Unlike almost all other forms of dementia, HIV-associated dementia tends to occur in younger people.
Usually, the dementia begins subtly but progresses steadily over a few months or years, typically after other symptoms of HIV infection develop.
Doctors diagnose HIV-associated dementia based on symptoms, mental status testing, blood tests for HIV, and imaging tests.
Treating HIV infection with antiretroviral therapy sometimes dramatically improves mental function but does not cure the dementia.
(See also Overview of Delirium and Dementia Overview of Delirium and Dementia Delirium and dementia are the most common causes of mental (cognitive) dysfunction—the inability to acquire, retain, and use knowledge normally. Although delirium and dementia may occur together... read more and Dementia Dementia Dementia is a slow, progressive decline in mental function including memory, thinking, judgment, and the ability to learn. Typically, symptoms include memory loss, problems using language and... read more .)
In the late stages of HIV infection Human Immunodeficiency Virus (HIV) Infection Human immunodeficiency virus (HIV) infection is a viral infection that progressively destroys certain white blood cells and is treated with antiretroviral medications. If untreated, it can cause... read more , the virus may directly infect the brain. HIV damages nerve cells, causing dementia. Dementia Dementia Dementia is a slow, progressive decline in mental function including memory, thinking, judgment, and the ability to learn. Typically, symptoms include memory loss, problems using language and... read more is a slow, progressive decline in mental function including memory, thinking, judgment, and the ability to learn.
In people with HIV infection, dementia may also result from other disorders, including lymphomas Overview of Lymphoma Lymphomas are cancers of lymphocytes, which reside in the lymphatic system and in blood-forming organs. Lymphomas are cancers of a specific type of white blood cells known as lymphocytes. These... read more that affect the brain and infections that people with HIV infection are prone to get because their immune system is weakened. These infections are called opportunistic infections and include progressive multifocal leukoencephalopathy Progressive Multifocal Leukoencephalopathy (PML) Progressive multifocal leukoencephalopathy is a rare infection of the brain that is caused by the JC (John Cunningham) virus. People with a weakened immune system are most likely to get the... read more , toxoplasmosis Toxoplasmosis read more (a parasite infection), and meningitis due to fungi Subacute and Chronic Meningitis Subacute meningitis is inflammation of the layers of tissue that cover the brain and spinal cord (meninges) and of the fluid-filled space between the meninges (subarachnoid space) when it develops... read more (see table Common Opportunistic Infections Associated With AIDS Common Opportunistic Infections Associated with AIDS ). Some of these disorders can be treated, resulting in some improvement.
Unlike almost all other forms of dementia, HIV-associated dementia tends to occur in younger people.
Dementia occurs in 7 to 27% people with late-stage HIV infection, but 30 to 40% may have milder forms of HIV-associated dementia.
Dementia differs from delirium Delirium Delirium is a sudden, fluctuating, and usually reversible disturbance of mental function. It is characterized by an inability to pay attention, disorientation, an inability to think clearly... read more , which is characterized by an inability to pay attention, disorientation, an inability to think clearly, and fluctuations in the level of alertness.
Dementia affects mainly memory, and delirium affects mainly attention.
Dementia typically begins gradually and has no definite beginning point. Delirium begins suddenly and often has a definite beginning point.
Symptoms of HIV-Associated Dementia
HIV-associated dementia usually begins subtly but progresses steadily over a few months or years. It usually develops after other symptoms of HIV infection.
Early symptoms of HIV-associated dementia include
Slowed thinking and expression
But insight is not affected. Movements are slow, muscles are weak, and coordination may be impaired.
In some people, a psychosis, such as hallucinations Hallucinations Healthy people differ significantly in their overall personality, mood, and behavior. Each person also varies from day to day, depending on the circumstances. However, a sudden, major change... read more , delusions Delusions Healthy people differ significantly in their overall personality, mood, and behavior. Each person also varies from day to day, depending on the circumstances. However, a sudden, major change... read more , or paranoia, develops. Some people become manic. That is, they become very restless and overactive. They may speak rapidly and act without good judgment.
Without treatment, HIV-associated dementia usually progresses, eventually becoming severe.
Diagnosis of HIV-Associated Dementia
A doctor's evaluation for dementia, HIV infection, or both
Blood tests to determine how severe HIV infection is
Magnetic imaging and usually a spinal tap
Generally, the diagnosis of dementia in people with HIV infection is similar to that of other dementias.
Doctors must determine whether a person has dementia and, if so, whether the dementia is HIV-associated dementia.
Diagnosis of dementia
Doctors base a diagnosis of dementia on the following:
Symptoms, which are identified by asking the person and family members or other caregivers questions
Results of a physical examination, including a neurologic examination Neurologic Examination When a neurologic disorder is suspected, doctors usually evaluate all of the body systems during the physical examination, but they focus on the nervous system. Examination of the nervous system—the... read more
Results of additional tests, such as computed tomography (CT) or magnetic resonance imaging (MRI)
Mental status testing, consisting of simple questions and tasks, helps doctors determine whether people have dementia.
Neuropsychologic testing, which is more detailed, is sometimes needed. This testing covers all the main areas of mental function, including mood, and usually takes 1 to 3 hours. This testing helps doctors distinguish dementia from other conditions that can cause similar symptoms, such as age-associated memory impairment Dementia , mild cognitive impairment Dementia , and depression Dementia .
