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Overview of Sprains and Other Soft-Tissue Injuries


Danielle Campagne

, MD, University of California, San Francisco

Reviewed/Revised Jul 2023
Topic Resources

Sprains are tears in ligaments; strains are tears in muscles. Tears (ruptures) may also occur in tendons.

In addition to sprains, strains, and tendon injuries, musculoskeletal injuries include

Musculoskeletal injuries are common and vary greatly in mechanism, severity, and treatment. The extremities, spine, and pelvis can all be affected.

Musculoskeletal injuries may occur in isolation or as part of multisystem trauma (see Approach to the Trauma Patient Approach to the Trauma Patient Injury is the number one cause of death for people aged 1 to 44. In the US, there were 278,345 trauma deaths in 2020, about 70% of which were accidental. Of intentional injury deaths, more than... read more ). Most musculoskeletal injuries result from blunt trauma, but penetrating trauma can also damage musculoskeletal structures.

Pathophysiology of Sprains and Other Soft-Tissue Injuries

Sprains and strains

Tears in ligaments or muscles may be graded as

  • 1st degree: Minimal (fibers are stretched but intact, or only a few fibers are torn)

  • 2nd degree: Partial (some to almost all fibers are torn)

  • 3rd degree: Complete (all fibers are torn)

Tendon injuries

Tendon tears can be partial or complete.

With complete tears, the motion produced by the detached muscle is usually lost.

Partial tears can result from a single traumatic event (eg, penetrating trauma) or repeated stress (chronically, causing tendinopathy). Motion is often intact, but partial tears may progress to complete tears, particularly when significant or repetitive force is applied.


Many partial tears in ligaments, tendons, or muscles heal spontaneously.

Complete tears often require surgery to restore anatomy and function.

Prognosis and treatment vary greatly depending on the location and severity of the injury.


Serious complications of sprains, strains, and tendon injuries are unusual but may cause permanent limb dysfunction.

Acute complications (associated injuries) include the following:

  • Bleeding: Bleeding (eg, bruising, ecchymoses) accompanies all significant soft-tissue injuries.

  • Vascular injuries: Rarely, what appears to be a severe sprain may be a spontaneously reduced dislocation (eg, of the knee), which may be accompanied by a limb-threatening arterial injury.

  • Nerve injuries: Nerves may be injured when stretched or damaged by associated injuries such as fractures or dislocations or by blunt blows or crush injuries. When nerves are bruised (called neurapraxia), nerve conduction is blocked, but the nerve is not torn. Neurapraxia causes temporary motor and/or sensory deficits; neurologic function returns completely in about 6 to 8 weeks. When nerves are crushed (called axonotmesis), the axon is injured, but the myelin sheath is not. This injury is more severe than neurapraxia. Depending on the extent of the damage, the nerve can regenerate over weeks to years. Torn nerves (called neurotmesis) are usually caused by open injuries. Torn nerves do not heal spontaneously and may have to be repaired surgically.

  • Compartment syndrome Compartment Syndrome Compartment syndrome is increased tissue pressure within a closed fascial space, resulting in tissue ischemia. The earliest symptom is pain out of proportion to the severity of injury. Diagnosis... read more : Rarely, swelling is severe enough to contribute to compartment syndrome. Tissue pressure increases in a closed fascial space, disrupting the vascular supply and reducing tissue perfusion. Untreated compartment syndrome can lead to rhabdomyolysis, hyperkalemia, and infection. It can also cause contractures, sensory deficits, and paralysis. Compartment syndrome threatens limb viability (possibly requiring amputation) and survival.

Long-term complications include the following:

Evaluation of Sprains and Other Soft-Tissue Injuries

  • Evaluation for serious injuries

  • History and physical examination

  • X-rays if needed to check for fractures

Diagnosis of sprains, strains, and tendon injuries should include a thorough history and physical examination, which are often sufficient for diagnosis.

In the emergency department, if the mechanism of injury suggests potentially severe or multiple injuries (as in a high-speed motor vehicle crash or fall from a height), patients are first evaluated from head to toe for serious injuries to all organ systems and, if needed, are resuscitated (see Approach to the Trauma Patient Approach to the Trauma Patient Injury is the number one cause of death for people aged 1 to 44. In the US, there were 278,345 trauma deaths in 2020, about 70% of which were accidental. Of intentional injury deaths, more than... read more ).

Patients should be checked for fractures and dislocations as well as ligament, tendon, and muscle injuries; sometimes parts of this evaluation are deferred until fracture is excluded.

