Merck Manual

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Conditions That Occur With Certain Multiple Endocrine Neoplasia Syndromes

Conditions That Occur With Certain Multiple Endocrine Neoplasia Syndromes

Condition

MEN 1

MEN 2A

MEN 2B

MEN 4

95% or more

10–20%

55–80%

30–90%

15–25%

Pituitary gland tumors

15–42%

30–45%

More than 95%

More than 95%

40–50%

50%

Neuromas (growths around nerves) on mucous membranes

Almost 100%

Almost 100%

10–15%

5%

Lipomas*

Up to 35%

Angioma or collagenomas† (especially on the face)

70–85%

* A lipoma is a growth of fatty tissue that is usually benign.

† An angioma is a growth of small blood vessels that is usually benign. A collagenoma is a benign growth of connective tissue in the skin.

MEN = multiple endocrine neoplasia.