is not markedly impaired. However, in some patients, hypomania manifests as distractibility, irritability, and labile mood, which the patient and others find less attractive.
A depressive episode has features typical of major depression Major depression (unipolar disorder) Depressive disorders are characterized by sadness severe enough or persistent enough to interfere with function and often by decreased interest or pleasure in activities. Exact cause is unknown... read more ; the episode must include ≥ 5 of the following during the same 2-week period, and one of them must be depressed mood or loss of interest or pleasure and, with the exception of suicidal thoughts or attempts, all symptoms must be present nearly every day:
Depressed mood most of the day
Markedly diminished interest or pleasure in all or almost all activities for most of the day
Significant (>5%) weight gain or loss or decreased or increased appetite
Insomnia (often sleep-maintenance insomnia) or hypersomnia
Psychomotor agitation or retardation observed by others (not self-reported)
Fatigue or loss of energy
Feelings of worthlessness or excessive or inappropriate guilt
Diminished ability to think or concentrate or indecisiveness
Recurrent thoughts of death or suicide, a suicide attempt, or specific plan for suicide
Psychotic features are more common in bipolar depression than in unipolar depression.
An episode of mania or hypomania is designated as having mixed features if ≥ 3 depressive symptoms are present for most days of the episode. This condition is often difficult to diagnose and may shade into a continuously cycling state; the prognosis is then worse than that in a pure manic or hypomanic state.
Risk of suicide during mixed episodes is particularly high.
Diagnosis of Bipolar Disorders
Clinical criteria (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition)
Thyroxine (T4) and thyroid-stimulating hormone (TSH) levels to exclude hyperthyroidism
Exclusion of stimulant drug abuse clinically or by blood or urine testing
Diagnosis of bipolar disorder is based on identification of symptoms of mania or hypomania as described above, plus a history of remission and relapse. A diagnosis of bipolar I disorder requires manic symptoms severe enough to markedly impair social or occupational functioning or to require hospitalization to prevent harm to self or others.
Some patients who present with depressive symptoms may have previously experienced hypomania or mania but do not report it unless they are specifically questioned. Skillful questioning may reveal morbid signs (eg, excesses in spending, impulsive sexual escapades, stimulant drug abuse), although such information is more likely to be provided by relatives. A structured inventory such as the Mood Disorder Questionnaire may be useful. All patients must be asked gently but directly about suicidal ideation, plans, or activity.
Similar acute manic or hypomanic symptoms may result from stimulant abuse or physical disorders such as hyperthyroidism Hyperthyroidism Hyperthyroidism is characterized by hypermetabolism and elevated serum levels of free thyroid hormones. Symptoms include palpitations, fatigue, weight loss, heat intolerance, anxiety, and tremor... read more or pheochromocytoma Pheochromocytoma A pheochromocytoma is a catecholamine-secreting tumor of chromaffin cells typically located in the adrenals. It causes persistent or paroxysmal hypertension. Diagnosis is by measuring catecholamine... read more . Patients with hyperthyroidism typically have other physical symptoms and signs, but thyroid function testing (T4 and TSH levels) is a reasonable screen for new patients. Patients with pheochromocytoma have marked intermittent or sustained hypertension; if hypertension is absent, testing for pheochromocytoma is not indicated. Other disorders less commonly cause symptoms of mania, but depressive symptoms may occur in a number of disorders (see table Some Causes of Symptoms of Depression and Mania Some Causes of Symptoms of Depression and Mania* ).
A review of substance use (especially of amphetamines Amphetamines Amphetamines are sympathomimetic drugs with central nervous system stimulant and euphoriant properties whose toxic adverse effects include delirium, hypertension, seizures, and hyperthermia... read more and cocaine Cocaine Cocaine is a sympathomimetic drug with central nervous system stimulant and euphoriant properties. High doses can cause panic, schizophrenic-like symptoms, seizures, hyperthermia, hypertension... read more ) and blood or urine drug screening can help identify drug causes. However, because drug use may simply have triggered an episode in a patient with bipolar disorder, seeking evidence of symptoms (manic or depressive) not related to drug use is important.
Some patients with schizoaffective disorder Schizoaffective Disorder Schizoaffective disorder is characterized by psychosis, other symptoms of schizophrenia, and significant mood symptoms. It is differentiated from schizophrenia by occurrence of ≥ 1 episode of... read more have manic symptoms, but such patients have psychotic features that may persist beyond the abnormal mood episodes.
Patients with bipolar disorder may also have anxiety disorders (eg, social phobia Social Phobia Social phobia is fear of and anxiety about being exposed to certain social or performance situations. These situations are avoided or endured with substantial anxiety. Phobias are a type of... read more , panic attacks Panic Attacks and Panic Disorder A panic attack is the sudden onset of a discrete, brief period of intense discomfort, anxiety, or fear accompanied by somatic and/or cognitive symptoms. Panic disorder is occurrence of repeated... read more , obsessive-compulsive disorders Obsessive-Compulsive Disorder (OCD) Obsessive-compulsive disorder (OCD) is characterized by recurrent, persistent, unwanted, and intrusive thoughts, urges, or images (obsessions) and/or by repetitive behaviors or mental acts that... read more ), possibly confusing the diagnosis.
Treatment of Bipolar Disorders
(See also Drug Treatment of Bipolar Disorder Drug Treatment of Bipolar Disorders Choice of drug treatment for bipolar disorders can be difficult because all drugs have significant adverse effects, drug interactions are common, and no drug is universally effective. Selection... read more .)
Mood stabilizers (eg, lithium, certain anticonvulsants), a 2nd-generation antipsychotic, or both
Support and psychotherapy
Treatment of bipolar disorder usually has 3 phases:
Acute: To stabilize and control the initial, sometimes severe manifestations
Continuation: To attain full remission
Maintenance or prevention: To keep patients in remission
Although most patients with hypomania can be treated as outpatients, severe mania or depression often requires inpatient management.
