(See also Overview of Pneumonia Overview of Pneumonia Pneumonia is acute inflammation of the lungs caused by infection. Initial diagnosis is usually based on chest x-ray and clinical findings. Causes, symptoms, treatment, preventive measures, and... read more .)
Aspiration can cause lung inflammation (chemical pneumonitis), infection (bacterial pneumonia Overview of Pneumonia Pneumonia is acute inflammation of the lungs caused by infection. Initial diagnosis is usually based on chest x-ray and clinical findings. Causes, symptoms, treatment, preventive measures, and... read more or lung abscess Lung Abscess Lung abscess is a necrotizing lung infection characterized by a pus-filled cavitary lesion. It is most commonly caused by aspiration of oral secretions by patients who have impaired consciousness... read more 
), or airway obstruction Etiology Respiratory arrest and cardiac arrest are distinct, but inevitably if untreated, one leads to the other. (See also Respiratory Failure, Dyspnea, and Hypoxia.) Interruption of pulmonary gas exchange... read more . Microaspiration of small quantities of upper airway secretions is common; however, this aspirated material is cleared by normal lung defense mechanisms. The term aspiration pneumonia is used when the ability to protect the lower airway is compromised and/or a large volume is aspirated. Drowning Drowning Drowning is respiratory impairment resulting from submersion in a liquid medium. It can be nonfatal (previously called near drowning) or fatal. Drowning results in hypoxia, which can damage... read more may also cause inflammation of the lungs.
Risk factors for aspiration include
Impaired cognition or level of consciousness
Impaired swallowing (such as occurs after some strokes Overview of Stroke Strokes are a heterogeneous group of disorders involving sudden, focal interruption of cerebral blood flow that causes neurologic deficit. Strokes can be Ischemic (80%), typically resulting... read more
or other neurologic diseases)Vomiting
Gastrointestinal devices and procedures (eg, nasogastric tube placement)
Dental procedures
Respiratory devices and procedures (eg, endotracheal tube placement—see Ventilator-Associated Pneumonia Ventilator-Associated Pneumonia Ventilator-associated pneumonia (VAP) develops at least 48 hours after endotracheal intubation. The most common pathogens are gram-negative bacilli and Staphylococcus aureus; antibiotic-resistant... read more )
Pathophysiology
Chemical pneumonitis
Multiple substances are directly toxic to the lungs or stimulate an inflammatory response when aspirated; gastric acid is the most common such aspirated substance, but others include petroleum products (particularly of low viscosity, such as petroleum jelly) and laxative oils (such as mineral, castor, and paraffin oil). Petroleum products and laxative oils can cause lipoid pneumonia. Aspirated gasoline and kerosene also cause a chemical pneumonitis (see Hydrocarbon Poisoning Hydrocarbon Poisoning Hydrocarbon poisoning may result from ingestion or inhalation. Ingestion, most common among children < 5 years, can result in aspiration pneumonitis. Inhalation, most common among adolescents... read more ).
Gastric contents cause damage mainly due to gastric acid, although food and other ingested material (eg, activated charcoal as in treatment of overdose) are injurious in quantity. Gastric acid causes a chemical burn of the airways and lungs, leading to rapid bronchoconstriction, atelectasis Atelectasis Atelectasis is collapse of lung tissue with loss of volume. Patients may have dyspnea or respiratory failure if atelectasis is extensive. They may also develop pneumonia. Atelectasis is usually... read more 
, and edema. This syndrome may resolve spontaneously, usually within a few days, or may progress to acute respiratory distress syndrome Acute Hypoxemic Respiratory Failure (AHRF, ARDS) Acute hypoxemic respiratory failure is defined as severe hypoxemia (PaO2 (See also Overview of Mechanical Ventilation.) Airspace filling in acute hypoxemic respiratory failure (AHRF) may result... read more 
. Bacterial superinfection occurs in about 25% of patients.
Aspiration pneumonia
Healthy people commonly aspirate small amounts of oral secretions, but normal defense mechanisms usually clear the inoculum without sequelae. Aspiration of larger amounts, or aspiration in a patient with impaired pulmonary defenses, often causes pneumonia and/or a lung abscess Lung Abscess Lung abscess is a necrotizing lung infection characterized by a pus-filled cavitary lesion. It is most commonly caused by aspiration of oral secretions by patients who have impaired consciousness... read more . Older patients tend to aspirate because of conditions associated with aging that alter consciousness (eg, sedative use) and other disorders (eg, neurologic disorders, swallowing disorders). Empyema (see Pleural Effusion Etiology 
) also occasionally complicates aspiration.
Gram-negative enteric pathogens and oral anaerobes are the most frequent pathogens in aspiration pneumonia.
Symptoms and Signs
Symptoms and signs include
Cough
Fever
Dyspnea
Chest discomfort
Chemical pneumonitis caused by gastric contents causes acute dyspnea with cough that is sometimes productive of pink frothy sputum, tachypnea, tachycardia, fever, diffuse crackles, and wheezing. When oil or petroleum jelly is aspirated, pneumonitis may be asymptomatic and detected incidentally on chest x-ray or may manifest with low-grade fever, gradual weight loss, and crackles.
