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Acute Infectious Arthritis

by Steven Schmitt, MD

Acute infectious arthritis is a joint infection that evolves over hours or days. The infection resides in synovial or periarticular tissues and is usually bacterial—in younger adults, frequently Neisseria gonorrhoeae. However, nongonococcal bacterial infections can also occur and can rapidly destroy joint structures. Symptoms include rapid onset of pain, effusion, and restriction of both active and passive range of motion, usually within a single joint. Diagnosis requires synovial fluid analysis and culture. Treatment is IV antibiotics and drainage of pus from joints.

Acute infectious arthritis may occur in children. About 50% of children with joint infection are < 3 yr. However, routine childhood vaccination for Haemophilus influenzae and Streptococcus pneumoniae is decreasing the incidence of joint infection in this age group.

Risk factors are listed in Risk Factors for Infectious Arthritis.

Risk is substantially increased in patients with RA and other disorders causing chronic joint damage, a past history of joint infection, injection drug use, or a prosthetic joint (see Prosthetic Joint Infectious Arthritis). RA patients are at particular risk of bacterial arthritis (prevalence 0.3 to 3.0%; annual incidence 0.5%). Most children who develop infectious arthritis do not have identified risk factors.

Risk Factors for Infectious Arthritis

Advanced age (50% of adults are > 60 yr)

Alcoholism

Arthrocentesis or joint surgery

Bacteremia

Cancer

Chronic medical illness (eg, lung or liver disease)

Diabetes

Hemodialysis

Hemophilia

History of previous joint infection

Immunodeficiency, including HIV

Immunosuppressive therapy, including corticosteroids

Injection drug use

Prosthetic joint implant

RA

Risk factors for sexually transmitted diseases (eg, multiple sex partners, absence of barrier precautions)

Sickle cell disease

Skin infections

SLE

Etiology

Infectious organisms reach joints by direct penetration (eg, trauma, surgery, arthrocentesis, bites), extension from an adjacent infection (eg, osteomyelitis, a soft-tissue abscess, an infected wound), or hematogenous spread from a remote site of infection.

In adults, most cases result from bacteria and are classified as gonococcal or nongonococcal. This distinction is important because gonococcal infections are far less destructive to the joint. In adults overall, Staphylococcus aureus tends to be the most frequent cause of infectious arthritis. Methicillin resistance has become more common among community isolates of S. aureus.

In young adults and adolescents, Neisseria gonorrhoeaeis the most common cause and results when N. gonorrhoeae spreads from infected mucosal surfaces (cervix, urethra, rectum, pharynx) via the bloodstream. Affected patients often have simultaneous genital infections with Chlamydia trachomatis (see Chlamydial, Mycoplasmal, and Ureaplasmal Mucosal Infections). Streptococcus species are also frequent causes, particularly in patients with polyarticular infections. Patients receiving immunosuppressive therapy (eg, with TNF inhibitors or corticosteroids) may have septic arthritis from less common pathogens (mycobacteria, fungi).

Pathophysiology

Infecting organisms multiply in the synovial fluid and synovial lining. Some bacteria (eg, S. aureus) produce virulence factors (adhesins), which allow bacteria to penetrate, remain within, and infect joint  tissues. Other bacterial products (eg, endotoxin from gram-negative organisms, cell wall fragments, exotoxins from gram-positive organisms, immune complexes formed by bacterial antigens and host antibodies) augment the inflammatory reaction.

PMNs migrate into the joint and phagocytose the infecting organisms. Phagocytosis of bacteria also results in PMN autolysis with release of lysosomal enzymes into the joint, which damage synovia, ligaments, and cartilage. Therefore, PMNs are both the major host defense system and the cause of joint damage. Articular cartilage can be destroyed within hours or days.

Inflammatory synovitis may occasionally persist even after the infection has been eradicated by antibiotics. Particularly in gonococcal cases, persistent antigen debris from bacteria or infection may alter cartilage, causing it to become antigenic, and—together with the adjuvant effects of bacterial components and immune complexes—immune-mediated, “sterile,” chronic inflammatory synovitis may develop.