Drug therapy for bipolar disorder
Drugs for bipolar disorder Drug Treatment of Bipolar Disorders Choice of drug treatment for bipolar disorders can be difficult because all drugs have significant adverse effects, drug interactions are common, and no drug is universally effective. Selection... read more include
Mood stabilizers: Lithium and certain anticonvulsants, especially valproate, carbamazepine, and lamotrigine
2nd-generation antipsychotics Second-generation antipsychotics Antipsychotic drugs are divided into conventional antipsychotics and 2nd-generation antipsychotics (SGAs) based on their specific neurotransmitter receptor affinity and activity. SGAs may offer... read more : Aripiprazole, lurasidone, olanzapine, quetiapine, risperidone, ziprasidone, and cariprazine.
These drugs are used alone or in combination for all phases of treatment, although at different dosages.
Choice of drug treatment Drug Treatment of Bipolar Disorders Choice of drug treatment for bipolar disorders can be difficult because all drugs have significant adverse effects, drug interactions are common, and no drug is universally effective. Selection... read more for bipolar disorder can be difficult because all drugs have significant adverse effects, drug interactions are common, and no drug is universally effective. Selection should be based on what has previously been effective and well-tolerated in a given patient. If the patient has not previously been given drugs to treat bipolar disorder (or drug history is unknown), choice is based on the patient’s medical history (vis-à-vis the adverse effects of the specific mood stabilizer) and the severity of symptoms.
Specific antidepressants Drug Treatment of Depression Several drug classes and drugs can be used to treat depression: Selective serotonin reuptake inhibitors (SSRIs) Serotonin modulators (5-HT2 blockers) Serotonin-norepinephrine reuptake inhibitors... read more (eg, selective serotonin reuptake inhibitors [SSRIs]) are sometimes added for severe depression, but their effectiveness is controversial; they are not recommended as sole therapy for depressive episodes. Ketamine infusion has also been shown to be effective in the treatment of severe bipolar depression.
Electroconvulsive therapy Electroconvulsive therapy (ECT) Depressive disorders are characterized by sadness severe enough or persistent enough to interfere with function and often by decreased interest or pleasure in activities. Exact cause is unknown... read more (ECT) is sometimes used for depression refractory to treatment and is also effective for mania.
Phototherapy Phototherapy Depressive disorders are characterized by sadness severe enough or persistent enough to interfere with function and often by decreased interest or pleasure in activities. Exact cause is unknown... read more can be useful in treating depressive symptoms of seasonal (with autumn-winter depression and spring-summer hypomania) or nonseasonal bipolar I or bipolar II disorder. It is probably most useful as augmentative therapy.
Transcranial magnetic stimulation, which is sometimes used to treat severe, resistant depression, has also proven effective in bipolar depression.
Education and psychotherapy
Enlisting the support of loved ones is crucial to preventing major episodes.
Group therapy is often recommended for patients and their partner; there, they learn about bipolar disorder, its social sequelae, and the central role of mood stabilizers in treatment.
Individual psychotherapy may help patients better cope with problems of daily living and adjust to a new way of identifying themselves.
Patients, particularly those with bipolar II disorder, may not adhere to mood-stabilizer regimens because they believe that these drugs make them less alert and creative. The physician can explain that decreased creativity is relatively uncommon because mood stabilizers usually provide opportunity for a more even performance in interpersonal, scholastic, professional, and artistic pursuits.
Patients should be counseled to avoid stimulant drugs and alcohol, to minimize sleep deprivation, and to recognize early signs of relapse.
If patients tend to be financially extravagant, finances should be turned over to a trusted family member. Patients with a tendency to sexual excesses should be given information about conjugal consequences (eg, divorce) and infectious risks of promiscuity, particularly AIDS.
Support groups (eg, the Depression and Bipolar Support Alliance [DBSA] ) can help patients by providing a forum to share their common experiences and feelings.
Bipolar disorder is a cyclic condition that involves episodes of mania with or without depression (bipolar 1) or hypomania plus depression (bipolar 2).
Bipolar disorder markedly impairs the ability to function at work and to interact socially, and risk of suicide is significant; however, mild manic states (hypomania) are sometimes adaptive because they can produce high energy, creativity, confidence, and supernormal social functioning.
Length and frequency of cycles vary among patients; some patients have only a few over a lifetime, whereas others have ≥ 4 episodes/year (rapid-cycling forms).
Only a few patients alternate back and forth between mania and depression during each cycle; in most cycles, one or the other predominates.
Diagnosis is based on clinical criteria, but stimulant use disorder and physical disorders (such as hyperthyroidism or pheochromocytoma) must be ruled out by examination and testing.
Treatment depends on the manifestations and their severity but typically involves mood stabilizers (eg, lithium, valproate, carbamazepine, lamotrigine) and/or 2nd-generation antipsychotics (eg, aripiprazole, lurasidone, olanzapine, quetiapine, risperidone, ziprasidone, cariprazine).
Drugs Mentioned In This Article
|Drug Name||Select Trade|
|Eskalith, Eskalith CR, Lithobid|
|Carbatrol, Epitol , Equetro, Tegretol, Tegretol -XR|
|Lamictal, Lamictal CD, Lamictal ODT, Lamictal XR, Subvenite|
|Abilify, Abilify Discmelt, Abilify Maintena, Abilify Mycite, Aristada|
|Zyprexa, Zyprexa Intramuscular, Zyprexa Relprevv, Zyprexa Zydis|
|Seroquel, Seroquel XR|
|PERSERIS, Risperdal, Risperdal Consta, Risperdal M-Tab|