Merck Manual

Please confirm that you are a health care professional

honeypot link



Laura Shane-McWhorter

, PharmD, University of Utah College of Pharmacy

Reviewed/Revised Jan 2023

The flower of chamomile is dried and drunk as a tea, consumed as a capsule, or used topically as an extract.


Chamomile tea is said to reduce inflammation and fever, to act as a mild sedative, to provide antidepressant activity, to relieve stomach cramps and indigestion, and to promote healing of gastric ulcers. Chamomile extract applied topically in a compress is said to soothe irritated skin. Mechanism is due to essential oil containing bisabolol constituents and the flavonoids apigenin and luteolin.


Adverse Effects

Chamomile is generally safe; however, hypersensitivity reactions have been reported, especially in people allergic to members of the Asteraceae (eg, sunflower, ragweed) plant family and pollen of all flowering plants. Typical symptoms include lacrimation, sneezing, gastrointestinal upset, dermatitis, and anaphylaxis.

Drug Interactions

Chamomile may increase the effects of anticoagulants and sedatives (including barbiturates and alcohol).

Chamomile could interfere with the effects of tamoxifen, hormone replacement therapy, and estrogen-containing oral contraceptives. Chamomile may also increase cyclosporine serum concentrations (5 References The flower of chamomile is dried and drunk as a tea, consumed as a capsule, or used topically as an extract. (See also Overview of Dietary Supplements and National Institutes of Health (NIH)... read more ).

(See also table .)


  • 1. Amsterdam JD, Li Y, Soeller I, et al: A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. J Clin Psychopharmacol 29(4):378-382, 2009. doi: 10.1097/JCP.0b013e3181ac935c

  • 2. Keefe JR, Mao JJ, et al: Short-term open-label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder. Phytomedicine 23(14):1699-1705, 2016. doi: 10.1016/j.phymed.2016.10.013

  • 3. Amsterdam JD, Li QS, Xie SX, et al: Putative antidepressant effect of chamomile (Matricaria chamomilla L.) oral extract in subjects with comorbid generalized anxiety disorder and depression. J Altern Complement Med 26(9):813-819, 2020. doi:10.1089/acm.2019.0252

  • 4. Hieu TH, Dibas M, Dila KAS, et al: Therapeutic efficacy and safety of chamomile for state anxiety, generalized anxiety disorder, insomnia, and sleep quality: a systematic review and meta-analysis of randomized trials and quasi-randomized trials. Phytother Res 33:1604-1615, 2019. doi: 10.1002/ptr.6349

  • 5. Nowack R, Nowak B: Herbal teas interfere with cyclosporin levels in renal transplant patients. Nephrol Dial Transplant 20(11):2554-2556, 2005. doi:10.1093/ndt/gfi003

More Information

The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

Drugs Mentioned In This Article

Drug Name Select Trade
Nolvadex, Soltamox
Cequa, Gengraf , Neoral, Restasis, Sandimmune, SangCya, Verkazia
NOTE: This is the Professional Version. CONSUMERS: View Consumer Version
quiz link

Test your knowledge

Take a Quiz!