A colonic diverticulum is a saclike pouch of colonic mucosa and submucosa that protrudes through the muscular layer of the colon; because it does not contain all layers of the bowel, it is considered a pseudodiverticulum (see also Definition of Diverticular Disease Definition of Diverticular Disease Diverticula are saclike mucosal pouches that protrude from a tubular structure. True diverticula of the gastrointestinal (GI) tract contain all layers of the GI wall. Esophageal diverticula... read more ).
Although diverticula can occur anywhere in the large bowel, they usually occur in the sigmoid portion of the colon. They rarely occur below the peritoneal reflection and involve the rectum. Diverticula vary in diameter but typically are 3 to 10 mm in size. Giant diverticula, which are extremely rare, are defined as diverticula > 4 cm in diameter; sizes up to 25 cm have been reported. People who have colonic diverticulosis usually have several diverticula.
Diverticula, Diverticulosis, and Diverticulitis (https://www.youtube.com/watch?v=TL9_WKuNfu0) by Osmosis (https://open.osmosis.org/) is licensed under CC-BY-SA 4.0 (https://creativecommons.org/licenses/by-sa/4.0/).
Diverticulosis becomes more common with increasing age; it is present in about 75% of people > 80 years.
Etiology of Colonic Diverticulosis
The etiology of colonic diverticulosis is multifactorial and not entirely known. Several studies have suggested a correlation between symptomatic diverticular disease and environmental factors such as a diet low in fiber or high in red meat, sedentary lifestyle, obesity, smoking, and use of nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, acetaminophen, corticosteroids, and opioids. Other possible risk factors include heritable factors and alterations in the colonic wall structure and motility (1 Diverticular bleeding reference Colonic diverticulosis is the presence of one or more diverticula in the colon. Most diverticula are asymptomatic, but some become inflamed or bleed. Diagnosis is by colonoscopy, capsule endoscopy... read more 
, 2 Diverticular bleeding reference Colonic diverticulosis is the presence of one or more diverticula in the colon. Most diverticula are asymptomatic, but some become inflamed or bleed. Diagnosis is by colonoscopy, capsule endoscopy... read more ). Diverticula are possibly caused by an increase in intraluminal pressure, which leads to mucosal extrusion through the weakest points of the muscular layer of the bowel—areas adjacent to intramural blood vessels.
The etiology of giant diverticula is unclear. One theory is that a narrow neck-opening leads to a ball-valve effect with intermittent obstruction of the opening causing the diverticulum to enlarge. A very large giant diverticulum is often a true perforation of a smaller diverticulum that was contained and walled off and became lined mostly by granulation tissue.
Symptoms and Signs of Colonic Diverticulosis
Most (80%) patients with diverticulosis are asymptomatic or have only intermittent constipation. About 20% become symptomatic with pain or bleeding when inflammatory or hemorrhagic complications develop.
Patients with diverticulosis sometimes develop nonspecific gastrointestinal (GI) symptoms, including abdominal pain, bloating, constipation, diarrhea, and passage of mucus from the rectum. This constellation is sometimes referred to as symptomatic uncomplicated diverticular disease (SUDD) Symptomatic Uncomplicated Diverticular Disease (SUDD) Colonic diverticulosis is the presence of one or more diverticula in the colon. Most diverticula are asymptomatic, but some become inflamed or bleed. Diagnosis is by colonoscopy, capsule endoscopy... read more . However, some specialists believe these symptoms are due to another disorder (eg, irritable bowel syndrome Irritable Bowel Syndrome (IBS) Irritable bowel syndrome is characterized by recurrent abdominal discomfort or pain with at least two of the following characteristics: relation to defecation, association with a change in frequency... read more ), and the presence of diverticula is coincidental rather than causal.
