Problems in the joints, nervous system, blood, skin, kidneys, gastrointestinal tract, lungs, and other tissues and organs can develop.
Blood tests and sometimes other tests are done to make the diagnosis.
All people with lupus need hydroxychloroquine and people with lupus that is continuing to cause damage (active lupus) also need corticosteroids and other drugs that suppress the immune system.
About 70 to 90% of people who have lupus are women of child-bearing age, but children (mostly girls), older men and women, and even newborns can also be affected. Lupus occurs in all parts of the world but may be more common among Black people and Asian people than White people.
The cause of lupus is usually not known. Occasionally, the use of certain drugs (such as hydralazine and procainamide, which are used to treat heart conditions, and isoniazid, which is used to treat tuberculosis) can cause lupus. Drug-induced lupus usually disappears after the drug is stopped.
The number and variety of antibodies that can appear in lupus are greater than those in any other disorder. These antibodies may sometimes determine which symptoms develop. However, the levels of these antibodies may not always be proportional to the person’s symptoms.
Discoid lupus erythematosus (DLE), sometimes called chronic cutaneous lupus erythematosus, is a form of lupus that affects only the skin. In this condition, raised, round, red rashes occur, sometimes progressing to some loss of the skin with scarring and hair loss in affected areas. The rash clusters on light-exposed areas of the skin, such as the face, scalp, and ears. Sometimes a rash or sores also affect the mucous membranes, especially in the mouth. In 10% of people, manifestations of systemic lupus—for example, those affecting the joints, kidneys, and brain—may occur.
Subacute cutaneous lupus erythematosus (SCLE) is a form of lupus that affects mostly the skin, causing various rashes that are widespread, come and go, and may worsen with exposure to sunlight. Red and ring-shaped or psoriasis–like patches may form on the arms, face, and trunk. SCLE differs from DLE because SCLE rarely causes scarring. People commonly have fatigue and joint pains but usually do not have the serious damage to internal organs that can occur in SLE.
Symptoms of Lupus
Symptoms of lupus vary greatly from person to person. Symptoms may begin suddenly with fever, resembling a sudden infection. Or symptoms may develop gradually over months or years with episodes (called flare-ups) of fever, feeling unwell, or any of the symptoms discussed below alternating with periods when symptoms are absent or minimal. Most people with lupus have mild symptoms affecting mostly the skin and joints.
Migraine-type headaches Symptoms A migraine headache is typically a pulsating or throbbing pain that ranges from moderate to severe. It can affect one or both sides of the head. It is often worsened by physical activity, light... read more , epilepsy Types of seizures In seizure disorders, the brain's electrical activity is periodically disturbed, resulting in some degree of temporary brain dysfunction. Many people have unusual sensations just before a seizure... read more , or severe mental disorders (psychoses) may be the first abnormalities that are noticed. Eventually, however, symptoms may affect any organ system.
Joint symptoms, ranging from intermittent joint pains (arthralgias) to sudden inflammation of multiple joints (acute polyarthritis), occur in about 90% of people and may exist for years before other symptoms appear. In long-standing disease, marked joint looseness and deformity may occur (Jaccoud arthropathy or arthritis) but is rare. However, joint inflammation is generally intermittent and usually does not damage the joints.
Skin and mucous membrane problems
Rashes include a butterfly-shaped redness across the nose and cheeks (called a malar rash or butterfly rash), raised bumps or patches of thin skin, and flat or raised red areas on exposed areas of the face and neck, upper chest, and elbows. Blisters and skin ulcers (sores) are rare, but ulcers do commonly occur on mucous membranes, particularly on the roof of the mouth, on the inside of the cheeks, on the gums, and inside the nose.
Generalized or patchy loss of hair (alopecia Alopecia (Hair Loss) Hair loss, also called alopecia, can occur on any part of the body. Hair loss that occurs on the scalp is generally called baldness. Hair loss is often of great concern to people for cosmetic... read more ) is common during flare-ups.
Mottled red areas on the sides of the palms and up the fingers, redness and swelling around the nails, and flat, reddish purple blotches between the knuckles on the inner surfaces of the fingers also may occur. Purplish spots (purpura) may occur because of bleeding in the skin as a result of low platelet levels in the blood.
Long-lasting rashes resulting from exposure to sunlight (photosensitivity) occur in some people with lupus, particularly fair-skinned people.