The joint above and below the injured joint should also be examined.


History focuses on the

  • Mechanism of injury

  • Past injuries

  • Timing of pain onset

  • Extent and duration of pain before, during, and after activity

Clinicians should also ask about use of medications (eg, fluoroquinolones, corticosteroids) that increase the risk of tendon tears.

The mechanism (eg, direction and magnitude of force) may suggest the type of injury. However, many patients do not remember or cannot describe the exact mechanism.

If a patient reports a deformity that has resolved before the patient is medically evaluated, the deformity should be assumed to be a true deformity that spontaneously reduced.

A perceived snap or pop at the time of injury may signal a ligament or tendon injury (or a fracture). Serious ligamentous injuries usually cause immediate pain; pain that begins hours to days after the injury suggests minor injury.

Physical examination

Examination includes

  • Vascular and neurologic assessment

  • Inspection for deformity, swelling, ecchymoses, open wounds, and decreased or abnormal motion

  • Palpation for tenderness, crepitus, and gross defects in bone or tendon

  • Examination of the joints above and below the injured area

  • After fracture and dislocation are excluded (clinically or by imaging), stress testing of the affected joints for pain and instability

If muscle spasm and pain limit physical examination (particularly stress testing), examination is sometimes easier after the patient is given a systemic analgesic or local anesthetic. Or the injury can be immobilized until muscle spasm and pain subside, usually for a few days, and then the patient can be reexamined.

Deformity suggests dislocation, subluxation (partial separation of bones in a joint), or fracture.

Swelling commonly indicates a significant musculoskeletal injury but may require several hours to develop. If no swelling occurs within this time, severe ligament disruption is unlikely.

Tenderness accompanies nearly all injuries, and for many patients, palpation anywhere around the injured area causes discomfort. However, a noticeable increase in tenderness in one localized area (point tenderness) suggests a sprain (or fracture). Localized ligamentous tenderness and pain when the joint is stressed are consistent with sprain. With some complete muscle or tendon tears, a defect may be palpable in the affected structure.

Gross joint instability suggests severe ligamentous disruption (or dislocation, which may have spontaneously reduced).

Stress testing Stress testing Sprains of the external (medial and lateral collateral) or internal (anterior and posterior cruciate) ligaments or injuries of the menisci may result from knee trauma. Symptoms include pain... read more is done to evaluate the stability of an injured joint; however, if a fracture is suspected or patients have marked pain, swelling, or spasm, stress testing is deferred until x-rays exclude fracture. Bedside stress testing involves passively opening the joint in a direction usually perpendicular to the normal range of motion (stressing). Because muscle spasm during acutely painful injuries may mask joint instability, the surrounding muscles are relaxed as much as possible, and examinations are begun gently, then repeated, with slightly more force each time. Findings are compared with those for the opposite, normal side but can be limited by their subjective nature.

Findings can help differentiate between 2nd- and 3rd-degree sprains:

  • 2nd-degree sprains: Stress is painful, and joint opening is limited.

  • 3rd-degree sprains: Stress is less painful because the ligament is completely torn and is not being stretched, and joint opening is significant.

If muscle spasm is severe despite use of analgesia or anesthetic injection, the examination should be repeated a few days later, when the spasm has subsided.

Pearls & Pitfalls

  • Stress testing may be less painful with 3rd-degree sprains than with 2nd-degree sprains.

Some partial tendon tears escape initial clinical detection because function appears intact. Any of the following suggests partial tendon tears:

  • Tendon tenderness

  • Pain when the joint is moved through its range of motion

  • Dysfunction

  • Weakness

  • Palpable defects

Partial tendon tears may progress to complete tears if patients continue to use the injured part. If the mechanism of injury or examination suggests a partial tendon injury or if the examination is inconclusive, a splint should be applied to limit motion and thus the potential for further injury. Subsequent examination, occasionally supplemented with MRI, may further delineate the extent of injury.

Attention to certain areas during examination can help detect commonly missed injuries (see table ).


If physical examination is normal in a joint that patients identify as painful, the cause may be referred pain. For example, patients with a sternoclavicular joint injury may feel pain in their shoulder. Thus, clinicians should always examine the joint above and below the injury.


Not all limb injuries require imaging. Many ankle sprains do not require x-rays during the initial evaluation because the probability of finding a fracture that would require a change in treatment is acceptably low; for ankle sprains, explicit, generally accepted criteria for obtaining x-rays (Ottawa ankle rules Imaging Imaging ) can help limit x-rays to patients that are more likely to have a fracture requiring specific treatment. If imaging is needed, plain x-rays are done first.