Complications of diverticulosis
Complications of colonic diverticular disease are more common among people who smoke, are obese, have HIV infection, or use NSAIDs or are undergoing cancer chemotherapy. Complications occur in 15 to 20% of patients and include
Diverticular bleeding
Segmental colitis associated with diverticular disease (SCAD) Segmental Colitis Associated With Diverticulosis (SCAD) Diverticulitis is inflammation with or without infection of a diverticulum, which can result in phlegmon of the bowel wall, peritonitis, perforation, fistula, or abscess. The primary symptom... read more
Diverticulitis Colonic Diverticulitis Diverticulitis is inflammation with or without infection of a diverticulum, which can result in phlegmon of the bowel wall, peritonitis, perforation, fistula, or abscess. The primary symptom... read more is painful inflammation of a diverticulum. It may be uncomplicated or complicated.
Diverticular bleeding Diverticular bleeding Colonic diverticulosis is the presence of one or more diverticula in the colon. Most diverticula are asymptomatic, but some become inflamed or bleed. Diagnosis is by colonoscopy, capsule endoscopy... read more occurs in 10 to 15% of patients with diverticulosis.
Segmental colitis associated with diverticular disease (SCAD) Segmental Colitis Associated With Diverticulosis (SCAD) Diverticulitis is inflammation with or without infection of a diverticulum, which can result in phlegmon of the bowel wall, peritonitis, perforation, fistula, or abscess. The primary symptom... read more refers to manifestations of colitis (eg, hematochezia, abdominal pain, diarrhea) that develop in a few (1%) patients with diverticulosis. The degree to which the diverticulosis is causal is unclear.
Diverticular bleeding
Diverticular bleeding is the most common cause (up to 50%) of brisk lower GI bleeding Overview of Gastrointestinal Bleeding Gastrointestinal (GI) bleeding can originate anywhere from the mouth to the anus and can be overt or occult. The manifestations depend on the location and rate of bleeding. (See also Varices... read more 
in adults. A study showed that the cumulative incidence of lower GI bleeding from diverticulosis was about 2% at 5 years and 10% at 10 years (1 Diverticular bleeding reference Colonic diverticulosis is the presence of one or more diverticula in the colon. Most diverticula are asymptomatic, but some become inflamed or bleed. Diagnosis is by colonoscopy, capsule endoscopy... read more ).
The pathophysiology of diverticular bleeding is unknown, but several mechanisms are hypothesized, including
Local trauma from impacted feces in a diverticulum that can erode the adjacent vessel
Enlargement of the diverticulum that can stretch (and ultimately tear) the vessel
NSAIDs have been reported to increase the risk of hemorrhage.
Although most diverticula are in the distal (left) colon, half of diverticular bleeding occurs from diverticula in the proximal (right) colon. Patients with pancolonic diverticulosis have a higher incidence of bleeding.
Diverticular bleeding manifests as painless hematochezia. Because the bleeding vessel is an arteriole, the amount of blood loss is usually moderate to severe. Fresh blood or maroon-colored stool is the typical manifestation; rarely, right-sided diverticular bleeding can manifest as melena. Diverticular bleeding usually occurs without concomitant diverticulitis.
The majority (75%) of episodes of bleeding cease spontaneously. The remainder require intervention Treatment of diverticular bleeding Colonic diverticulosis is the presence of one or more diverticula in the colon. Most diverticula are asymptomatic, but some become inflamed or bleed. Diagnosis is by colonoscopy, capsule endoscopy... read more , typically endoscopic (see also the American College of Gastroenterology's 2016 practice guidelines on management of patients with acute lower gastrointestinal bleeding).
Patients who have had a diverticular bleeding episode have an increased risk of rebleeding. After a second episode of diverticular bleeding, the risk of rebleeding is 50%.
Diverticular bleeding reference
1. Niikura R, Nagata N, Shimbo T, et al: Natural history of bleeding risk in colonic diverticulosis patients: A long-term colonoscopy-based cohort study. Aliment Pharmacol Ther 41(9):888–894, 2015. doi: 10.1111/apt.13148
Diagnosis of Colonic Diverticulosis
Usually colonoscopy or CT
Asymptomatic diverticula are usually found incidentally during colonoscopy, capsule endoscopy, barium enema, CT, or MRI.
