Merck Manual

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Mark A. Farber

, MD, FACS, University of North Carolina;

Federico E Parodi

, MD, University of North Carolina School of Medicine

Last full review/revision Nov 2020| Content last modified Nov 2020
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Topic Resources

Aortitis is inflammation of the aorta, sometimes causing aneurysm or occlusion.

Aortitis is rare, but potentially life threatening. Its reported incidence is 1 to 3 per one million/year.

Aortitis is caused by

It is also a feature of Cogan syndrome (inflammatory keratitis, vestibular and auditory dysfunction, and aortitis).

Inflammation usually involves all layers of the aorta (intima, media, adventitia) and may lead to occlusion of the aorta or its branches or weakening of the arterial wall, resulting in an aortic aneurysm.

Pathogenesis, symptoms and signs, diagnosis, and treatment differ by etiology.

However, the general principle for treatment is to treat the underlying disorder.

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