People with lupus who have Raynaud syndrome Raynaud Syndrome Raynaud syndrome, a functional peripheral arterial disease, is a condition in which small arteries (arterioles), usually in the fingers or toes, narrow (constrict) more tightly than normal in... read more have very pale or bluish fingers and toes when they are exposed to cold.
It is common for people with lupus to feel pain when breathing deeply. The pain is due to recurring inflammation of the sac around the lungs (pleurisy), with or without fluid (effusion—see symptoms of pleural effusion Symptoms Pleural effusion is the abnormal accumulation of fluid in the pleural space (the area between the two layers of the thin membrane that covers the lungs). Fluid can accumulate in the pleural... read more ) inside this sac. Inflammation of the lungs (lupus pneumonitis), resulting in breathlessness, is rare, although minor abnormalities in lung function are common. Life-threatening bleeding into the lungs may rarely occur. Blockage of arteries in the lung caused by blood clots (thrombosis) can also occur.
People with lupus may have chest pain due to inflammation of the sac around the heart (pericarditis Acute Pericarditis Acute pericarditis is inflammation of the pericardium (the flexible two-layered sac that envelops the heart) that begins suddenly, is often painful, and causes fluid and blood components such... read more ). More serious but rare effects on the heart are inflammation of the walls of the coronary arteries (coronary artery vasculitis), which can lead to angina Angina , and inflammation of the heart muscle (myocarditis Myocarditis Myocarditis is inflammation of the muscle tissue of the heart (myocardium) that causes tissue death. Myocarditis may be caused by many disorders, including infection, toxins and drugs that affect... read more ), which can lead to heart failure Heart Failure (HF) Heart failure is a disorder in which the heart is unable to keep up with the demands of the body, leading to reduced blood flow, back-up (congestion) of blood in the veins and lungs, and/or... read more . The valves of the heart can rarely be involved and may need to be surgically repaired. People are at increased risk of coronary artery disease Overview of Coronary Artery Disease (CAD) Coronary artery disease is a condition in which the blood supply to the heart muscle is partially or completely blocked. The heart muscle needs a constant supply of oxygen-rich blood. The coronary... read more .
An infant whose mother has lupus and has a certain type of antibody (anti-Rho/SSA antibody) can be born with heart block Overview of Heart Block Heart block is a delay in the conduction of electrical current as it passes through the conduction system of the heart, including the atrioventricular node, bundle of His, or both bundle branches... read more .
Lymph node and spleen problems
Widespread enlargement of the lymph nodes is common, particularly among children, young adults, and Black people of all ages.
Enlargement of the spleen (splenomegaly Enlarged Spleen An enlarged spleen is not a disease in itself but the result of an underlying disorder. Many disorders can make the spleen enlarge. Many disorders, including infections, anemias, and cancers... read more ) occurs in about 10% of people.
Nervous system problems
Involvement of the brain (neuropsychiatric lupus) can cause headaches Overview of Headache A headache is pain in any part of the head, including the scalp, upper neck, face, and interior of the head. Headaches are one of the most common reasons people visit a doctor. Headaches interfere... read more , mild impairment of thinking, personality changes, stroke Overview of Stroke A stroke occurs when an artery to the brain becomes blocked or ruptures, resulting in death of an area of brain tissue due to loss of its blood supply (cerebral infarction) and symptoms that... read more , seizures Seizure Disorders In seizure disorders, the brain's electrical activity is periodically disturbed, resulting in some degree of temporary brain dysfunction. Many people have unusual sensations just before a seizure... read more , severe mental disorders (psychoses), or a condition in which a number of physical changes may occur in the brain, resulting in disorders such as dementia Dementia Dementia is a slow, progressive decline in mental function including memory, thinking, judgment, and the ability to learn. Typically, symptoms include memory loss, problems using language and... read more . The nerves in the body or spinal cord may also be damaged.
Kidney involvement may be minor and without symptoms or may be progressive and fatal. People may develop kidney failure Overview of Kidney Failure This chapter includes a new section on COVID-19 and acute kidney injury (AKI). Kidney failure is the inability of the kidneys to adequately filter metabolic waste products from the blood. Kidney... read more that requires dialysis Dialysis Dialysis is an artificial process for removing waste products and excess fluids from the body, a process that is needed when the kidneys are not functioning properly. There are a number of reasons... read more . The kidneys can be affected at any time and may be the only organ affected by lupus. The most common results of kidney impairment are high blood pressure and protein in the urine that leads to swelling (edema) in the legs.