Lower GI bleeding due to diverticulosis is suspected when painless rectal bleeding develops, particularly in an older patient or in a patient who has a history of diverticular disease. Evaluation of lower GI bleeding Testing Gastrointestinal (GI) bleeding can originate anywhere from the mouth to the anus and can be overt or occult. The manifestations depend on the location and rate of bleeding. (See also Varices... read more typically includes colonoscopy, which can be done after rapid colonic preparation: 4 to 6 L of polyethylene glycol solution delivered orally, ideally via a nasogastric tube, and given over 3 to 4 hours until the rectal effluent is clear of blood and stool. If the source cannot be seen with colonoscopy and ongoing bleeding is sufficiently rapid (> 0.5 to 1 mL/minute), CT angiography or radionuclide imaging may localize the source.
Treatment of Colonic Diverticulosis
No treatment for asymptomatic diverticulosis
Management of specific symptoms
Diverticular bleeding treated as a lower GI bleed
Asymptomatic diverticulosis requires no treatment or dietary changes. There is no association between consumption of nuts, seeds, corn, or popcorn and diverticulitis, diverticular hemorrhage, or uncomplicated diverticulosis, and avoidance of these foods is no longer recommended. NSAIDs and opioid analgesics may increase the risk of diverticular perforation and bleeding, therefore these drugs should be used only with appropriate caution and after extensive discussion with the patient about the risks.
For diverticulosis with nonspecific GI symptoms, treatment is aimed at reducing spasm of a segment of colon. A high-fiber diet is often recommended and may be supplemented by psyllium seed preparations or bran together with adequate fluid intake. However, the role of fiber in the treatment of diverticulosis is limited. In general, data are inadequate to confirm beneficial effects of fiber. Bulk-forming laxatives should be considered for people with constipation (see also 2019 guidelines for diagnosis and management of diverticular disease from the National Institute for Health and Care Excellence). Antispasmodics (eg, belladonna) are not of benefit and may cause adverse effects. Low-fiber diets are not helpful. Surgery is unwarranted for uncomplicated disease except for giant diverticula.
Treatment of diverticular bleeding
Diverticular bleeding stops spontaneously in 75% of patients. Initial management is as for lower GI bleeding Treatment Gastrointestinal (GI) bleeding can originate anywhere from the mouth to the anus and can be overt or occult. The manifestations depend on the location and rate of bleeding. (See also Varices... read more . Treatment of diverticular bleeding is often given during the diagnostic procedure. However, several reports have shown that during the colonoscopy stigmata of recent hemorrhage (active bleeding, adherent clot, and visible vessel) are identified in only 8 to 15% of patients (1 Treatment references Colonic diverticulosis is the presence of one or more diverticula in the colon. Most diverticula are asymptomatic, but some become inflamed or bleed. Diagnosis is by colonoscopy, capsule endoscopy... read more ). Colonoscopic identification of stigmata of recent hemorrhage allows for endoscopic options to control bleeding, including epinephrine injection, application of endoclips or fibrin sealant, heater probe or bipolar coagulation, and band ligation. Data suggest that both early and late recurring bleeding rates are lower in patients with definitive colonic diverticular bleeding that is treated endoscopically than in those with presumptive colonic diverticular bleeding that is treated conservatively (1 Treatment references Colonic diverticulosis is the presence of one or more diverticula in the colon. Most diverticula are asymptomatic, but some become inflamed or bleed. Diagnosis is by colonoscopy, capsule endoscopy... read more ).
Angiography can help with diagnosis of the source of bleeding and treatment of ongoing bleeding. During angiography, a number of techniques can be used to control the bleeding, particularly embolization and, less often, vasopressin injection. Embolization is successful about 80% of the time. Angiographic complications of bowel ischemia or infarction are less common (< 5%) with current super-selective catheterization techniques.
Surgery is rarely needed but is recommended for patients who have had multiple or persistent episodes of diverticular bleeding refractory to therapy or who have hemodynamic instability despite aggressive resuscitation.