Organisms That Commonly Cause Acute Infectious Arthritis

Patient Group

Organism

Typical Sources

Adults and adolescents

Gonococci (in young adults of reproductive age), nongonococcal bacteria ( Staphylococcus aureus, streptococci), Neisseria meningitidis in unusual cases

Cervical, urethral, rectal, or pharyngeal infection with bacteremic dissemination (for gonococci); bacteremia (for staphylococci and streptococci)

Neonates

Group B streptococci, Escherichia coli (and other gram-negative enteric bacteria), S. aureus

Maternal-fetal transmission; IV punctures or catheters with bacteremic dissemination

Children 3 yr

Streptococcus pyogenes, Streptococcus pneumoniae, S. aureus

Bacteremia (eg, otitis media, URIs, skin infections, meningitis)

Age 3 yr to adolescence

S. aureus, streptococci, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Kingella kingae

Bacteremia or contiguous spread

Children with meningitis, bacteremia, or palpable purpura

N. meningitidis (uncommon)

Bacteremia

All ages

Viruses (eg, parvovirus B19; hepatitis B or hepatitis C virus; rubella virus [active infection and after immunization]; togavirus; chikungunya virus; varicella virus; mumps virus [in adults]; adenovirus; coxsackieviruses A9, B2, B3, B4, and B6; retroviruses, including HIV; Epstein-Barr virus)

Viremia or immune complex deposition

Patients with possible tick exposure

Borrelia burgdorferi (causing Lyme disease)

Bacteremia

Patients with bite wounds (human, dog or cat, rat)

Often polymicrobial

Human: Eikenella corrodens, group B streptococci, S. aureus, oral anaerobes (eg, Fusobacterium sp, peptostreptococci, Bacteroides sp)

Dog or cat: S. aureus, Pasteurella multocida, Pseudomonas sp, Moraxella sp, Haemophilus sp

Rat: S. aureus, Streptobacillus moniliformis, Spirillum minus

Direct joint penetration, usually of the small joints of the hands

The elderly

Patients with severe joint trauma or serious disease (eg, immunosuppression, hemodialysis, SLE, RA, diabetes, cancer)

Staphylococci (particularly in RA), gram-negative bacteria (eg, Enterobacter, P. aeruginosa, Serratia marcescens), Salmonella sp (particularly in SLE*)

Urinary tract, skin

Patients with polyarticular infections

Patients with joint penetration (caused by injury, arthrocentesis, or arthrotomy), contiguous infection, diabetes, or cancer

Streptococci

Anaerobes (eg, Propionibacterium acnes, Peptostreptococcus magnus, Fusobacterium sp, Clostridium sp, Bacteroides sp); often as mixed infections with facultative or aerobic bacteria such as S. aureus, Staphylococcus epidermidis, E. coli

Pharyngitis, cellulitis, GI and GU infections

Abdomen, genitals, odontogenic infections, sinuses, ischemic limbs, decubitus ulcers

HIV-infected patients

S. aureus, streptococci, Salmonella sp, mycobacteria

Skin, mucous membranes, catheters

Injection drug use, indwelling vascular catheters (eg, for hemodialysis, apheresis, or parenteral nutrition)

Gram-negative bacteria, S. aureus, streptococci

Bacteremia

*Signs of inflammation can be blunted, so physicians need to have a lower threshold for aspiration and culture; serious conditions (eg, immunosuppression, hemodialysis, SLE, RA, diabetes, cancer) may increase risk of unusual infections (eg, fungal, mycobacterial).

Symptoms and Signs

Over a few hours to a few days, patients develop moderate to severe joint pain, warmth, tenderness, effusion, restricted active and passive motion, and sometimes redness. Systemic symptoms may be minimal or absent.

Infants and children may present with limited spontaneous movement of a limb (pseudoparalysis), irritability, feeding disturbances, and a high, low-grade, or no fever.

