A colonic diverticulum is a saclike pouch of colonic mucosa and submucosa that protrudes through the muscular layer of the colon; because it does not contain all layers of the bowel, it is considered a pseudodiverticulum (see also Definition of Diverticular Disease).
Although diverticula can occur anywhere in the large bowel, they usually occur in the sigmoid portion of the colon. They rarely occur below the peritoneal reflection and involve the rectum. Diverticula vary in diameter but typically are 3 to 10 mm in size. Giant diverticula, which are extremely rare, are defined as diverticula > 4 cm in diameter; sizes up to 25 cm have been reported. People who have colonic diverticulosis usually have several diverticula.
Diverticulosis becomes more common with increasing age; it is present in three quarters of people > 80 years.
The etiology of colonic diverticulosis is multifactorial and not entirely known. Several studies have suggested a correlation between symptomatic diverticular disease and environmental factors such as a diet low in fiber or high in red meat, sedentary lifestyle, obesity, smoking, and use of nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and opiates. Other possible risk factors include heritable factors and alterations in the colonic wall structure and motility. Diverticula are possibly caused by an increase in intraluminal pressure, which leads to mucosal extrusion through the weakest points of the muscular layer of the bowel—areas adjacent to intramural blood vessels.
The etiology of giant diverticula is unclear. One theory is that a narrow neck-opening leads to a ball-valve effect with intermittent obstruction of the opening causing the diverticulum to enlarge. A very large giant diverticulum is often a true perforation of a smaller diverticulum that was contained and walled off and became lined mostly by granulation tissue.
Most (80%) patients with diverticulosis are asymptomatic or have only intermittent constipation. About 20% become symptomatic with pain or bleeding when inflammatory or hemorrhagic complications develop.
Patients with diverticulosis sometimes develop nonspecific gastrointestinal (GI) symptoms, including abdominal pain, bloating, constipation, diarrhea, and passage of mucus from the rectum. This constellation is sometimes referred to as symptomatic uncomplicated diverticular disease (SUDD). However, some specialists believe these symptoms are due to another disorder (eg, irritable bowel syndrome), and the presence of diverticula is coincidental rather than causal.
Complications of colonic diverticular disease are more common among people who smoke, are obese, have HIV infection, or use NSAIDs or are undergoing cancer chemotherapy. Complications occur in 15 to 20% of patients and include
Diverticulitis is painful inflammation of a diverticulum. It may be uncomplicated or complicated.
Diverticular bleeding occurs in 10 to 15% of patients with diverticulosis.
Segmental colitis associated with diverticular disease (SCAD) refers to manifestations of colitis (eg, hematochezia, abdominal pain, diarrhea) that develop in a few (1%) patients with diverticulosis. The degree to which the diverticulosis is causal is unclear.
Diverticular bleeding is the most common cause (up to 50%) of brisk lower GI bleeding in adults. A study showed that the cumulative incidence of lower GI bleeding from diverticulosis was about 2% at 5 years and 10% at 10 years (1).
The pathophysiology of diverticular bleeding is unknown, but several mechanisms are hypothesized, including
NSAIDs have been reported to increase the risk of hemorrhage.
Although most diverticula are in the distal (left) colon, half of diverticular bleeding occurs from diverticula in the proximal (right) colon. Patients with pancolonic diverticulosis have a higher incidence of bleeding.
Diverticular bleeding manifests as painless hematochezia. Because the bleeding vessel is an arteriole, the amount of blood loss is usually moderate to severe. Fresh blood or maroon-colored stool is the typical manifestation; rarely, right-sided diverticular bleeding can manifest as melena. Diverticular bleeding usually occurs without concomitant diverticulitis.
The majority (75%) of episodes of bleeding cease spontaneously. The remainder require intervention, typically endoscopic (see also the American College of Gastroenterology's 2016 practice guidelines on management of patients with acute lower gastrointestinal bleeding).
Patients who have had a diverticular bleeding episode have an increased risk of rebleeding. After a second episode of diverticular bleeding, the risk of rebleeding is 50%.
1. Niikura R, Nagata N, Shimbo T, et al: Natural history of bleeding risk in colonic diverticulosis patients: A long-term colonoscopy-based cohort study. Aliment Pharmacol Ther 41(9):888–894, 2015. doi: 10.1111/apt.13148
Asymptomatic diverticula are usually found incidentally during colonoscopy, capsule endoscopy, barium enema, CT, or MRI.
