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Airway Tumors


Robert L. Keith

, MD, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine

Reviewed/Revised May 2023

The airway can be affected by primary tracheobronchial tumors, primary tumors that are adjacent to and invade or compress the airway, or cancers that metastasize to the airway.

Primary tracheal tumors are rare. They are often malignant and found at a locally advanced stage. Other tumors (eg, thyroid, lung) can locally invade the airways.

The most common malignant tracheal tumors include

  • Adenoid cystic carcinoma

  • Squamous cell carcinoma

  • Carcinoid

  • Mucoepidermoid carcinomas

The most common benign airway tumor is a

Pleomorphic adenomas and granular cell and benign cartilaginous tumors also occur.

Symptoms and Signs of Airway Tumors

Patients often present with

  • Dyspnea

  • Cough

  • Wheezing

  • Hemoptysis

  • Stridor

Hemoptysis, while uncommon, more often occurs with a squamous cell carcinoma and can potentially lead to earlier diagnosis, whereas wheezing or stridor occurs more often with the adenoid cystic variant. Dysphagia and hoarseness can also be present initially and usually indicate advanced disease.

Diagnosis of Airway Tumors

  • Bronchoscopic biopsy

Symptoms of airway narrowing (eg, stridor, dyspnea, wheezing) can herald life-threatening airway obstruction. An airway tumor should be considered a possible cause if such symptoms are unexplained, are of gradual onset, are associated with other symptoms of airway tumors (eg, unexplained hemoptysis), and respond poorly to standard treatments (eg, if aggressive asthma treatments do not relieve wheezing, or antibiotics for apparent pneumonia do not reduce symptoms and improve x-ray findings).

Treatment of Airway Tumors

  • Surgery

  • Sometimes radiation therapy

  • Obstruction reduction techniques

Primary airway tumors should be treated definitively with surgical resection if possible. Tracheal, laryngotracheal, or carinal resections are the most common procedures. Up to 50% of the length of the trachea can be safely resected with primary reanastomosis. If a lung or thyroid cancer invades the airway, surgery is sometimes still feasible if assessment indicates sufficient tissue is available for airway reconstruction. Adjuvant radiation therapy is recommended if adequate surgical margins cannot be obtained.

Most primary airway tumors are not resectable because of metastasis, locally advanced stage, or patient comorbidities. In cases of endoluminal tumors, therapeutic bronchoscopy can mechanically core-out the tumor. Other techniques to eliminate obstruction include laser vaporization, photodynamic therapy, cryotherapy, and endobronchial brachytherapy. Tumors that compress the trachea are treated with airway stenting, radiation therapy, or both.

Prognosis for Airway Tumors

Prognosis depends on the histology.

Squamous cell carcinomas tend to metastasize to regional lymph nodes and directly invade mediastinal structures, leading to high local and regional recurrence rates. Even with definitive surgical resection, the 5-year survival is < 40% (1 Prognosis reference The airway can be affected by primary tracheobronchial tumors, primary tumors that are adjacent to and invade or compress the airway, or cancers that metastasize to the airway. Primary tracheal... read more ).

Adenoid cystic carcinomas are typically indolent but tend to metastasize to the lungs and to spread perineurally, leading to high recurrence rates after resection. However, these patients have a 5-year survival of about 60 to 75% because of the slow tumor growth rate.

Prognosis reference

  • 1. Gaissert HA, Grillo HC, Shadmehr MB, et al: Long-term survival after resection of primary adenoid cystic and squamous cell carcinoma of the trachea and carina. Ann Thorac Surg 78(6):1889-1897, 2004. doi:10.1016/j.athoracsur.2004.05.064

Key Points

  • Primary tracheal tumors are rare, often malignant, and commonly locally advanced when recognized.

  • Suspect airway tumors in patients with gradual, unexplained, or intractable dyspnea, cough, wheezing, hemoptysis, and stridor.

  • Hemoptysis may occur but is uncommon and typically is from squamous cell carcinoma

  • Treat with local resection or, if resection is not indicated, other locally destructive therapies.

NOTE: This is the Professional Version. CONSUMERS: View Consumer Version
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