Treating any disorders contributing to memory loss may help restore memory. For example, vitamin B12 deficiency is treated with vitamin B12 supplements, and an underactive thyroid gland is treated with thyroid hormone supplements. For depression, treatment involves drugs, psychotherapy, or both. Doctors choose antidepressants that do not worsen memory loss, such as selective serotonin reuptake inhibitors Selective serotonin reuptake inhibitors (SSRIs) Agomelatine, a new type of antidepressant, is a possible treatment for major depressive episodes. Several types of drugs can be used to treat depression: Selective serotonin reuptake inhibitors... read more (SSRIs). For normal-pressure hydrocephalus, a shunt can be surgically placed to drain the excess fluid around the brain. If a person is taking drugs that affect brain function, doctors may stop the drug, decrease the dose, or try substituting another drug.