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(Malignant Melanoma)


Gregory L. Wells

, MD, Idaho College of Osteopathic Medicine

Last full review/revision Jan 2021| Content last modified Jan 2021
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Melanoma is a skin cancer that begins in the pigment-producing cells of the skin (melanocytes).

  • Melanomas can begin on normal skin or in existing moles.

  • They may be irregular, flat or raised brown patches of skin with spots of different colors or firm black or gray lumps.

  • To diagnose melanoma, doctors do a biopsy.

  • Melanomas are removed.

  • If they have spread, chemotherapy drugs and radiation therapy are used, but cure is difficult.

Melanocytes are the pigment-producing cells in the skin that give skin its distinctive color. Sunlight stimulates melanocytes to produce more melanin (the pigment that darkens the skin) and increases the risk of melanoma.

In 2020, about 100,350 new cases of melanoma are estimated to occur in the United States, causing an estimated 6,850 deaths. Although melanoma accounts for less than 5% of all skin cancers diagnosed in the United States, it causes the most skin cancer deaths. Every hour, one person in the United States dies of melanoma.

Melanoma usually begins on normal skin as a new, small, pigmented growth, most often on sun-exposed areas. About one in three melanomas develops in a preexisting mole. Melanoma may also occur around and inside the eyes, in the mouth, on the genitals and rectal areas, in the brain, and in the nail beds.

Melanoma readily spreads (metastasizes) to distant parts of the body, where it continues to grow and destroy tissue.

The two most common types of melanoma are

  • Superficial spreading melanoma: This type accounts for 70% of melanomas and occurs most commonly on women’s legs and men’s torsos. The tumor cells commonly have mutations in the BRAF gene.

  • Nodular melanoma: This type accounts for 15 to 30% of melanomas, occurs anywhere on the body, and grows rapidly.

Risk Factors of Melanoma

Risk factors for melanoma include the following:

  • Sun exposure (mainly repeated blistering sunburns)

  • Repeated tanning with ultraviolet A (UVA) or medical treatment with psoralen plus ultraviolet A (PUVA)

  • Personal history of skin cancer (another melanoma or another type of skin cancer)

  • Family members with melanoma

  • Fair skin, freckling

  • Large numbers of pigmented moles or presence of atypical moles (especially more than 5)

  • A weakened immune system

  • A large congenital melanocytic nevus (giant congenital nevus)

People who have had melanoma are at increased risk of developing a new melanoma.

Melanoma is less common among people who have darker skin. When melanoma does develop in darker-skinned people, it often develops in the nail beds and on the palms and soles.

Melanomas are very rare in childhood. However, congenital melanocytic nevus is a dark-colored patch of skin, like a mole or a birthmark, that is present at birth. When large in size, for example, more than about 8 inches (about 20 centimeters), congenital melanocytic nevus is a risk factor for malignant melanoma.

Although melanomas occur during pregnancy, pregnancy does not increase the likelihood that a mole will become a melanoma. Moles frequently change in size and darken during pregnancy.

All people should know the ABCDEs of melanoma so they can check their moles for any malignant (cancerous) changes.

Symptoms of Melanoma

Melanomas can vary in appearance. Some are flat, irregular brown patches containing small black spots. Others are raised brown patches with red, white, black, or blue spots. Sometimes melanoma appears as a firm red, black, or gray lump.

Less than 10% of melanomas produce no pigment. These so-called amelanotic melanomas may be pink, red, or slightly light-brown and may look like noncancerous growths or a form of nonmelanoma skin cancer.

Diagnosis of Melanoma

  • Biopsy

A new mole or changes in a mole—such as enlargement (especially with an irregular border), darkening, inflammation, spotty color changes, bleeding, itching, tenderness, and pain—are warning signs of possible melanoma and so are the ABCDEs of melanoma. If these or other findings lead doctors to suspect melanoma, they do a biopsy.


The ABCDEs of Melanoma

These warning signs are known as the ABCDEs of melanoma.

  • A—Asymmetry: Asymmetric (irregular) appearance (the two halves of the mole are not equal)

  • B—Borders: Irregular borders (that is, borders seem to blend in with the surrounding skin or are not round or oval)

  • C—Color: Changes in color of an existing mole, especially the spread of brown, black, red, white, or blue pigmentation or a color significantly different or darker than the person's other moles

  • D—Diameter: More than ¼ inch (about 6 millimeters) wide, about the size of most pencil erasers

  • E—Evolution: A new mole in a person over age 30 or a changing mole

For the biopsy, doctors remove the entire growth if it is small or only part of it if it is large. They then examine the sample under a microscope to determine whether the growth is a melanoma and, if so, whether all the cancer has been removed. If the biopsy shows that the growth is a melanoma and the growth has not been completely removed, it is then completely removed.