Plain x-rays, which show primarily bone (and joint effusion secondary to bleeding or occult fracture), may be done to check for dislocations and fractures; plain x-rays do not show direct evidence of sprains but may show abnormal anatomic relationships that suggest sprains or other soft-tissue injuries. X-rays should include at least 2 views taken in different planes (usually anteroposterior and lateral views).

Additional views (eg, oblique) may be done when

  • The evaluation suggests fracture and 2 projections are negative.

  • Additional views are routine for certain joints (eg, a mortise view for evaluating an ankle, an oblique view for evaluating a foot).

  • Certain abnormalities are suspected.

For lateral views of digits, the digit of interest should be separated from the others.

MRI can be done to identify soft-tissue injuries, including ligament, tendon, cartilage, and muscle injuries.

MRI or CT may also be done to check for subtle fractures.

Treatment of Sprains and Other Soft-Tissue Injuries

  • Treatment of associated injuries

  • Reduction as indicated, splinting, and analgesia

  • RICE (rest, ice, compression, and elevation) or PRICE (including protection) as indicated

  • Usually immobilization

  • Sometimes surgery

Initial treatment

Serious associated problems, if present, are treated first. Hemorrhagic shock Treatment of hemorrhagic shock Shock is a state of organ hypoperfusion with resultant cellular dysfunction and death. Mechanisms may involve decreased circulating volume, decreased cardiac output, and vasodilation, sometimes... read more is treated immediately. Injuries to arteries are surgically repaired unless they affect only small arteries with good collateral circulation. Severed nerves are surgically repaired; for neuropraxia and axonotmesis, initial treatment is usually observation, supportive measures, and sometimes physical therapy.

Suspected open fractures or dislocations require

  • Sterile wound dressings

  • Tetanus prophylaxis

  • Broad-spectrum antibiotics (eg, a 2nd-generation cephalosporin plus an aminoglycoside), which should be initiated within one hour of arrival to the emergency department

  • Surgery to irrigate and debride them (and thus prevent infection).

Most moderate and severe injuries, particularly grossly unstable ones, are immobilized immediately by splinting (immobilization with a nonrigid or noncircumferential device) to decrease pain and to prevent further injury to soft tissues by unstable injuries.

After initial treatment, soft-tissue injuries are treated symptomatically and are immobilized as indicated.

Many 3rd-degree sprains and tendon tears require surgical repair.


Patients who have soft-tissue injuries, with or without other musculoskeletal injuries, may benefit from PRICE (protection, rest, ice, compression, elevation), although this practice is not supported by strong evidence.

Protection helps prevent further injury. It may involve limiting the use of an injured part, applying a splint or cast, and/or using crutches.

Rest may prevent further injury and speed healing.

Ice and compression may minimize swelling and pain. Ice is enclosed in a plastic bag or towel and applied intermittently during the first 24 to 48 hours (for 15 to 20 minutes, as often as possible). Injuries can be compressed with a splint, an elastic bandage, or, for certain injuries likely to cause severe swelling, a Jones compression dressing. The Jones dressing is 4 layers; layers 1 (the innermost) and 3 are cotton batting, and layers 2 and 4 are elastic bandages.

Elevating the injured limb above the heart for the first 2 days, ideally in a position that provides an uninterrupted downward path, allows gravity to help drain edema fluid and minimize swelling.

After 48 hours, periodic application of warmth (eg, a heating pad) for 15 to 20 minutes may relieve pain and speed healing.


Immobilization decreases pain and facilitates healing by preventing further injury.

First-degree sprains are immobilized briefly if at all. Early mobilization is best. Mild 2nd-degree sprains are often immobilized with a sling or splint for a few days. Severe 2nd-degree and some 3rd-degree sprains and tendon tears are immobilized for days or weeks, sometimes with a cast. Many 3rd-degree sprains require surgery; usually, immobilization is only adjunctive therapy.

A cast is usually used for injuries that require weeks of immobilization. Rarely, swelling under a cast is severe enough to contribute to compartment syndrome Compartment Syndrome Compartment syndrome is increased tissue pressure within a closed fascial space, resulting in tissue ischemia. The earliest symptom is pain out of proportion to the severity of injury. Diagnosis... read more . If clinicians suspect severe swelling under a cast, the cast (and all padding) is cut open from end to end medially and laterally (bivalved).

Patients with casts should be given written instructions, including the following:

  • Keep the cast dry.