The numbers of red blood cells, white blood cells, and platelets may decrease. Platelets assist in blood clotting, so if these numbers decrease greatly, bleeding may occur. Also, and for other reasons, the blood may clot too easily, which accounts for many of the problems that can affect other organs (such as strokes Overview of Stroke A stroke occurs when an artery to the brain becomes blocked or ruptures, resulting in death of an area of brain tissue due to loss of its blood supply (cerebral infarction) and symptoms that... read more and blood clots to the lungs Pulmonary Embolism (PE) Pulmonary embolism is the blocking of an artery of the lung (pulmonary artery) by a collection of solid material brought through the bloodstream (embolus)—usually a blood clot (thrombus) or... read more or repeated miscarriages Miscarriage A miscarriage is the loss of a fetus before 20 weeks of pregnancy. Miscarriages may occur because of a problem in the fetus (such as a genetic disorder or birth defect) or in the woman (such... read more ).
Gastrointestinal tract problems
People may have nausea, diarrhea, and vague abdominal discomfort. The occurrence of these symptoms may be the forewarning of a flare-up. Impairment of blood supply to various parts of the gastrointestinal tract may result in more severe abdominal pain, damage to the liver or pancreas (pancreatitis Overview of Pancreatitis Pancreatitis is inflammation of the pancreas. The pancreas is a leaf-shaped organ about 5 inches (about 13 centimeters) long. It is surrounded by the lower edge of the stomach and the first... read more ), or a blockage or hole (perforation Perforation of the Digestive Tract Any of the hollow digestive organs may become perforated (punctured), which causes a release of gastrointestinal contents and can lead to sepsis (a life-threatening infection of the bloodstream)... read more ) of the gastrointestinal tract.
Pregnant women have a higher-than-normal risk of miscarriage Miscarriage A miscarriage is the loss of a fetus before 20 weeks of pregnancy. Miscarriages may occur because of a problem in the fetus (such as a genetic disorder or birth defect) or in the woman (such... read more and stillbirth Stillbirth Stillbirth is death of a fetus after 20 weeks of pregnancy. Stillbirth may result from a problem in the woman, placenta, or fetus. Doctors do blood tests to try to identify the cause of a stillbirth... read more . Flare-ups are common during pregnancy and especially immediately after delivery (see also Systemic Lupus Erythematosus in pregnancy Systemic Lupus Erythematosus (Lupus) Autoimmune disorders, including Graves disease, are more common among women, particularly pregnant women. The abnormal antibodies produced in autoimmune disorders can cross the placenta and... read more ).
Doctors advise women not to conceive if their lupus has not been controlled during the prior 6 months.
Diagnosis of Lupus
A doctor's examination
Doctors suspect lupus mainly on the basis of the person’s symptoms during a thorough physical examination, particularly in a young woman.
To help confirm the diagnosis, doctors do several laboratory tests. Although there is no single laboratory test that confirms the diagnosis of lupus, doctors do these tests to rule out other connective tissue disorders. Doctors then base the diagnosis of lupus on all of the information they gather, including symptoms, physical examination results, and all test results. Doctors use this information to help them determine whether people meet specific, established criteria that are used to confirm lupus. Nonetheless, because of the wide range of symptoms, distinguishing lupus from similar diseases and making the diagnosis can be difficult.
Although blood test results can help doctors diagnose lupus, they alone cannot confirm a definite diagnosis of lupus because sometimes the abnormalities they detect are present in healthy people or in people who have other disorders.
A blood test can detect antinuclear antibodies (ANA), which are present in almost all people who have lupus. However, these antibodies also occur in other diseases. Therefore, if antinuclear antibodies are detected, a test for antibodies to double-stranded DNA as well as a test for other autoimmune antibodies (autoantibodies) are done. A high level of these antibodies to DNA strongly supports the diagnosis of lupus, but not all people who have lupus have these antibodies.
Other blood tests, such as measuring the level of complement proteins (proteins with various immune functions, such as killing bacteria), are also done and can help predict the activity and course of the disease in some people.
