Hiccups are repeated involuntary spasms of the diaphragm, followed by quick, noisy closings of the glottis. The diaphragm is the muscle that separates the chest from the abdomen and that is responsible for each breath. The glottis is the opening between the vocal cords, which closes to stop the flow of air to the lungs. Hiccups are more common among men.
Brief episodes of hiccups (lasting a few minutes) are very common. Occasionally, hiccups persist for some time, even in healthy people. Sometimes hiccups can last more than 2 days or even more than 1 month. These longer episodes are called persistent hiccups. Persistent hiccups are uncommon but can be quite distressing.
Causes of Hiccups
Doctors are not clear why hiccups happen but they think it may involve irritation of the nerves or the parts of the brain that control muscles of respiration (including the diaphragm).
Brief episodes of hiccups often have no obvious cause but sometimes are triggered by
A bloated stomach
Alcohol consumption
Swallowing hot or irritating substances
In such cases, hiccups usually start in a social situation, perhaps triggered by some combination of laughing, talking, eating, and drinking (particularly alcohol). Sometimes hot or irritating food or liquids are the cause. Hiccups are more likely to occur when carbon dioxide levels in the blood decrease. Such a decrease can occur when people hyperventilate.
Persistent episodes of hiccups sometimes have more serious causes ( see Table: Some Causes and Features of Persistent Hiccups Some Causes and Features of Persistent Hiccups 
). For example, the diaphragm may become irritated because of pneumonia, chest or stomach surgery, or waste products that accumulate in the blood when the kidneys malfunction (uremia). Rarely, hiccups develop when a brain tumor Overview of Brain Tumors A brain tumor can be a noncancerous (benign) or cancerous (malignant) growth in the brain. It may originate in the brain or have spread (metastasized) to the brain from another part of the body... read more or stroke Overview of Stroke A stroke occurs when an artery to the brain becomes blocked or ruptures, resulting in death of an area of brain tissue due to loss of its blood supply (cerebral infarction). Symptoms occur suddenly... read more interferes with the breathing center in the brain.
When the cause is serious, hiccups tend to persist until the cause is corrected. Hiccups due to a brain tumor or stroke may be very hard to stop and may become exhausting.
Evaluation of Hiccups
Brief episodes of hiccups do not require evaluation by a doctor. For persistent hiccups, the following information can help people decide whether a doctor’s evaluation is needed and help them know what to expect during the evaluation.
Warning signs
In people with hiccups, certain symptoms and characteristics are cause for concern. They include
Neurologic symptoms (such as headache, weakness, numbness, and loss of balance)
When to see a doctor
People who have hiccups and warning signs should see a doctor right away. People without warning signs should see a doctor if hiccups last more than 2 or 3 days.
What the doctor does
Doctors first ask questions about the person's symptoms and medical history. Doctors then do a physical examination. What doctors find during the history and physical examination often suggests a cause of the hiccups and the tests that may need to be done ( see Table: Some Causes and Features of Persistent Hiccups Some Causes and Features of Persistent Hiccups ).
The history is focused on how long the hiccups have lasted, what remedies the person has tried, and whether the person has recently been ill or had surgery. Doctors also ask people whether they have any
Symptoms of gastroesophageal reflux
Swallowing difficulties
Cough, fever, or chest pain
Neurologic symptoms (such as headaches and/or difficulty walking, talking, speaking, or seeing)
Doctors also ask people about their use of alcohol.
The physical examination is focused on a full neurologic examination. A general examination usually does not reveal much, but doctors look for signs of chronic disease such as severe wasting away of muscle and fat tissue (cachexia).
Testing
Doctors generally do not do any testing for people who have brief hiccups.
People who have warning signs or whose hiccups are persistent and have no obvious cause should have testing. Doctors typically begin with blood tests, chest x-rays, and electrocardiography (ECG) Electrocardiography Electrocardiography (ECG) is a quick, simple, painless procedure in which the heart’s electrical impulses are amplified and recorded. This record, the electrocardiogram (also known as an ECG)... read more 
. Other tests are done based on the other symptoms people have ( see Table: Some Causes and Features of Persistent Hiccups Some Causes and Features of Persistent Hiccups ). If these tests do not reveal a cause, doctors may do magnetic resonance imaging (MRI) Magnetic Resonance Imaging (MRI) Magnetic resonance imaging (MRI) is a type of medical imaging that uses a strong magnetic field and very high frequency radio waves to produce highly detailed images. During an MRI, a computer... read more 
of the brain and computed tomography (CT) Computed Tomography (CT) Computed tomography (CT) is a type of medical imaging that combines a series of x-rays to create cross-sectional, detailed images of internal structures. In computed tomography (CT), which used... read more 
of the chest even if people do not have other symptoms specifically related to these areas.
Treatment of Hiccups
The best way to treat hiccups is to treat the underlying disorder. For example, doctors give people antibiotics for pneumonia and proton pump inhibitors for gastroesophageal reflux disease.
Brief hiccups
Nearly all hiccups go away with or without treatment. Many home remedies have been used to treat brief hiccups. Most do not work or are only slightly effective. However, because these remedies typically are safe and simple to do, there is no harm in trying them. Many methods involve ways to raise the level of carbon dioxide in the blood, such as the following:
Holding the breath
Breathing deeply into a paper (not plastic) bag
Other methods are done to try to stimulate the vagus nerve, which runs from the brain to the stomach. The following can stimulate this nerve:
Drinking water quickly
Swallowing dry bread, granulated sugar, or crushed ice
Gently pulling on the tongue
Stimulating gagging (such as by sticking a finger down the throat)
Gently rubbing the eyeballs
Persistent hiccups
For persistent hiccups, treatment is needed, particularly when the cause cannot be easily corrected. Several drugs have been used with varying success. They include but are not limited to chlorpromazine, baclofen, metoclopramide, and gabapentin.
If drugs do not work, doctors may block one of the phrenic nerves, which control the contractions of the diaphragm. Doctors block the nerve by injecting it with small amounts of a local anesthetic called procaine. If blocking the nerve works but hiccups return, doctors may surgically cut the nerve (phrenicotomy), but even this procedure does not cure all cases.
Key Points
The cause is usually unknown.
Although rare, a serious disorder is sometimes present.
A doctor’s evaluation typically does not reveal a cause but should be done for hiccups that are persistent.
Numerous remedies exist, but none is superior to or more effective than the other ones.
Drugs Mentioned In This Article
| Generic Name | Select Brand Names |
|---|---|
chlorpromazine |
Thorazine |
baclofen |
ED Baclofen, FLEQSUVY, Gablofen, Lioresal, Lioresal Intrathecal, LYVISPAH, OZOBAX, OZOBAX DS |
metoclopramide |
Gimoti, Metozolv, Reglan |
gabapentin |
Active-PAC with Gabapentin, Gabarone , Gralise, Horizant, Neurontin |