  • Never put an object inside the cast.

  • Inspect the cast’s edges and skin around the cast every day, and report any red or sore areas.

  • Pad any rough edges with soft adhesive tape, cloth, or other soft material to prevent the cast’s edges from injuring the skin.

  • When resting, position the cast carefully, possibly using a small pillow or pad, to prevent the edge from pinching or digging into the skin.

  • Elevate the cast whenever possible to control swelling.

  • Seek medical care immediately if pain persists or the cast feels excessively tight.

  • Seek medical care immediately if an odor emanates from within the cast or if a fever, which may indicate infection, develops.

  • Seek care immediately for progressively worsening pain or any new numbness or weakness.

Good hygiene is important.

A splint (see figure ) can be used to immobilize some stable injuries, including some suspected but unproven fractures, rapidly healing fractures, sprains, and other injuries that require immobilization for several days or less. A splint is noncircumferential; thus, it enables patients to apply ice and to move more than a cast does. Also, it allows for some swelling, so it does not contribute to compartment syndrome. Some injuries that ultimately require casting are immobilized initially with a splint until most of the swelling resolves.

How To Apply Immobilizers

Joint immobilization as acute treatment: Some commonly used techniques

Joint immobilization as acute treatment: Some commonly used techniques

A sling provides some degree of support and limits mobility; it can be useful for injuries that are adversely affected by complete immobilization (eg, for shoulder injuries, which, if completely immobilized, can rapidly lead to adhesive capsulitis [frozen shoulder]).

How To Remove a Cast

A swathe (a piece of cloth or a strap) may be used with a sling to prevent the arm from swinging outward, especially at night. The swathe is wrapped around the back and over the injured part.

Prolonged immobilization (> 3 to 4 weeks for young adults) of a joint can cause stiffness, contractures, and muscle atrophy. These complications may develop rapidly and may be permanent, particularly in older people. Some rapidly healing injuries are best treated with resumption of active motion within the first few days or weeks; such early mobilization may minimize contractures and muscle atrophy, thus accelerating functional recovery. Physical therapists can advise patients as to what they can do during immobilization to maintain as much function as possible (eg, elbow, wrist, and hand range-of-motion exercises if the shoulder is immobilized).

After immobilization, physical therapists can help patients regain or improve range of motion and muscle strength and can provide exercises to strengthen and stabilize the injured joint and thus help prevent recurrence and long-term impairment. Early range-of-motion exercises are important for all patients, especially those age > 40 years. More complications and morbidity can occur for immobilized patients as they age, particularly for anyone > 40 years old.


Many 3rd-degree sprains and tendon tears require surgical repair.

Arthroscopic surgery is sometimes used. This procedure is used most often to repair ligaments or menisci in the knee.

Geriatrics Essentials: Sprains and Other Soft-Tissue Injuries

Older people are predisposed to musculoskeletal injuries in general because of the following:

  • A tendency to fall frequently (eg, due to age-related loss of proprioception, adverse effects of medications or drugs on proprioception or postural reflexes, orthostatic hypotension)

  • Impaired protective reflexes during falls

For any musculoskeletal injury in older people, the goal of treatment is rapid return to activities of daily living.

Immobility (joint immobilization) is more likely to have adverse effects (eg, stiffness, contractures, muscle atrophy) in older people.

Early mobilization and physical therapy are essential to recovery of function.

Coexisting disorders (eg, arthritis) can interfere with recovery.

Key Points

  • Compartment syndrome and injuries that disrupt arterial supply threaten limb viability and may ultimately threaten life; these problems are very rare with sprains and strains.

  • Check for fractures and dislocations, and consider spontaneously reduced dislocations, as well as ligament, tendon, and muscle injuries; sometimes part of this evaluation is deferred until fracture is excluded.

  • Consider referred pain and examine the joints above and below the injured area, particularly if physical findings are normal in a joint that patients identify as painful (eg, shoulder pain in patients with a sternoclavicular joint injury).

  • X-rays are not necessary for many injuries, including ankle sprains.

  • MRI can be used to diagnose soft-tissue injuries.

  • Immediately treat serious associated injuries and splint unstable injuries, and as soon as possible, treat pain.

  • Treat most minor injuries with PRICE (protection, rest, ice, compression, elevation).

  • Provide patients with explicit, written instructions about cast care.

  • Encourage patients, especially older patients, to do the recommended exercises to maintain range of motion and muscle strength.

NOTE: This is the Professional Version. CONSUMERS: View Consumer Version
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