Gonococcal arthritis

Gonococcal arthritis can cause a distinctive dermatitis-polyarthritis-tenosynovitis syndrome.

Classic manifestations are fever (for 5 to 7 days); multiple skin lesions (petechiae, papules, pustules, hemorrhagic vesicles or bullae, necrotic lesions) on mucosal surfaces and on the skin of the trunk, hands, or lower extremities; and migratory arthralgias, arthritis, and tenosynovitis, which evolves into persistent inflammatory arthritis in one or more joints, most often the small joints of the hands, wrists, elbows, knees, and ankles, and rarely the axial skeletal joints.

Symptoms of the original mucosal infection (eg, urethritis, cervicitis) may not be present.

Nongonococcal bacterial arthritis

Nongonococcal bacterial arthritis causes progressive moderate to severe joint pain that is markedly worsened by movement or palpation. Most infected joints are swollen, red, and warm. Fever is absent or low grade in up to 50% of patients; only 20% of patients report a shaking chill. Virulent organisms (eg, S. aureus, Pseudomonas aeruginosa) generally cause a more fulminant arthritis, whereas less virulent organisms (eg, coagulase-negative staphylococci, Propionibacterium acnes) cause a less fulminant arthritis.

In 80% of adults, nongonococcal bacterial arthritis is monarticular and usually occurs in a peripheral joint: knee, hip, shoulder, wrist, ankle, or elbow. In children, 90% is monarticular: knee (39%), hip (26%), and ankle (13%).

Polyarticular involvement is somewhat more common among patients who are immunosuppressed, who have an underlying chronic arthritis (eg, RA, osteoarthritis), or who have a streptococcal infection. In injection drug users and patients with indwelling vascular catheters, axial joints (eg, sternoclavicular, costochondral, hip, shoulder, vertebral, symphysis pubis, sacroiliac) are often involved. H. influenza may cause a dermatitis-arthritis syndrome similar to gonococcal infection.

Infectious arthritis secondary to bite wounds

Infection due to human, dog, or cat bites usually develops within 48 h.

Rat bites cause systemic symptoms such as fever, rash, and joint pain or true arthritis with regional adenopathy within about 2 to 10 days.

Viral infectious arthritis

Viral infectious arthritis sometimes causes symptoms similar to acute nongonococcal bacterial arthritis and is more likely to be polyarticular than bacterial arthritis.

Borrelia burgdorferi arthritis

Patients with B. burgdorferi arthritis may have other symptoms of Lyme disease (see Lyme Disease : Symptoms and Signs) or present only with acute monarthritis or oligoarthritis.

A polyarticular RA-like syndrome is distinctly unusual and more likely to be from another diagnosis.

Diagnosis

  • Arthrocentesis with synovial fluid examination and culture

  • Blood culture

  • Sometimes imaging studies

  • Usually CBC and ESR (or C-reactive protein)

Infectious arthritis is suspected in patients with acute monarticular arthritis and in patients with other combinations of symptoms characteristic of particular infectious arthritis syndromes (eg, migratory polyarthritis, tenosynovitis, and skin lesions typical of disseminated gonococcal infection; erythema migrans or other symptoms and signs of Lyme disease—see Lyme Disease : Symptoms and Signs).

Even mild monarticular joint symptoms should arouse suspicion in patients taking immunosuppressive therapy (eg, corticosteroids, TNF inhibitors) with risk factors (eg, RA), a prosthetic joint, or an extra-articular infection capable of spreading to a joint (eg, genital gonococcal infection, pneumonia, bacteremia, any anaerobic infection).

Pearls & Pitfalls

  • Do an arthrocentesis and culture synovial fluid to exclude joint infection in patients with joint effusion and findings compatible with bacterial infectious arthritis, even if a known joint disorder (eg, RA) seems like a more likely cause.