Lower GI bleeding due to diverticulosis is suspected when painless rectal bleeding develops, particularly in an older patient or in a patient who has a history of diverticular disease. Evaluation of lower GI bleeding typically includes colonoscopy, which can be done after rapid colonic preparation: 4 to 6 L of polyethylene glycol solution delivered orally, ideally via a nasogastric tube, and given over 3 to 4 hours until the rectal effluent is clear of blood and stool. If the source cannot be seen with colonoscopy and ongoing bleeding is sufficiently rapid (> 0.5 to 1 mL/minute), CT angiography or radionuclide imaging may localize the source.
Asymptomatic diverticulosis requires no treatment or dietary changes. There is no association between consumption of nuts, seeds, corn, or popcorn and diverticulitis, diverticular hemorrhage, or uncomplicated diverticulosis, and avoidance of these foods is no longer recommended. NSAIDs and opioid analgesics may increase the risk of diverticular perforation and bleeding, therefore these drugs should be used with appropriate caution and after extensive discussion with the patient about the risks.
For diverticulosis with nonspecific GI symptoms, treatment is aimed at reducing spasm of a segment of colon. A high-fiber diet is often recommended and may be supplemented by psyllium seed preparations or bran together with adequate fluid intake. However, the role of fiber in the treatment of diverticulosis is limited. In general, data are inadequate to confirm beneficial effects of fiber. Bulk-forming laxatives should be considered for people with constipation (see also guidelines for diagnosis and management of diverticular disease from the National Institute for Health and Care Excellence). Antispasmodics (eg, belladonna) are not of benefit and may cause adverse effects. Low-fiber diets are not helpful. Surgery is unwarranted for uncomplicated disease except for giant diverticula.
Diverticular bleeding stops spontaneously in 75% of patients. Initial management is as for lower GI bleeding. Treatment of diverticular bleeding is often given during the diagnostic procedure. Colonoscopic identification of a bleeding site (which can occur up to 20% of the time) allows for endoscopic options to control bleeding, including epinephrine injection, application of endoclips or fibrin sealant, heater probe or bipolar coagulation, and band ligation.
Angiography can help with diagnosis of the source of bleeding and treatment of ongoing bleeding. During angiography, a number of techniques can be used to control the bleeding, particularly embolization and, less often, vasopressin injection. Embolization is successful about 80% of the time. Angiographic complications of bowel ischemia or infarction are less common (< 5%) with current super-selective catheterization techniques.
Surgery is rarely needed but is recommended for patients who have had multiple or persistent episodes of diverticular bleeding refractory to therapy or who have hemodynamic instability despite aggressive resuscitation.
If angiography or surgery is being considered, identifying the specific bleeding diverticulum endoscopically or using a nuclear medicine study during active bleeding gives direction to the interventional radiologist and may limit the size of a potential surgical resection. When the bleeding site is known, the need for subtotal colectomy (with its associated higher morbidity and mortality) is markedly reduced because a hemicolectomy or segmental colectomy may be done instead. However, patients who have continued and life-threatening hemorrhage and no identifiable bleeding diverticulum may require a subtotal colectomy.
Colonic diverticula are saclike mucosal pouches that protrude from the colon.
Diverticulosis is increasingly common with age; it is present in about 75% of people > 80 years.
Diverticulosis is usually asymptomatic, but about 20% of patients develop symptoms and/or complications, including inflammation (diverticulitis) and lower gastrointestinal bleeding.
Asymptomatic diverticulosis requires no treatment.
Diverticular bleeding stops spontaneously in about 75% of patients; control the remainder during colonoscopy or angiography, or rarely with surgery.
The following are some English-language resources that may be useful. Please note that THE MANUAL is not responsible for the content of these resources.
American College of Gastroenterology: Practice guidelines on management of adults with acute lower GI bleeding
National Institute for Health and Care Excellence (NICE): Guidelines for diagnosis and management of diverticular disease
Some medical authorities consider symptomatic uncomplicated diverticular disease (SUDD) to be a form of irritable bowel syndrome that occurs coincidentally in patients with diverticulosis.
Patients with SUDD have left lower quadrant abdominal pain with bloating, constipation, diarrhea, or passage of mucus from the rectum. In general, patients have a very low incidence of complications.
Diagnosis of SUDD is difficult because the difference between irritable bowel syndrome and SUDD is not well-defined.
1. Elisei W, Tursi A: Recent advances in the treatment of colonic diverticular disease and prevention of acute diverticulitis. Ann Gastroenterol 29(1):24–32, 2016.
2. Boynton W, Floch M: New strategies for the management of diverticular disease: Insights for the clinician. Therap Adv Gastroenterol 6(3):205–213, 2013. doi: 10.1177/1756283X13478679
Drugs Mentioned In This Article
|Drug Name||Select Trade|