Merck Manual

Please confirm that you are not located inside the Russian Federation

honeypot link



Laura Shane-McWhorter

, PharmD, University of Utah College of Pharmacy

Reviewed/Revised Jan 2022 | Modified Sep 2022

What is reishi?

Reishi is a dark mushroom whose botanical name is Ganoderma lucidum. Reishi is considered an adaptogen Adaptogens "Adaptogen" is a term for certain foods and supplements that are said to help the body cope with "stress." Stress may be psychologic (in the mind), but also may be physical (in the body), and... read more , a compound that may help the body cope with stress and boost the immune system.

  • Reishi mushroom is important in traditional medicine systems of several countries in Asia, including China, Japan, and Korea.

  • Other names for this mushroom include red reishi, basidiomycetes mushroom, ling zhi, or ling chih (in China), and mannentake (in Japan).

  • People can eat the whole mushroom, but powdered forms or extracts are mostly commonly used in traditional or alternative medicine.

  • The whole mushroom weighs about 25 to 100 grams.

  • Typical doses of dried mushroom extract range from about 1.5 to 9 grams a day. (However, unlike with prescription drugs, there is often little assurance about the purity and dose of supplements, including their active ingredients.)

What claims are made about reishi?

Proponents of reishi mushroom claim that it can benefit health in many ways, including the following:

Does reishi work?

Any single compound, including reishi, is highly unlikely to have such a broad range of health benefits. Thus, evidence is very unlikely to confirm such multiple benefits.

  • Studies in animals and cells have shown that reishi can protect the kidneys and liver from damage, kill cancer cells, and fight infections.

  • Studies in people have not confirmed these findings.

The evidence from studies in people to show that reishi has the claimed health benefits is limited. Many of these studies are small and of poor quality, and some have contradicted the findings of others.

A well-conducted review found that the evidence was insufficient to show that reishi can be used as the initial treatment for cancer. The evidence does not show whether reishi can prolong survival in people with cancer.

Small studies with weak designs have also shown that reishi mushroom treatment reduces pain and promotes the healing of painful varicella-zoster Chickenpox Chickenpox is a highly contagious viral infection with the varicella-zoster virus that causes a characteristic itchy rash, consisting of small, raised, blistered, or crusted spots. Chickenpox... read more Chickenpox lesions in older adults. Other small studies have found that reishi might reduce fatigue and improve quality of life in people who have had breast cancer. Other evidence indicates that reishi may help relieve urinary tract symptoms in men with an enlarged prostate Benign Prostatic Hyperplasia (BPH) Benign prostatic hyperplasia (BPH) is a noncancerous (benign) enlargement of the prostate gland that can make urination difficult. The prostate gland enlarges as men age. Men may have difficulty... read more .

What are the possible side effects of reishi?

Taking reishi mushroom extract for up to a year might be safe, but taking the powdered form of reishi for more than a month could damage the liver.

  • Other side effects of reishi mushrooms include dry mouth, rashes, upset stomach, diarrhea, headache, nosebleed, and dizziness.

  • The safety of reishi mushroom in pregnant women and women who are breastfeeding has not been thoroughly studied.

  • High doses of reishi could increase bleeding risk in people with certain bleeding disorders, including thrombocytopenia (low level of platelets in blood).

  • Taking high doses of reishi before or during surgery could increase the risk of bleeding.

  • Because reishi might reduce blood pressure, it might worsen low blood pressure in people whose blood pressure is already low.

What drug interactions occur with reishi?

Reishi might lower blood pressure, so taking both reishi and drugs to reduce blood pressure (such as captopril, enalapril, lisinopril, amlodipine, hydrochlorothiazide) might make blood pressure too low.

  • Reishi might slow blood clotting, so combining reishi with drugs that slow clotting (for example, clopidogrel, ibuprofen, naproxen, heparin, and warfarin) might increase the chance of bleeding and bruises.

  • Reishi could make some chemotherapy drugs less effective (although conversely it may make some chemotherapy drugs more effective).

  • Reishi may interfere with a lab test for a serum tumor marker (CA72-4) that indicates the presence of certain types of cancers.

  • In animal studies, reishi may interact with diabetes medications to decrease blood sugar. This has not been shown in humans.


There appears to be no compelling reason to take reishi for most people.

The claimed health benefits of reishi have not been confirmed in high-quality studies in people.

However, reishi is probably safe for most people; even so,

  • Pregnant and breastfeeding women, people with low blood pressure or certain bleeding disorders, and those who are undergoing surgery should avoid reishi.

  • People who take certain drugs (including drugs to slow blood clotting and chemotherapy drugs) should talk to their doctor before taking reishi.

Drugs Mentioned In This Article

Generic Name Select Brand Names
Epaned, Vasotec
Prinivil, QBRELIS, Zestril
Katerzia, Norliqva, Norvasc
Esidrix, Ezide, HydroDIURIL, Microzide, Oretic, Zide
Advil, Advil Children's, Advil Children's Fever, Advil Infants', Advil Junior Strength, Advil Migraine, Caldolor, Children's Ibuprofen, ElixSure IB, Genpril , Ibren , IBU, Midol, Midol Cramps and Body Aches, Motrin, Motrin Children's, Motrin IB, Motrin Infants', Motrin Junior Strength, Motrin Migraine Pain, PediaCare Children's Pain Reliever/Fever Reducer IB, PediaCare Infants' Pain Reliever/Fever Reducer IB, Samson-8
Aflaxen, Aleve, Aleve Arthritis, All Day Pain Relief, All Day Relief, Anaprox, Anaprox DS, EC-Naprosyn, Midol Extended Relief, Naprelan, Naprelan Dose Card, Naprosyn
Hepflush-10 , Hep-Lock, Hep-Lock U/P, Monoject Prefill Advanced Heparin Lock Flush, SASH Normal Saline and Heparin
Coumadin, Jantoven
quiz link

Test your knowledge

Take a Quiz!