If angiography or surgery is being considered, identifying the specific bleeding diverticulum endoscopically or using a nuclear medicine study during active bleeding gives direction to the interventional radiologist and may limit the size of a potential surgical resection. When the bleeding site is known, the need for subtotal colectomy (with its associated higher morbidity and mortality) is markedly reduced because a hemicolectomy or segmental colectomy may be done instead. However, patients who have continued and life-threatening hemorrhage and no identifiable bleeding diverticulum may require a subtotal colectomy. [Patients with diverticular bleeding who have an unclear localization of the bleeding site have a mortality rate of 43% after colonic surgery, whereas patients who have a defined localization of the bleeding site have a mortality rate of 7% after surgery (2 Treatment references Colonic diverticulosis is the presence of one or more diverticula in the colon. Most diverticula are asymptomatic, but some become inflamed or bleed. Diagnosis is by colonoscopy, capsule endoscopy... read more ).
Treatment references
1. Gobinet-Suguro M, Nagata N, Kobayashi K, et al: Treatment strategies for reducing early and late recurrence of colonic diverticular bleeding based on stigmata of recent hemorrhage: A large multicenter study. Gastrointest Endosc 95(6):1210–1222.e12, 2022. doi: 10.1016/j.gie.2021.12.023
2. Schultz JK, Azhar N, Binda GA, et al: European Society of Coloproctology: Guidelines for the management of diverticular disease of the colon. Colorectal Dis 22 (supplement 2):S5–S28, 2020. doi: 10.1111/codi.15140
Key Points
Colonic diverticula are saclike mucosal pouches that protrude from the colon.
Diverticulosis is increasingly common with age; it is present in about 75% of people > 80 years.
Diverticulosis is usually asymptomatic, but about 20% of patients develop symptoms and/or complications, including inflammation (diverticulitis Colonic Diverticulitis Diverticulitis is inflammation with or without infection of a diverticulum, which can result in phlegmon of the bowel wall, peritonitis, perforation, fistula, or abscess. The primary symptom... read more
) and lower gastrointestinal bleeding.Asymptomatic diverticulosis requires no treatment.
Diverticular bleeding stops spontaneously in about 75% of patients; control the remainder during colonoscopy or angiography, or rarely with surgery.
More Information
The following English-language resources may be useful. Please note that THE MANUAL is not responsible for the content of these resources.
American College of Gastroenterology: Practice guidelines on management of adults with acute lower GI bleeding (2016)
National Institute for Health and Care Excellence (NICE): Guidelines for diagnosis and management of diverticular disease (2019)
Symptomatic Uncomplicated Diverticular Disease (SUDD)
in the absence of overt colitis or diverticulitis Colonic Diverticulitis Diverticulitis is inflammation with or without infection of a diverticulum, which can result in phlegmon of the bowel wall, peritonitis, perforation, fistula, or abscess. The primary symptom... read more .Some medical authorities consider symptomatic uncomplicated diverticular disease (SUDD) to be a form of irritable bowel syndrome Irritable Bowel Syndrome (IBS) Irritable bowel syndrome is characterized by recurrent abdominal discomfort or pain with at least two of the following characteristics: relation to defecation, association with a change in frequency... read more that occurs coincidentally in patients with diverticulosis.
Patients with SUDD have left lower quadrant abdominal pain with bloating, constipation, diarrhea, or passage of mucus from the rectum. In general, patients have a very low incidence of complications.
Diagnosis of SUDD is difficult because the difference between irritable bowel syndrome and SUDD is not well-defined.
There are no strong, evidence-based data regarding treatment of patients with SUDD (1 General references Colonic diverticulosis is the presence of one or more diverticula in the colon. Most diverticula are asymptomatic, but some become inflamed or bleed. Diagnosis is by colonoscopy, capsule endoscopy... read more , 2 General references Colonic diverticulosis is the presence of one or more diverticula in the colon. Most diverticula are asymptomatic, but some become inflamed or bleed. Diagnosis is by colonoscopy, capsule endoscopy... read more ).