Information from the above sources can usually help doctors rule out delirium Dementia Dementia is a slow, progressive decline in mental function including memory, thinking, judgment, and the ability to learn. Typically, symptoms include memory loss, problems using language and... read more as the cause of symptoms (see table Comparing Delirium and Dementia Comparing Delirium and Dementia ). Doing so is essential because delirium, unlike dementia, can often be reversed if promptly treated.
Diagnosis of HIV-associated dementia
If people who are not known to have HIV infection develop symptoms of dementia and have risk factors for HIV infection, doctors may suspect HIV-associated dementia and do tests to check for HIV as well as for dementia.
When HIV infection is diagnosed or when mental function changes in people with HIV infection, magnetic resonance imaging (MRI) is done to check for other causes of brain dysfunction, such as toxoplasmosis Toxoplasmosis read more or lymphoma Overview of Lymphoma Lymphomas are cancers of lymphocytes, which reside in the lymphatic system and in blood-forming organs. Lymphomas are cancers of a specific type of white blood cells known as lymphocytes. These... read more . When mental function changes suddenly, the cause must be identified quickly because early treatment can prolong life. Untreated, HIV-associated dementia may cause death within 6 months.
Unless results of CT or MRI suggest that pressure within the skull is increased, doctors usually do a spinal tap Spinal Tap Diagnostic procedures may be needed to confirm a diagnosis suggested by the medical history and neurologic examination. Electroencephalography (EEG) is a simple, painless procedure in which... read more (lumbar puncture) to obtain a sample of cerebrospinal fluid, which is analyzed. Findings can support but not confirm the diagnosis of HIV-associated dementia.
If people have HIV infection or if HIV-associated dementia is suspected, doctors also do blood tests to measure the following:
The number of white blood cells called CD4 lymphocytes (the CD4 count CD4 count Human immunodeficiency virus (HIV) infection is a viral infection that progressively destroys certain white blood cells and is treated with antiretroviral medications. If untreated, it can cause... read more )
These tests help determine how severe the HIV infection is. Having with a very low CD4 count and a very high viral load increases the risk of developing brain infections, lymphoma, and HIV-associated dementia.
Treatment of HIV-Associated Dementia
Without treatment, HIV-associated dementia can be fatal. However, when HIV infection is treated with antiretroviral therapy Antiretroviral Treatment of Human Immunodeficiency Virus (HIV) Infection Antiretroviral medications used to treat human immunodeficiency virus (HIV) infection aim to do the following: Reduce the amount of HIV RNA (viral load) in the blood to an undetectable amount... read more (ART), mental function sometimes dramatically improves. ART consists of combinations of the medications used to treat HIV infection. However, because the infection is not cured, dementia may recur.
Treatment also includes general measures to provide support, as for other dementias.
Safety and supportive measures
Creating a safe and supportive environment Creating a Beneficial Environment for People With Dementia can be very helpful.
Generally, the environment should be bright, cheerful, safe, stable, and designed to help with orientation. Some stimulation, such as a radio or television, is helpful, but excessive stimulation should be avoided.
Structure and routine help people with HIV-associated dementia stay oriented and give them a sense of security and stability. Any change in surroundings, routines, or caregivers should be explained to people clearly and simply.
Following a daily routine for tasks such as bathing, eating, and sleeping helps people with HIV-associated dementia remember. Following a regular routine at bedtime may help them sleep better.
Activities scheduled on a regular basis can help people feel independent and needed by focusing their attention on pleasurable or useful tasks. Such activities should include physical and mental activities. Activities should be broken down in small parts or simplified as the dementia worsens.
Care for caregivers
Caring for people with dementia is stressful and demanding, and caregivers may become depressed and exhausted, often neglecting their own mental and physical health. The following measures can help caregivers (see table Caring for Caregivers Caring for Caregivers ):
Learning about how to effectively meet the needs of people with dementia and what to expect from them: Caregivers can get this information from nurses, social workers, organizations, and published and online materials.
Seeking help when it is needed: Caregivers can talk to social workers (including those in the local community hospital) about appropriate sources of help, such as day-care programs, visits by home nurses, part-time or full-time housekeeping assistance, and live-in assistance. Counseling and support groups can also help.
Caring for self: Caregivers need to remember to take care of themselves. They should not given up their friends, hobbies, and activities.
Before people with HIV-associated dementia become too incapacitated, decisions should be made about medical care, and financial and legal arrangements should be made. These arrangements are called advance directives Advance Directives Health care advance directives are legal documents that communicate a person’s wishes about health care decisions in the event the person becomes incapable of making health care decisions. There... read more . People should appoint a person who is legally authorized to make treatment decisions on their behalf (a health care proxy). They should discuss their health care wishes Treatment Options at the End of Life Often, the available choices for end-of-life care involve a decision whether to accept the likelihood of dying sooner but to be more comfortable or attempt to live slightly longer by receiving... read more with this person and their doctor. Such issues are best discussed with all concerned long before decisions are necessary.
As HIV-associated dementia worsens, treatment tends to be directed at maintaining the person’s comfort rather than at attempting to prolong life.
The following English-language resources may be useful. Please note that THE MANUAL is not responsible for the content of these resources.
Dementia.org: General information about the causes, symptoms, treatments, and stages of dementia.
Health Direct: Dementia Video Series: General information about dementia, recommendations about the warning signs of dementia, treatment and research, and caring for a person with dementia. Also provides links to articles on similar topics.
National Institute of Neurological Disorders and Stroke's Dementia Information Page: Information about treatments and prognosis for people with dementia and links to clinical trials.