General arthritis

Synovial fluid examination is the cornerstone of diagnosis. Fluid is examined grossly and sent for cell count and differential, Gram stain, aerobic and anaerobic culture, and crystals. Foul-smelling synovial fluid suggests anaerobic infection. Fluid from an acutely infected joint usually reveals a WBC count > 20,000/μL (sometimes > 100,000/μL) consisting of > 95% PMNs. WBC counts tend to be higher in nongonococcal bacterial than in gonococcal infectious arthritis. WBC counts may also be lower in early or partially treated infections. Gram stain reveals organisms in only 50 to 75% of joints with acute bacterial arthritis, most often with staphylococci. If positive, Gram stain is suggestive, but cultures are definitive. The presence of crystals does not exclude coexisting infectious arthritis. Sometimes synovial fluid analysis cannot differentiate between infectious and other inflammatory synovial fluid. If differentiation is impossible by clinical means or synovial fluid examination, infectious arthritis is assumed, pending culture results.

Blood tests, such as blood cultures, CBC, and ESR (or C-reactive protein), are usually obtained. However, normal results do not exclude infection. Likewise, WBC count, ESR, or C-reactive protein may be increased in noninfectious joint inflammation (including gout) as well as infectious joint inflammation. The serum urate level should not be used to diagnose or exclude gout as the cause of the arthritis because the level can be normal or even low.

Plain x-rays of the involved joint are not diagnostic of acute infection but can exclude other conditions under consideration (eg, fractures). Abnormalities in early acute bacterial arthritis are limited to soft-tissue swelling and signs of synovial effusions. After 10 to 14 days of untreated bacterial infection, destructive changes of joint space narrowing (reflecting cartilage destruction) and erosions or foci of subchondral osteomyelitis may appear. Gas visible within the joints suggests infection with Escherichia coli or anaerobes.

MRI is considered if the joint is not easily accessible for examination and aspiration (eg, an axial joint). MRI or ultrasonography can identify sites of effusion or abscess that can be aspirated or drained for both diagnosis and therapy. MRI can provide early suggestion of associated osteomyelitis. Bone scans using technetium-99m can be falsely negative in infectious arthritis. Also, because they show increased uptake with increased blood flow in inflamed synovial membranes and in metabolically active bone, they can be falsely positive in noninfectious inflammatory arthritis such as gout. Nuclear imaging and MRI do not distinguish infection from crystal-induced arthritis.

Gonococcal arthritis

If gonococcal arthritis is suspected, blood and synovial fluid samples should be immediately plated on nonselective chocolate agar, and specimens from the urethra, endocervix, rectum, and pharynx should be plated on selective Thayer-Martin medium. The nucleic acid–based tests often used to diagnose genital gonococcal infection are done on synovial fluid only in specialized laboratories. Genital cultures or DNA testing is also done. Blood cultures may be positive during the first week and may assist in microbiologic diagnosis.

Synovial fluid cultures from joints with frank purulent arthritis are usually positive, and fluid from skin lesions may be positive. If disseminated gonococcal infection is suspected based on clinical criteria, it is assumed to be present even if all gonococcal cultures are negative. Clinical response to antibiotics (anticipated within 5 to 7 days) can help confirm the diagnosis.

Prognosis

Acute nongonococcal bacterial arthritis can destroy articular cartilage, permanently damaging the joint within hours or days.

Gonococcal arthritis does not usually damage joints permanently. Factors that increase susceptibility to infectious arthritis may also increase disease severity. In patients with RA, functional outcome is particularly poor, and the mortality rate is increased.

Treatment

  • IV antibiotics

  • Drainage of pus from infected joints (for acute nongonococcal bacterial arthritis or any septic arthritis with persistent effusion)

Antibiotic therapy

Initial antibiotic selection is directed at the most likely pathogens. The regimen is adjusted based on the results of culture and susceptibility testing.