General references
1. Elisei W, Tursi A: Recent advances in the treatment of colonic diverticular disease and prevention of acute diverticulitis. Ann Gastroenterol 29(1):24–32, 2016. PMID: 26752946
2. Boynton W, Floch M: New strategies for the management of diverticular disease: Insights for the clinician. Therap Adv Gastroenterol 6(3):205–213, 2013. doi: 10.1177/1756283X13478679
Drugs Mentioned In This Article
| Drug Name | Select Trade |
|---|---|
aspirin |
Anacin Adult Low Strength, Aspergum, Aspir-Low, Aspirtab , Aspir-Trin , Bayer Advanced Aspirin, Bayer Aspirin, Bayer Aspirin Extra Strength, Bayer Aspirin Plus, Bayer Aspirin Regimen, Bayer Children's Aspirin, Bayer Extra Strength, Bayer Extra Strength Plus, Bayer Genuine Aspirin, Bayer Low Dose Aspirin Regimen, Bayer Womens Aspirin , BeneHealth Aspirin, Bufferin, Bufferin Extra Strength, Bufferin Low Dose, DURLAZA, Easprin , Ecotrin, Ecotrin Low Strength, Genacote, Halfprin, MiniPrin, St. Joseph Adult Low Strength, St. Joseph Aspirin, VAZALORE, Zero Order Release Aspirin, ZORprin |
acetaminophen |
7T Gummy ES, Acephen, Aceta, Actamin, Adult Pain Relief, Anacin Aspirin Free, Apra, Children's Acetaminophen, Children's Pain & Fever , Comtrex Sore Throat Relief, ED-APAP, ElixSure Fever/Pain, Feverall, Genapap, Genebs, Goody's Back & Body Pain, Infantaire, Infants' Acetaminophen, LIQUID PAIN RELIEF, Little Fevers, Little Remedies Infant Fever + Pain Reliever, Mapap, Mapap Arthritis Pain, Mapap Infants, Mapap Junior, M-PAP, Nortemp, Ofirmev, Pain & Fever , Pain and Fever , PAIN RELIEF , PAIN RELIEF Extra Strength, Panadol, PediaCare Children's Fever Reducer/Pain Reliever, PediaCare Children's Smooth Metls Fever Reducer/Pain Reliever, PediaCare Infant's Fever Reducer/Pain Reliever, Pediaphen, PHARBETOL, Plus PHARMA, Q-Pap, Q-Pap Extra Strength, Silapap, Triaminic Fever Reducer and Pain Reliever, Triaminic Infant Fever Reducer and Pain Reliever, Tylenol, Tylenol 8 Hour, Tylenol 8 Hour Arthritis Pain, Tylenol 8 Hour Muscle Aches & Pain, Tylenol Arthritis Pain, Tylenol Children's, Tylenol Children's Pain+Fever, Tylenol CrushableTablet, Tylenol Extra Strength, Tylenol Infants', Tylenol Infants Pain + Fever, Tylenol Junior Strength, Tylenol Pain + Fever, Tylenol Regular Strength, Tylenol Sore Throat, XS No Aspirin, XS Pain Reliever |
polyethylene glycol |
GaviLax, GIALAX , GlycoLax, Healthylax, MiraLax, Visine Dry Eye Relief, Vita Health |
psyllium |
Fiber Therapy, GenFiber , Geri-Mucil, Hydrocil , Konsyl, Metamucil, Metamucil MultiHealth, Mucilin , Natural Fiber Laxative, Natural Fiber Therapy, Reguloid |
epinephrine |
Adrenaclick, Adrenalin, Auvi-Q, Epifrin, EpiPen, Epipen Jr , Primatene Mist, SYMJEPI, Twinject |
fibrin sealant |
ARTISS, Raplixa, TachoSil Absorbable Fibrin Sealant, TISSEEL |
vasopressin |
Pitressin, Vasostrict |
