Overview of the Immune System
The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. The immune system also has the capacity to recognize and destroy abnormal cells that derive from host tissues. Any molecule capable of being recognized by the immune system is considered an antigen (Ag).
The skin, cornea, and mucosa of the respiratory, GI, and GU tracts form a physical barrier that is the body's first line of defense. Some of these barriers also have active immune functions:
Outer, keratinized epidermis: Keratinocytes in the skin secrete antimicrobial peptides (defensins), and sebaceous and sweat glands secrete microbe-inhibiting substances (eg, lactic acid, fatty acids). Also, many immune cells (eg, mast cells, intraepithelial lymphocytes, Ag-sampling Langerhans cells) reside in the skin.
Mucosa of the respiratory, GI, and GU tracts: The mucus contains antimicrobial substances, such as lysozyme, lactoferrin, and secretory IgA antibody (SIgA).
Breaching of anatomic barriers can trigger 2 types of immune response:
Many molecular components (eg, complement, cytokines, acute phase proteins) participate in both innate and acquired immunity.
Innate (natural) immunity does not require prior exposure to an Ag (ie, immunologic memory) to be effective. Thus, it can respond immediately to an invader. It recognizes mainly Ag molecules that are broadly distributed rather than specific to one organism or cell.
Phagocytic cells (neutrophils in blood and tissues, monocytes in blood, macrophages in tissues) ingest and destroy invading Ags. Attack by phagocytic cells can be facilitated when Ags are coated with antibody (Ab), which is produced as part of acquired immunity, or when complement proteins opsonize Ags.
Natural killer cells kill virus-infected cells and some tumor cells.
Acquired (adaptive) immunity requires prior exposure to an Ag and thus takes time to develop after the initial encounter with a new invader. Thereafter, response is quick. The system remembers past exposures and is Ag-specific.
Acquired immunity includes
B cells and T cells work together to destroy invaders. Antigen-presenting cells are needed to present Ags to T cells.
Successful immune defense requires activation, regulation, and resolution of the immune response.
The immune system is activated when a foreign antigen (Ag) is recognized by circulating antibodies (Abs) or cell surface receptors. These receptors may be
Broadly specific receptors recognize common microbial pathogen-associated molecular patterns in ligands, such as gram-negative lipopolysaccharide, gram-positive peptidoglycans, bacterial flagellin, unmethylated cytosine-guanosine dinucleotides (CpG motifs), and viral double-stranded RNA. These receptors can also recognize molecules that are produced by stressed or infected human cells (called damage-associated molecular patterns).
Activation may also occur when Ab-Ag and complement-microorganism complexes bind to surface receptors for the crystallizable fragment (Fc) region of IgG (Fc-gamma R) and for C3b and iC3b.
Once recognized, an Ag, Ag-Ab complex, or complement-microorganism complex is phagocytosed. Most microorganisms are killed after they are phagocytosed, but others inhibit the phagocyte’s intracellular killing ability (eg, mycobacteria that have been engulfed by a macrophage inhibit that cell's killing ability). In such cases, T cell–derived cytokines, particularly interferon-gamma (IFN-gamma), stimulate the phagocyte to produce more lytic enzymes and other microbicidal products and thus enhance its ability to kill or sequester the microorganism.
Unless Ag is rapidly phagocytosed and entirely degraded (an uncommon event), the acquired immune response is recruited. This response begins in
For example, Langerhans dendritic cells in the skin phagocytose Ag and migrate to local lymph nodes; there, peptides derived from the Ag are expressed on the cell surface within class II major histocompatibility complex (MHC) molecules, which present the peptide to CD4 helper T (TH) cells. When the THcell engages the MHC-peptide complex and receives various costimulatory signals, it is activated to express receptors for the cytokine IL-2 and secretes several cytokines. Each subset of TH cells secretes different combinations of substances and thus effect different immune responses.
Class II MHC molecules typically present peptides derived from extracellular (exogenous) Ag (eg, from many bacteria) to CD4 TH cells; in contrast, class I MHC molecules typically present peptides derived from intracellular (endogenous) Ag (eg, from viruses) to CD8 cytotoxic T cells. The activated cytotoxic T cell then kills the infected cell.
The immune response must be regulated to prevent overwhelming damage to the host (eg, anaphylaxis, widespread tissue destruction). Regulatory T cells (most of which express Foxp3 transcription factor) help control the immune response via secretion of immunosuppressive cytokines, such as IL-10 and transforming growth factor-beta (TGF-beta), or via a poorly defined cell contact mechanism.
These regulatory cells help prevent autoimmune responses and probably help resolve ongoing responses to nonself Ag.
The immune response resolves when Ag is sequestered or eliminated from the body. Without stimulation by Ag, cytokine secretion ceases, and activated cytotoxic T cells undergo apoptosis. Apoptosis tags a cell for immediate phagocytosis, which prevents spillage of the cellular contents and development of subsequent inflammation. T and B cells that have differentiated into memory cells are spared this fate.
With aging, the immune system becomes less effective in the following ways:
The immune system becomes less able to distinguish self from nonself, making autoimmune disorders more common.
Macrophages destroy bacteria, cancer cells, and other antigens (Ag) more slowly, possibly contributing to the increased incidence of cancer among the elderly.
T cells respond less quickly to Ag.
There are fewer lymphocytes that can respond to new Ag.
The aging body produces less complement in response to bacterial infections.
Although overall antibody (Ab) concentration does not decline significantly, the binding affinity of Ab to Ag is decreased, possibly contributing to the increased incidence of pneumonia, influenza, infectious endocarditis, and tetanus and the increased risk of death due to these disorders among the elderly. These changes may also partly explain why vaccines are less effective in the elderly.