Most darkly pigmented growths that are removed for biopsy are not melanoma but, rather, simple moles. Nonetheless, removing even many harmless moles is preferable to allowing a single cancer to grow. Some growths are neither simple moles nor melanomas, but something in between. These growths, called atypical moles (dysplastic nevi), sometimes turn into melanoma later.

There are additional tools that doctors may use to help distinguish an atypical mole from a melanoma. These tools include polarized light and dermoscopy, which help to better evaluate the growths.

Prognosis of Melanoma

Melanoma may spread rapidly and cause death within months of diagnosis. The less a melanoma has grown deeper into the skin, the greater the chance that surgery will cure it. Almost 100% of the earliest, most shallow melanomas are cured by surgery. However, melanomas that have grown deeper than about 1/32 inch (about 1 millimeter) into the skin have a higher risk of metastasizing to the lymph nodes and blood vessels.

Once melanoma has metastasized to the lymph nodes, the 5-year survival rate ranges from 25 to 70% depending on how much of the skin over the melanoma has broken down (ulcerated) and the number of affected nodes.

Once melanoma has metastasized to distant parts of the body, the 5-year survival rate is about 10%. Some people live for less than 9 months. However, the course of the disease varies greatly and depends in part on the strength of the body’s immune defenses. Some people survive in apparent good health for several years despite the spread of the melanoma.

Prevention of Melanoma

Because melanoma may be caused by long-term sun exposure, people can help prevent this cancer by doing the following, starting in early childhood:

  • Avoiding the sun: For example, seeking shade, minimizing outdoor activities between 10 AM and 4 PM (when the sun’s rays are strongest), and avoiding sunbathing and the use of tanning beds (particularly adolescents and young adults)

  • Wearing protective clothing: For example, long-sleeved shirts, pants, and broad-brimmed hats

  • Using sunscreen: At least sun protection factor (SPF) 30 with UVA and UVB protection used as directed and reapplied every 2 hours and after swimming or sweating but not used to prolong sun exposure

Doctors do not know with certainty whether these measures reduce the chances of people developing or dying of melanoma. However, sun protection does decrease the risk of developing basal cell carcinoma and squamous cell carcinoma, and using tanning beds, particularly by young people, does seem to increase the risk of melanoma.

Anyone who has had a melanoma is at risk of developing other melanomas. Therefore, such people need regular skin examinations. People who have many moles should have total body skin examinations at least once a year. People can be taught to examine themselves to detect changes in existing moles and to recognize features suggesting melanoma. In people without risk factors, doctors do not know whether routine yearly skin examinations reduce the number of deaths from melanoma.

Treatment of Melanoma

  • Removal of the tumors

  • Possibly imiquimod, cryotherapy, or radiation therapy

  • For tumors that have spread, immunotherapy, targeted therapy, or radiation therapy

Doctors treat melanomas by cutting them out (sometimes using Mohs microscopically controlled surgery), taking a border of almost ½ inch (1 centimeter) or more of skin around the tumor.

For people who have the most shallow melanomas (that is, melanomas that have not invaded past the epidermis—called melanoma in situ) and who cannot have surgery (for example, because their health is too poor) or choose not to (for example, because their melanomas are in cosmetically important areas), doctors may treat with imiquimod cream or may use extreme cold (cryosurgery) to destroy the melanomas.

Did You Know...

  • If diagnosed early, surgery can cure almost 100% of shallow melanomas.

Melanoma that has spread

If melanoma has spread to distant areas (metastasized), surgery is generally not an option, but sometimes localized areas of cancer (for example, the affected lymph nodes) may be surgically removed.

The new immunotherapy drugs pembrolizumab and nivolumab are used to help the body's immune system destroy the cancer. These drugs are called PD-1 inhibitors because they block the action of a protein on the surface of the cancer cell called programmed cell death protein 1. This protein protects the cancer cell from the effects of the immune system. When PD-1 inhibitors block the protein, the immune system is able to attack the cancer cell and kill it. PD-1 inhibitors are proving to be very effective treatments for metastatic melanoma. Ipilimumab is another immunotherapy drug that helps activate certain white blood cells to attack cancer cells and improves survival.

Targeted therapy consists of drugs that attack a cancer cell's innate biologic mechanisms. In targeted therapy, drugs identify abnormal genes that occur only in the cancerous cells. Newer drugs used in targeted therapy that can improve survival in melanoma that has spread include dabrafenib, encorafenib, and vemurafenib. These drugs can often target the actual cancer cells more accurately than older cancer chemotherapy drugs.

Chemotherapy drugs such as dacarbazine and temozolomide can be given by vein to treat melanomas that have spread, but they do not prolong survival and are normally given to people who do not have other options.

Radiation therapy may be used in people whose cancer has spread to the brain.

Other treatments are being investigated, such as other drugs and vaccines that stimulate the body to attack the melanoma cells.

More Information about Melanoma

The following are some English-language resources that may be useful. Please note that THE MANUAL is not responsible for the content of these resources.

See the following sites for comprehensive information about melanoma, including detection, prevention, treatment options, and other resources:

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