Women with lupus who have repeated miscarriages or have had problems with blood clots should be tested for antiphospholipid antibodies. This is an important test when planning contraceptive methods or pregnancy. This blood test, which detects antibodies to phospholipids, can also help identify people at risk of repeated blood clots. Women with positive antibodies to phospholipids should not take estrogen-containing oral contraceptives and should choose other methods of contraception.
Blood tests can also indicate a low red blood cell count (anemia Overview of Anemia Anemia is a condition in which the number of red blood cells is low. Red blood cells contain hemoglobin, a protein that enables them to carry oxygen from the lungs and deliver it to all parts... read more ), a low white blood cell count, or a low platelet count. People who have anemia undergo a direct Coombs test. This test is used to detect increased amounts of certain antibodies that are attached to the surface of red blood cells and can destroy red blood cells, causing anemia.
Additional laboratory tests are done to detect the presence of protein or red blood cells in the urine (urinalysis Urinalysis and Urine Culture Urinalysis, the testing of urine, may be necessary in the evaluation of kidney and urinary tract disorders and can also help evaluate bodywide disorders such as diabetes or liver problems. A... read more ) or an elevation of creatinine in the blood. These findings indicate kidney inflammation of the filtering structure in the kidneys (glomeruli), a condition referred to as glomerulonephritis Glomerulonephritis Glomerulonephritis is a disorder of glomeruli (clusters of microscopic blood vessels in the kidneys with small pores through which blood is filtered). It is characterized by body tissue swelling... read more . Sometimes a kidney biopsy (removal of tissue for examination and testing) is done to help the doctor plan treatment. People who have lupus should be tested frequently for kidney damage even if they have no symptoms (see Kidney Function Tests Kidney Function Tests Doctors can assess kidney function by doing tests on blood and urine samples. Creatinine, a waste product, is increased in the blood when kidney function is decreased by a large amount. Creatinine... read more ).
Prognosis for Lupus
Lupus tends to be chronic and relapsing, often with symptom-free periods (remissions) that can last for years. Flare-ups can be triggered by sun exposure, infection, surgery, or pregnancy. Flare-ups in women occur less often after menopause.
Many people are being diagnosed earlier and with milder lupus than in the past, and better treatment is available. As a result, in most developed countries, more than 95% of people live for at least 10 years after the diagnosis is made. However, because the course of lupus is unpredictable, the prognosis varies widely. Usually, if the initial inflammation is controlled, the long-term prognosis is good. Early detection and treatment of kidney damage reduce the incidence of severe kidney disease. However, people who have lupus have an increased risk of heart disease.
Treatment of Lupus
Hydroxychloroquine (an antimalarial drug) for all affected people
Nonsteroidal anti-inflammatory drugs for mild joint symptoms and corticosteroid creams for mild skin symptoms
Corticosteroids, immunosuppressive drugs, and antimalarial drugs for severe disease
Treatment of lupus depends on which organs are affected and how active the inflammation is. The severity of organ damage in lupus is not necessarily the same as the activity of inflammation. For example, organs may be permanently damaged and scarred from lupus that caused inflammation in the past. Such damage may be referred to as “severe,” even if the lupus is not active (that is, it is not causing any inflammation or any further damage at this time). The goal of treatment is to decrease the activity of lupus—that is, to decrease inflammation, which in turn should prevent new or further damage.
The antimalarial drug hydroxychloroquine is given by mouth to all people who have lupus regardless of whether their disease is mild or severe because it decreases flare-ups and decreases their risk of death. However, hydroxychloroquine is not given to people who have G6PD deficiency Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited genetic disorder that can result in destruction of red blood cells (hemolysis) after an acute illness or use of certain drugs... read more (G6PD is an enzyme that protects red blood cells from certain toxic chemicals) because the drug can rapidly destroy red blood cells. People who take hydroxychloroquine should have periodic eye examinations because this drug slightly increases the risk of damage to the back of the eye when it is taken for many years.
Mild to moderate lupus
If lupus is not very active, causing mild joint or skin symptoms, treatment may not need to be intensive. Nonsteroidal anti-inflammatory drugs Nonsteroidal Anti-Inflammatory Drugs Pain relievers (analgesics) are the main drugs used to treat pain. Doctors choose a pain reliever based on the type and duration of pain and on the drug's likely benefits and risks. Most pain... read more (NSAIDs) often can relieve joint pain but should usually not be taken for long periods of time uninterrupted. Antimalarial drugs, such as hydroxychloroquine, chloroquine, or quinacrine, help relieve skin and joint symptoms and reduce the frequency of flare-ups.
