(See also Overview of Pigmentation Disorders.)
Vitiligo affects up to 2% of the population.
Etiology of Vitiligo
Etiology of vitiligo is unclear, but melanocytes are lacking in affected areas. Proposed mechanisms include autoimmune destruction of melanocytes, reduced survival of melanocytes, and primary melanocyte defects.
Vitiligo can be familial (autosomal dominant with incomplete penetrance and variable expression) or acquired. Some patients have antibodies to melanin. Up to 30% have other autoimmune antibodies (to thyroglobulin, adrenal cells, and parietal cells) or clinical autoimmune endocrinopathies (Addison disease, diabetes mellitus, pernicious anemia, and thyroid dysfunction). However, the relationship is unclear and may be coincidental. The strongest association is with hyperthyroidism (Graves disease) and hypothyroidism (Hashimoto thyroiditis).
Occasionally, vitiligo occurs after a direct physical injury to the skin (eg, as a response to sunburn). Vitiligo can also result from exposure to vitiligo-inducing phenols (1). Patients may associate the onset of vitiligo with emotional stress.
Immunotherapy for melanoma (eg, BRAF inhibitors, programmed death receptor 1 [PD-1] inhibitors) can trigger vitiligo as an immunologic side effect.
General reference
1. Arowojolu OA, Orlow SJ, Elbuluk N, et alExp Dermatol 26(7):637-644. doi: 10.1111/exd.13350
Symptoms and Signs of Vitiligo
Vitiligo is characterized by hypopigmented or depigmented areas, usually sharply demarcated and often symmetric. Depigmentation may be localized, involving 1 or 2 spots or entire body segments (segmental vitiligo); rarely, it may be generalized, involving most of the skin surface (universal vitiligo). However, vitiligo most commonly involves the face (especially around the orifices), digits, dorsal hands, flexor wrists, elbows, knees, shins, dorsal ankles, armpits, inguinal area, anogenital area, umbilicus, and nipples. Cosmetic disfigurement can be especially severe and emotionally devastating in dark-skinned patients. Hair in vitiliginous areas is usually white.
Image provided by Thomas Habif, MD.
© Springer Science+Business Media
Image courtesy of Karen McKoy, MD.
© Springer Science+Business Media
Image courtesy of Karen McKoy, MD.
© Springer Science+Business Media
© Springer Science+Business Media
© Springer Science+Business Media
© Springer Science+Business Media
© Springer Science+Business Media
Image provided by Thomas Habif, MD.
© Springer Science+Business Media
Image courtesy of Karen McKoy, MD.
© Springer Science+Business Media
Image courtesy of Karen McKoy, MD.
© Springer Science+Business Media
© Springer Science+Business Media
© Springer Science+Business Media
© Springer Science+Business Media
© Springer Science+Business Media
Diagnosis of Vitiligo
Clinical evaluation
Depigmented skin is typically obvious on examination, especially in darker-skinned people. Subtle hypopigmented or depigmented lesions are accentuated under a Wood light (365 nm), which shows the chalk-white appearance of depigmented skin.
Differential diagnosis includes postinflammatory hypopigmentation, piebaldism (a rare autosomal dominant disorder in which depigmented patches surrounded by hyperpigmented areas occur most often on the forehead, neck, anterior trunk, and mid-extremities), morphea (localized scleroderma, in which skin is usually sclerotic), leprosy (in which lesions are usually hypoesthetic), lichen sclerosus, pityriasis alba, chemical leukoderma, and leukoderma due to melanoma.
Although there are no evidence-based guidelines, it is reasonable for physicians to test for complete blood count, fasting blood glucose, thyroid function, and antithyroid peroxidase antibodies (frequently present in Hashimoto thyroiditis) as clinically indicated by review of systems.
Treatment of Vitiligo
Protection of affected areas from sunlight
Topical calcineurin inhibitors for face or groin involvement
Narrowband ultraviolet B (UVB) or psoralen plus ultraviolet A (PUVA) therapy
Vitiligo can be challenging to manage; initial repigmentation and maintenance of pigment can be unpredictable. Physicians must be aware of individual and ethnic sensibilities regarding uniform skin coloring; the disease can be psychologically devastating. All depigmented areas are prone to severe sunburn and must be protected with clothing or sunscreen.
Oral and topical PUVA are often successful, but over a hundred treatment sessions may be necessary, which can increase risk of skin cancer. Narrowband UVB is as effective as topical PUVA and has few adverse effects, making narrowband UVB preferable to PUVA. Narrowband UVB is often the preferred initial treatment for widespread vitiligo. Excimer laser (308 nm) may be useful, particularly for localized disease that does not respond to initial topical therapy.
Surgery is reasonable only for patients with stable, limited disease when medical therapy has failed. Therapies include autologous micrografting (1), suction blister grafting, and tattooing; tattooing is especially useful for difficult-to-repigment areas such as the nipples, lips, and fingertips.
skin cancers, photoaging). This treatment can be extremely irritating, so a smaller test area should be treated before widespread use. Treatment for ≥ 1 year may be required.
Treatment references
1. Gan EY, Kong YL, Tan WD, et al: Twelve-month and sixty-month outcomes of noncultured cellular grafting for vitiligo. J Am Acad Dermatol 75(3):564-571, 2016. doi: 10.1016/j.jaad.2016.04.007
2. Rothstein B, Joshipura D, Saraiya A, et alJ Am Acad Dermatol 76(6):1054-1060.e1. doi: 10.1016/j.jaad.2017.02.049
Key Points
Some cases of vitiligo may involve genetic mutations or autoimmune disorders.
Vitiligo can be focal, segmental, or, rarely, generalized.
Diagnose by skin examination and consider testing with complete blood count, fasting blood glucose, thyroid function tests, and antithyroid peroxidase antibodies.
Janus kinase inhibitors are an emerging treatment modality for vitiligo.
More Information
The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.
