Merck Manual

Please confirm that you are not located inside the Russian Federation

honeypot link



Thomas M. Ruenger

, MD, PhD, Georg-August University of Göttingen, Germany

Reviewed/Revised Jan 2023
Topic Resources

Itching can be very uncomfortable. It is one of the most common reasons people see doctors who specialize in skin disorders (dermatologists).

Itching makes people want to scratch. Scratching temporarily relieves itching but can damage the skin, sometimes resulting in more itching (the itch–scratch cycle) or infection (called a secondary infection). Over time, the skin can become thick and scaly (called lichenification).

Causes of Itching

Itching can result from

  • Skin disorders

  • Disorders of other organs (systemic disorders)

  • Disorders of the nervous system

  • Psychologic disorders

  • Drugs, medications, and chemicals

In many skin and systemic allergic disorders, itching is caused by histamine. Histamine is a chemical in the body that is stored in mast cells. Mast cells Mast Cells One of the body's lines of defense (immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and... read more are part of the immune system Overview of the Immune System The immune system is designed to defend the body against foreign or dangerous invaders. Such invaders include Microorganisms (commonly called germs, such as bacteria, viruses, and fungi) Parasites... read more , and histamine is involved in allergic reactions. When mast cells are stimulated by various allergens (substances that cause an allergic reaction), they release histamine. When histamine is released into the blood, it can cause many symptoms, including itching and inflammation. There are a number of other chemicals in the body that play an important role in itching, such as proteases and cytokines Cytokines One of the body's lines of defense (immune system) involves white blood cells (leukocytes) that travel through the bloodstream and into tissues, searching for and attacking microorganisms and... read more .

Skin disorders

The most common causes of itching are skin disorders:

Systemic (bodywide) disorders

Several systemic disorders can cause itch without any visible changes on the skin (such as a rash). Systemic disorders are less common causes of itch than skin disorders.

Some of the more common systemic causes of itching are

Disorders of the nervous system

Irritation of sensory nerves, for example, when a nerve is compressed, can cause itching localized to the part of the body supplied by that nerve. In contrast, some disorders that affect the nervous system may cause widespread (generalized) itching because itch neurons (one type of nerve cell) are too active or are less inhibited by other neurons. For example, in multiple sclerosis Multiple Sclerosis (MS) In multiple sclerosis, patches of myelin (the substance that covers most nerve fibers) and underlying nerve fibers in the brain, optic nerves, and spinal cord are damaged or destroyed. The cause... read more , nerve conduction is impaired because of an autoimmune process where the immune system attacks the fatty tissue that coats nerve fibers (myelin). This process makes the itch neurons less inhibited and thus more active. Itch that results from nervous system disorders is called neuropathic itch.

Psychologic disorders

Some people who have psychologic disorders may have itching for which no physical cause can be found. This type of itching is called psychogenic itching.

Drugs, medications, and chemicals

Drugs, including medications, and chemicals can cause itching when taken internally or when applied to the skin. Usually the itching is caused by an allergic reaction.

A few drugs, such as morphine and some radiopaque contrast agents Procedure for CT Procedure for CT used when taking certain x-rays, can also cause itching without causing an allergic reaction.

Evaluation of Itching

Not every episode of itching requires immediate evaluation by a doctor. The following information can help people decide whether a doctor's evaluation is needed and help them know what to expect during the evaluation. Most conditions that cause itching are not serious.

Warning signs

The following may indicate that the cause could be serious:

When to see a doctor

People who have weight loss, fatigue, or night sweats should see a doctor as soon as possible.

People who have any of the other warning signs or severe itching should probably see a doctor immediately.

What the doctor does

Doctors ask many questions and look at the skin. Often, a person needs to undress so that the entire skin surface can be checked.

If no clear cause is found after checking the skin, doctors may do a complete physical examination to check for systemic causes. Testing may be necessary to diagnose certain systemic causes and sometimes skin disorders.

If itching is widespread and begins shortly after use of a drug or medication, that drug or medication may be the cause. If itching (usually with a rash) is confined to an area that was in contact with a substance, particularly if the substance is known to cause contact dermatitis Contact Dermatitis Contact dermatitis is skin inflammation caused by direct contact with a particular substance. The rash may be itchy, is confined to a specific area, and often has clearly defined boundaries... read more Contact Dermatitis , that substance is a likely cause. However, allergic causes of widespread itching can be difficult to identify because affected people have usually eaten several different foods and have been exposed to many substances that could cause an allergic reaction before itching develops. Similarly, identifying a drug that is causing the reaction in a person taking several drugs may be difficult. Sometimes the person has been taking the drug or medication causing the reaction for months or even years before a reaction occurs.