People who have rashes or sores should stay out of direct sunlight and use strong sunscreens Sunscreens Sunburn results from a brief (acute) overexposure to ultraviolet (UV) light. Overexposure to ultraviolet light causes sunburn. Sunburn causes painful reddened skin and sometimes blisters, fever... read more (with a sun protection factor of at least 30) when outside. Rashes may also be treated with corticosteroid creams or ointments.
If skin symptoms are not relieved by corticosteroid creams or ointments and hydroxychloroquine, people are given a combination of hydroxychloroquine and quinacrine or a combination of hydroxychloroquine and methotrexate, mycophenolate mofetil, or azathioprine. People with frequent flares may also be given belimumab, a drug that reduces the activity of certain white blood cells involved in the autoimmune response in people with lupus.
People who have severe, active lupus affecting the kidneys or brain, or causing lung bleeding are treated immediately, usually with the corticosteroid methylprednisolone given by vein (see ). Then people are given the corticosteroid prednisone taken by mouth. The dose and duration of treatment depend on which organs are affected. The immunosuppressive drug cyclophosphamide is also given to suppress the body’s autoimmune attack. Mycophenolate mofetil is a commonly used alternative for severe lupus affecting the kidneys because it is as effective as and less toxic than cyclophosphamide. Other immunosuppressive drugs such as belimumab, voclosporin, or anifrolumab also help reduce lupus symptoms in some people.
People who have end-stage kidney disease can undergo a kidney transplantation as an alternative to dialysis.
People who have certain blood problems are given moderate or high doses of corticosteroids by mouth along with an immunosuppressive drug such as azathioprine or mycophenolate mofetil. They may be given immune globulin (a substance that contains large quantities of many antibodies) by vein. People who are not helped by those treatments may be given the immunosuppressive drug rituximab.
People who have nervous system problems may be given cyclophosphamide or rituximab by vein.
People who develop blood clots are given heparin, warfarin, or other anticoagulants (drugs that are sometimes called blood thinners).
People with severe lupus often notice their symptoms have lessened after 4 to 12 weeks of treatment.
Maintenance drug therapy
Once the initial inflammation is controlled, a doctor determines the lowest dose of corticosteroids and other drugs that control inflammation (such as antimalarial drugs and immunosuppressants) that is needed to most effectively suppress inflammation over the long term. Usually, the dose of prednisone is gradually decreased when symptoms are controlled and laboratory test results show improvement. Relapses or flare-ups can occur during this process. For most people who have lupus, the dose of prednisone can eventually be decreased or discontinued. Because the long-term use of high doses of corticosteroids leads to many side effects, people who need to take high doses of corticosteroids for a long time are given an alternative drug such as azathioprine, methotrexate, or mycophenolate mofetil.
People who take corticosteroids should be tested periodically and, if necessary, treated for osteoporosis Osteoporosis Osteoporosis is a condition in which a decrease in the density of bones weakens the bones, making breaks (fractures) likely. Aging, estrogen deficiency, low vitamin D or calcium intake, and... read more , which can occur with chronic corticosteroid use. People who take high doses of corticosteroids for long periods may be given calcium and vitamin D supplements Calcium and vitamin D Osteoporosis is a condition in which a decrease in the density of bones weakens the bones, making breaks (fractures) likely. Aging, estrogen deficiency, low vitamin D or calcium intake, and... read more and bisphosphonates Drugs Osteoporosis is a condition in which a decrease in the density of bones weakens the bones, making breaks (fractures) likely. Aging, estrogen deficiency, low vitamin D or calcium intake, and... read more to help prevent osteoporosis even if their bone density is normal.
