Merck Manual

Please confirm that you are not located inside the Russian Federation

honeypot link
Common Side Effects of Injectable Antihyperglycemic Medications*

Common Side Effects of Injectable Antihyperglycemic Medications*

Medication

Some Potential Side Effects

Glucagon-like peptide medication

All glucagon-like peptide medications can cause

  • Nausea

  • Vomiting

  • Diarrhea or constipation

Albiglutide

Dulaglutide

Exenatide

Kidney damage (rare)

Extended-release exenatide

Injection site nodule

Liraglutide

Lixisenatide

Semaglutide

Dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist

Tirzepatide

Diarrhea

Nausea or decreased appetite

Amylin-like medication

Pramlintide

Nausea

Low blood glucose levels

Semaglutide is also available as a tablet to take orally.