Most causes of itching can be diagnosed without testing. If the diagnosis of a skin abnormality is not clear from its appearance and the person's history, removal (biopsy Biopsy Doctors can identify many skin disorders simply by looking at the skin. A full skin examination includes examination of the scalp, nails, and mucous membranes. Sometimes the doctor uses a hand-held... read more Biopsy ) of a skin sample may be necessary so that it can be analyzed.

If the cause of itching seems to be an allergic reaction but the substance causing the allergic reaction is not evident, skin testing may be necessary. In skin testing, substances that can cause allergic reactions on contact are applied to the skin in a patch (called patch testing Skin tests Skin tests ).

If the cause seems not to be an allergic reaction or skin disorder, testing is done based on the person's other symptoms. For example, tests may be done for gallbladder or liver disorders, chronic kidney disease, thyroid disorders, diabetes, or cancer.

Treatment of Itching

  • Skin care

  • Topical treatments

  • Systemic treatments

The most important aspect of treating itch is to address the cause. In addition, other measures can help relieve itching.

Skin care

If itching is caused by dry skin, modifications to basic skin care are often very effective. Dryness is often caused by excessive bathing and washing. Skin care adjustments should include bathing or washing less frequently, using lukewarm instead of hot water, and using less soap.

Excessive rubbing of dry skin should be avoided, and a moisturizing cream should be applied after bathing or washing.

In addition, humidifying dry air (for example, in winter) and not wearing wool clothing can also help.

Topical treatments

Corticosteroid creams, lotions, and ointments should be used only when the skin is inflamed, such as when a person has a rash. They should usually not be used when

  • The skin is infected.

  • An infestation is present.

  • The cause is systemic.

Itch-relieving topical treatments that do not address a specific cause can also be given and include lotions or creams that contain menthol, camphor, pramoxine, or capsaicin. Creams and lotions that contain the antihistamine diphenhydramine or the anesthetic benzocaine are not recommended.

Exposure to ultraviolet light at a doctor's office or in the home (phototherapy Phototherapy Psoriasis is a chronic, recurring disease that causes one or more raised, red patches that have silvery scales and a distinct border between the patch and normal skin. A problem with the immune... read more Phototherapy ) can often help lessen itchy skin disorders. It also often helps relieve itching without a rash (caused by various disorders) when other treatments are unsuccessful.

Systemic treatments

Systemic treatments are medications that are taken internally by mouth or by injection. They are used if itching is widespread or if topical treatments are ineffective.

Antihistamines Antihistamines Allergic reactions (hypersensitivity reactions) are inappropriate responses of the immune system to a normally harmless substance. Usually, allergies cause sneezing, watery and itchy eyes, a... read more Antihistamines , particularly hydroxyzine, are used most often. Some antihistamines, such as cyproheptadine, diphenhydramine, and hydroxyzine, cause drowsiness. They help relieve itching and, when used before bedtime, aid in sleep. Helping people sleep is important because severe itch can affect sleep and thus greatly decrease well being. Because they can cause drowsiness, these medications are usually not given during the day. In addition, they should also be used selectively and carefully by older people because older people are at higher risk of falling. Cetirizine and loratadine cause less drowsiness but rarely can have this effect in older people. Fexofenadine causes less drowsiness but sometimes causes a headache. Doxepin makes people very drowsy and is effective, so it can be taken at bedtime if itching is severe.

Cholestyramine is used to treat itching caused by certain gallbladder or liver disorders. However, cholestyramine has an unpleasant taste, causes constipation, and can decrease absorption of other medications.

Key Points

  • Itching can result from a variety of different causes, and each cause requires different treatment.

  • If the person has no rash or skin abnormalities, the cause may be a systemic disorder, a nerve problem, or a drug or medication reaction.

  • Skin care measures (such as limiting bathing, moisturizing the skin, and humidifying the air) help relieve itching when it is caused by dry skin.

  • Itching can usually be relieved by topical or systemic treatments.