People who are receiving immunosuppressants are also given drugs to prevent infections such as by the fungus Pneumocystis jirovecii (see prevention of pneumonia in immunocompromised people Prevention Pneumonia is infection of the lungs. Pneumonia in people whose immune system is weakened or impaired (for example, by acquired immunodeficiency syndrome [AIDS], cancer, organ transplantation... read more ) and vaccines against common infections such as pneumonia Pneumococcal Vaccine Pneumococcal vaccines help protect against bacterial infections caused by Streptococcus pneumoniae (pneumococci). Pneumococcal infections include ear infections, sinusitis, pneumonia... read more , influenza Influenza Vaccine The influenza virus vaccine helps protect against influenza. Two types of influenza virus, type A and type B, regularly cause seasonal epidemics of influenza in the United States. There are... read more , and COVID-19 COVID-19 Vaccine Coronavirus disease 2019 (COVID-19) vaccines provide protection against COVID-19. COVID-19 is the disease caused by infection with the SARS-CoV-2 virus. There are multiple COVID-19 vaccines... read more .
Other medical conditions and pregnancy
All people should be monitored closely by a doctor for heart disease. Common risk factors for coronary artery disease Overview of Coronary Artery Disease (CAD) Coronary artery disease is a condition in which the blood supply to the heart muscle is partially or completely blocked. The heart muscle needs a constant supply of oxygen-rich blood. The coronary... read more (for example, high blood pressure, diabetes, and high cholesterol levels) should be controlled as well as possible.
Surgical procedures and pregnancy may be more complicated for people who have lupus, and they require close medical supervision. If pregnant, women should remain on hydroxychloroquine throughout their pregnancy and may be given low-dose aspirin as well. Pregnant women who are at risk of blood clots may be given heparin. Miscarriages and flare-ups during pregnancy are common.
Women should avoid becoming pregnant during a flare-up. Because mycophenolate mofetil causes birth defects, women should wait to become pregnant until their disease has been well controlled for 6 months or longer (see lupus during pregnancy Systemic Lupus Erythematosus (Lupus) Autoimmune disorders, including Graves disease, are more common among women, particularly pregnant women. The abnormal antibodies produced in autoimmune disorders can cross the placenta and... read more ). Women who are in remission and who are thinking about becoming pregnant but who need to keep taking maintenance drugs are usually switched from mycophenolate mofetil to azathioprine at least 6 months before conceiving.
The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.
Lupus Foundation of America: Provides information about living with lupus and ongoing lupus research
Drugs Mentioned In This Article
|Generic Name||Select Brand Names|
|No brand name available|
|Procanbid, Pronestyl, Pronestyl-SR|
|Benlysta, Benlysta SC|
|A-Methapred, Depmedalone-40, Depmedalone-80 , Depo-Medrol, Medrol, Medrol Dosepak, Solu-Medrol|
|Deltasone, Predone, RAYOS, Sterapred, Sterapred DS|
|Cyclophosphamide, Cytoxan, Neosar|
|RIABNI, Rituxan, RUXIENCE, truxima|
|Hepflush-10 , Hep-Lock, Hep-Lock U/P, Monoject Prefill Advanced Heparin Lock Flush, SASH Normal Saline and Heparin|
|Otrexup, Rasuvo, RediTrex, Rheumatrex, Trexall, Xatmep|
|Calcidol, Calciferol, D3 Vitamin, DECARA, Deltalin, Dialyvite Vitamin D, Dialyvite Vitamin D3, Drisdol, D-Vita, Enfamil D-Vi-Sol, Ergo D, Fiber with Vitamin D3 Gummies Gluten-Free, Happy Sunshine Vitamin D3, MAXIMUM D3, PureMark Naturals Vitamin D, Replesta, Replesta Children's, Super Happy SUNSHINE Vitamin D3, Thera-D 2000, Thera-D 4000, Thera-D Rapid Repletion, THERA-D SPORT, UpSpring Baby Vitamin D, UpSpring Baby Vitamin D3|
|Anacin Adult Low Strength, Aspergum, Aspir-Low, Aspirtab , Aspir-Trin , Bayer Advanced Aspirin, Bayer Aspirin, Bayer Aspirin Extra Strength, Bayer Aspirin Plus, Bayer Aspirin Regimen, Bayer Children's Aspirin, Bayer Extra Strength, Bayer Extra Strength Plus, Bayer Genuine Aspirin, Bayer Low Dose Aspirin Regimen, Bayer Womens Aspirin , BeneHealth Aspirin, Bufferin, Bufferin Extra Strength, Bufferin Low Dose, DURLAZA, Easprin , Ecotrin, Ecotrin Low Strength, Genacote, Halfprin, MiniPrin, St. Joseph Adult Low Strength, St. Joseph Aspirin, VAZALORE, Zero Order Release Aspirin, ZORprin|