Gonococcal arthritis is treated with ceftriaxone 1 g IV once/day until at least 24 h after symptoms and signs resolve, followed by cefixime 400 mg po bid for 7 days. Fluoroquinolones, such as ciprofloxacin 750 mg po bid, may be used in patients who are allergic to beta-lactams if the isolated organism is proven susceptible. Joint drainage and debridement may be unnecessary. Coexisting genital infection with C. trachomatis is also treated, often with doxycycline 100 mg po bid for 7 days or azithromycin 1 g orally once; sexual contacts of the patient are treated as necessary (see Sex partners).

If nongonococcal gram-positive infection is suspected by Gram stain in an adult , the empiric choice is one of the following:

  • A semisynthetic penicillin (eg, nafcillin 2 g IV q 4 h)

  • A cephalosporin (eg, cefazolin 2 g IV q 8 h)

  • Vancomycin 1 g IV q 12 h (if methicillin resistance is common among local community isolates of S. aureus)

If gram-negative infection is suspected (eg, in patients with immunosuppression or serious comorbid disorders, injection drug use, a recent infection with antibiotic use, or an indwelling vascular catheter), empiric treatment includes a parenteral 3rd-generation cephalosporin with antipseudomonal activity (eg, ceftazidime 2 g IV q 8 h) and, if infection is severe, an aminoglycoside.

Neonates should be treated initially with an antibiotic that covers gram-positive infection (eg, nafcillin, vancomycin) plus an antibiotic that covers gram-negative infection (eg, gentamicin or a 3rd-generation cephalosporin such as cefotaxime).

Children > 3 mo of age should be treated initially similarly to adults.

Parenteral antibiotics are continued until clinical improvement is clear (usually 2 to 4 wk), and oral antibiotics should be given at high doses for another 2 to 6 wk according to the clinical response.

Infections caused by streptococci and Haemophilus are usually eradicated after 2 wk of oral antibiotics after IV treatment.

Staphylococcal infections are treated with antibiotics for at least 3 wk and often 6 wk or longer, especially in patients with prior arthritis or whose diagnosis was delayed.

Other therapies

In addition to antibiotics, acute nongonococcal bacterial arthritis requires large-bore needle aspiration of intra-articular pus at least once/day, or tidal irrigation lavage, arthroscopic lavage, or arthrotomy for debridement. Infected RA joints should generally undergo early and aggressive surgical debridement and drainage.

For gonococcal arthritis with persistent effusion, pus is aspirated and drainage may need to be repeated as necessary. Acute bacterial arthritis requires joint splinting for the first few days to reduce pain, followed by passive and active range-of-motion exercises to limit contractures, with muscle strengthening as soon as it can be tolerated. NSAIDs can help decrease pain and inflammation. Intra-articular corticosteroids should be avoided during the acute infection.

Viral arthritis and arthritis secondary to bite wounds

Viral arthritis is treated supportively.

Bite wounds are treated with antibiotics and surgical drainage as necessary (see Human and Mammal Bites : Treatment).

Key Points

  • Gonococcal arthritis manifests with less severe acute inflammation than does acute nongonococcal bacterial arthritis.

  • Suspect infectious arthritis if patients have acute monarticular arthritis, particularly patients at risk, or findings suggesting other particular infectious arthritis syndromes.

  • Test and culture synovial fluid to confirm or exclude the diagnosis; x-rays and routine laboratory studies are usually of little help.

  • Diagnose and treat infectious arthritis, particularly nongonococcal bacterial arthritis, as soon as possible.

  • Direct initial antibiotic therapy at pathogens suspected based on clinical and Gram stain findings.

Resources In This Article

Drugs Mentioned In This Article

  • Drug Name
    Select Trade
  • PERIOSTAT, VIBRAMYCIN
  • FORTAZ, TAZICEF
  • ROCEPHIN
  • GENOPTIC
  • ZITHROMAX
  • VANCOCIN
  • NALLPEN IN PLASTIC CONTAINER
  • CILOXAN, CIPRO
  • CLAFORAN
  • ANCEF, KEFZOL
  • SUPRAX

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