Drugs Mentioned In This Article

Generic Name Select Brand Names
ARYMO ER, Astramorph PF, Avinza, DepoDur, Duramorph PF, Infumorph, Kadian, MITIGO, MORPHABOND, MS Contin, MSIR, Opium Tincture, Oramorph SR, RMS, Roxanol, Roxanol-T
Absorbine Jr, A-R Extreme, Arctic Relief, Arthritis Wonder, Aspercreme, Bengay Cold Therapy, BenGay Pain Relieving, BenGay Ultra Strength, BenGay Vanishing Scent, Bengay Zero Degrees, BiOFREEZE, BIOFREEZE Cold Therapy Pain Relieving, BIOFREEZE Patch, Blue Gel, Cold & Hot Pain Relief Therapy, Eucerin Itch Relief, FLEXALL, Gold Bond, Icy Hot , Luden's, Medicated Topical Body, Mineral Ice, NitroVal Blue, PERFORM Pain Relieving, Therapy Ice, Vicks VapoDrop
Campho-Phenique Cold Sore Treatment for Scab Relief, Dermarest Eczema, New-Skin Poison Ivy, Pramox Gel, Prax, Proctofoam, Sarna Sensitive, Tucks Fast Relief, Vagisil Anti-Itch
Arthricare for Women, Arthritis Pain Relieving, Capsimide, Capzasin-HP, Capzasin-P, Castiva Warming, Circatrix, DermacinRx Circata, DermacinRx Penetral, DiabetAid, Qutenza, Zostrix, Zostrix HP, Zostrix Neuropathy
Aid to Sleep, Alka-Seltzer Plus Allergy, Aller-G-Time , Altaryl, Banophen , Benadryl, Benadryl Allergy, Benadryl Allergy Children's , Benadryl Allergy Dye Free, Benadryl Allergy Kapgel, Benadryl Allergy Quick Dissolve, Benadryl Allergy Ultratab, Benadryl Children's Allergy, Benadryl Children's Allergy Fastmelt, Benadryl Children's Perfect Measure, Benadryl Itch Stopping, Ben-Tann , Compoz Nighttime Sleep Aid, Diphedryl , DIPHEN, Diphen AF , Diphenhist, DiphenMax , Dytan, ElixSure Allergy, Genahist , Geri-Dryl, Hydramine, Itch Relief , M-Dryl, Nighttime Sleep Aid, Nytol, PediaCare Children's Allergy, PediaCare Nighttime Cough, PediaClear Children's Cough, PHARBEDRYL, Q-Dryl, Quenalin , Siladryl Allergy, Silphen , Simply Sleep , Sleep Tabs, Sleepinal, Sominex, Sominex Maximum Strength, Theraflu Multi-Symptom Strip, Triaminic Allergy Thin Strip, Triaminic Cough and Runny Nose Strip, Tusstat, Unisom, Uni-Tann, Valu-Dryl , Vanamine PD, Vicks Qlearquil Nighttime Allergy Relief, Vicks ZzzQuil Nightime Sleep-Aid
Advocate Pain Relief Stick, Americaine, Anbesol, Anbesol Baby , Anbesol Jr , Banadyne-3, Benzodent, Benz-O-Sthetic, Boil-Ease, Cepacol Sensations, Chloraseptic, Comfort Caine , Dry Socket Remedy, Freez Eez, Little Remedies for Teethers, Monistat Care, Orabase, OraCoat CankerMelts, Orajel, Orajel Baby, Orajel Denture Plus, Orajel Maximum Strength, Orajel P.M., Orajel Protective, Orajel Severe Pain, Orajel Swabs, Orajel Ultra, Oral Pain Relief , Oticaine , Otocain, Outgro, Pinnacaine, Pro-Caine, RE Benzotic, Topex, Topicale Xtra, Zilactin-B
ANX , Atarax, Hyzine , Rezine, Vistaril, Vistaril Solution, Vistaril Suspension
All Day Allergy , All Day Allergy Children's, Allergy Relief, Children's Allergy Relief, PediaCare Children's Allergy, Quzyttir, ZERVIATE, Zyrtec, Zyrtec Chewable, Zyrtec Children's, Zyrtec Children's Allergy , ZYRTEC Children's Dye Free, Zyrtec Children's Hives , Zyrtec Dissolve, ZYRTEC Dye Free, Zyrtec Hives Relief , Zyrtec Liquid Gel , Zyrtec Pre-Filled Spoons, Zyrtec Syrup
Alavert, Allergy Relief, Claritin, Claritin 24 Hour, Claritin Chewable, Claritin Hives Relief, Claritin Liqui-Gel, Claritin RediTab, Clear-Atadine , Dimetapp Children's Non-Drowsy Allergy, QlearQuil All Day & All Night Allergy Relief, Quality Choice Allergy Relief Non-Drowsy, Tavist ND
Allegra, Allegra Allergy 12 Hour , Allegra Allergy 24 Hour, Allegra Children's Allergy , Allegra Children's Allergy ODT, Allegra Hives, Allegra ODT, Allergy Relief, Children's Allergy
Prudoxin, Silenor, Sinequan, Zonalon
Locholest , Locholest Light, Prevalite , Questran, Questran Light
Active-PAC with Gabapentin, Gabarone , Gralise, Horizant, Neurontin
quiz link

Test your knowledge

Take a Quiz!