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Overview of Blood Clotting Disorders

By Joel L. Moake, MD, Professor Emeritus of Medicine, Baylor College of Medicine; Senior Research Scientist and Associate Director, J. W. Cox Laboratory for Biomedical Engineering, Rice University

(See also How Blood Clots.)

Abnormal bleeding means that people bruise and bleed too easily (see Bruising and Bleeding). Abnormal bleeding can result from disorders of

Clotting disorders occur when the body is unable to make sufficient amounts of the proteins that are needed to help the blood clot, stopping bleeding. These proteins are called clotting factors (coagulation factors). All clotting factors are made in the liver. The liver requires vitamin K to make some of the clotting factors.

Disorders of coagulation can be

  • Hereditary

  • The result of some other disorder

The most common hereditary coagulation disorders are

The primary causes of coagulation disorders that develop as a result of another disorder are