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Dehydroepiandrosterone (DHEA)

By Ara DerMarderosian, PhD, University of the Sciences in Philadelphia

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Dehydroepiandrosterone (DHEA) is a steroid produced by the adrenal gland and is a precursor of estrogens and androgens. Effects on the body are similar to those of testosterone . DHEA can also be synthesized from precursors in the wild Mexican yam; this form is the most commonly available. However, consumption of wild yam is not recommended as a supplement as the body is unable to convert the precursors to DHEA.

Claims

DHEA supplements are said to improve mood, energy, sense of well-being, and the ability to function well under stress. They are also said to improve athletic performance, stimulate the immune system, deepen nightly sleep, lower cholesterol levels, decrease body fat, build muscles, reverse aging, improve brain function in patients with Alzheimer disease, increase libido, and decrease symptoms of systemic lupus erythematosus.

Evidence

The medicinal claims of DHEA have not been fully supported by the evidence. In addition, DHEA is banned by numerous professional sports organizations as it is classified as a "prohormone."

DHEA levels are known to naturally decrease with age and therefore people in search of the unattainable fountain of youth have turned to DHEA supplementation as a possible solution to ailments associated with age. Studies have been reported showing both positive and negative results. More thorough studies are warranted not only with aging but with all clinical health conditions.

A 2013 meta-analysis of data collected from studying 1353 elderly men in a number of trials indicated that DHEA supplementation was associated with a reduction of fat mass; however, no effect was observed for numerous other clinical parameters, including lipid and glycemic metabolism, bone health, sexual function, or quality of life (1). A similar analysis was performed in women with adrenal insufficiency and indicated that DHEA supplementation may improve the quality of life and symptoms of depression, while having no effect on anxiety and sexual well-being (2).

Adverse effects

Adverse effects are unclear. There are theoretical risks of gynecomastia in men, hirsutism in women, acne, and stimulation of prostate and breast cancer. There is a case report of mania and one of seizure.

Drug interactions

None are well documented.

Dehydroepiandrosterone (DHEA) references

  • Corona G, Rastrelli G, Giagulli V, et al. Dehydroepiandrosterone supplementation in elderly men: a meta-analysis study of placebo controlled trials. J Clin Endocrinol Metab 98(9):3615-3626, 2013.

  • Alkatib AA, Cosma M, Elamin MB, et al. A systematic review and meta-analysis of randomized placebo-controlled trials of DHEA treatment effects on quality of life in women with adrenal insufficiency. J Clin Endocrinol Metab 94(10):3676-3781, 2009.

Drugs Mentioned In This Article

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  • DELATESTRYL

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