Diagnosis
Chest x-ray
For aspiration pneumonia, chest x-ray shows an infiltrate, frequently but not exclusively, in the dependent lung segments, ie, the superior or posterior basal segments of a lower lobe or the posterior segment of an upper lobe. For aspiration-related lung abscess, chest x-ray may show a cavitary lesion. Contrast-enhanced computed tomography (CT) is more sensitive and specific for lung abscess and will show a round lesion filled with fluid or with an air-fluid level. Aspiration pneumonitis and pneumonia are distinguished by their clinical course and are indistinguishable by imaging.
In patients with oil or petroleum jelly aspiration, chest x-ray findings vary; consolidation, cavitation, interstitial or nodular infiltrates, pleural effusion, and other changes may be slowly progressive. A CT scan can show fat attenuation within the consolidative opacities and nodules.
Signs of ongoing aspiration may include frequent throat clearing or a wet-sounding cough after eating. Sometimes no signs are present, and ongoing aspiration is only diagnosed via modified barium esophagography done to rule out an underlying swallowing disorder.
Selected patients with unexplained aspiration pneumonitis and aspiration pneumonia should be tested for an underlying swallowing disorder.
Treatment
Antibiotics
Treatment is supportive, often involving supplemental oxygen and mechanical ventilation Overview of Mechanical Ventilation Mechanical ventilation can be Noninvasive, involving various types of face masks Invasive, involving endotracheal intubation Selection and use of appropriate techniques require an understanding... read more . Antibiotics (a beta-lactam/beta-lactamase inhibitor or clindamycin) often are given to patients with witnessed or known gastric aspiration because of the difficulty in excluding bacterial infection as a contributing or primary factor; however, if patients improve rapidly, antibiotics can be stopped. Patients with apparently mild cases can also be observed without initiating antibiotics.
Toxic substances that may cause lipoid pneumonia should be avoided. Anecdotal reports suggest systemic corticosteroids may be beneficial in patients with oil or petroleum jelly aspiration.
For aspiration pneumonia, a beta-lactam/beta-lactamase inhibitor is recommended, with clindamycin being reserved for penicillin allergic patients (1 Treatment reference Aspiration pneumonitis and pneumonia are caused by inhaling toxic and/or irritant substances, most commonly large volumes of upper airway secretions or gastric contents, into the lungs. Chemical... read more ). If aspiration occurs in the hospital setting, a carbapenem or piperacillin/tazobactam can be used; drugs effective against methicillin-resistant Staphylococcus aureus are added if risk factors for that pathogen are present. Duration of treatment is usually 1 to 2 weeks.
Treatment of lung abscess Treatment Lung abscess is a necrotizing lung infection characterized by a pus-filled cavitary lesion. It is most commonly caused by aspiration of oral secretions by patients who have impaired consciousness... read more is with antibiotics and sometimes percutaneous or surgical drainage. Many practitioners continue antibiotic treatment until the chest radiograph shows complete resolution or only a small, stable, residual abnormality.
Treatment reference
1. Metlay JP, Waterer GW, Long AC, et al: Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med 200(7): e45–e67, 2019. https://doi.org/10.1164/rccm.201908-1581ST
Prevention
Strategies to prevent aspiration are important to care and overall clinical outcome. For patients with decreased level of consciousness, avoidance of oral feeding and oral drugs and elevation of the head of the bed to > 30 degrees may help. Sedating drugs should be stopped. Patients with dysphagia (due to stroke or other neurologic conditions) have long been recommended to follow diets with specialized textures to attempt to reduce the risk of aspiration however there is little firm evidence that this is effective. A speech pathologist may be able to train patients in specific strategies (chin tuck, etc.) to reduce the risk of aspiration. For patients with severe dysphagia, a percutaneous gastrostomy or jejunostomy tube is often used, although it is not clear whether this strategy truly reduces the risk of aspiration because patients can still aspirate oral secretions and may have reflux of gastrostomy tube feedings.
Optimization of oral hygiene and regular care by a dentist may help prevent development of pneumonia or abscess in patients who repeatedly aspirate.
Key Points
Some patients with unexplained aspiration pneumonitis and aspiration pneumonia should be evaluated for an underlying swallowing disorder.
Aspiration pneumonia should be treated with antibiotics; treatment of aspiration pneumonitis is primarily supportive.
Secondary prevention of aspiration using various measures is a key component of care for affected patients.
Drugs Mentioned In This Article
| Drug Name | Select Trade |
|---|---|
charcoal |
Actidose With Sorbitol , Actidose-Aqua, Charcoal Plus DS , CharcoCaps Anti-Gas, EZ Char , Kerr INSTA-CHAR |
clindamycin |
Cleocin, Cleocin Ovules, Cleocin Pediatric, Cleocin T, CLIN, Clindacin ETZ, Clindacin-P, Clinda-Derm , Clindagel, ClindaMax, ClindaReach, Clindesse, Clindets, Evoclin, PledgaClin, XACIATO |
piperacillin/tazobactam |
Zosyn, Zosyn Powder |
